Results 21 to 30 of about 121,748 (297)
Slovenian Veterinary Research, 2023 The pancreas is a complex gland that possesses both endocrine and exo-crine functions. The present study investigated the gross anatomy, histochemical fea-tures, and immunohistochemical expression of insulin, glucagon, somatostatin, and pancreatic ...
Ahmed Abdellatif
doaj +1 more source
Pancreatic islet transplantation [PDF]
Diabetology & Metabolic Syndrome, 2009 No formulation of exogenous insulin available to date has yet been able to mimic the physiological nictemeral rhythms of this hormone, and despite all engineering advancements, the theoretical proposal of developing a mechanical replacement for pancreatic beta cell still has not been reached.
Maria Lúcia Corrêa-Giannella +1 more
openaire +4 more sources
Comparison of Cooling Systems during Islet Purification
Cell Transplantation, 2006 Islet isolation is a complex procedure that includes digestion and purification of pancreatic tissue. As we move towards clinical regulatory control and standardization, understanding of the detailed stages of the procedure have become increasingly ...
Sue Swift +4 more
doaj +1 more source
Pharmaceutics, 2021 Glucagon-like peptide-1 receptor (GLP-1R) agonists are being used for the treatment of type 2 diabetes (T2D) and may have beneficial effects on the pancreatic β-cells.
Gianmarco Ferri +10 more
doaj +1 more source
Frontiers in Endocrinology, 2023 Mitochondria are the powerhouse of the cell and dynamically control fundamental biological processes including cell reprogramming, pluripotency, and lineage specification.
Ila Tewari Jasra +6 more
doaj +1 more source
Donor Islet Endothelial Cells in Pancreatic Islet Revascularization [PDF]
Diabetes, 2011 OBJECTIVE Freshly isolated pancreatic islets contain, in contrast to cultured islets, intraislet endothelial cells (ECs), which can contribute to the formation of functional blood vessels after transplantation. We have characterized how donor islet endothelial cells (DIECs) may contribute to the revascularization ...
Alejandro Caicedo +19 more
openaire +3 more sources
Detection of Microbial Contamination during Human Islet Isolation
Cell Transplantation, 2007 Current good manufacturing practice (cGMP) islet processing facilities provide an ultraclean environment for the safe production of clinical grade islets for transplantation into immunosuppressed diabetic recipients.
Tatsuya Kin +3 more
doaj +1 more source
Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts [PDF]
Proceedings of the National Academy of Sciences, 2010 Islet transplantation is a promising treatment for diabetes but long-term success is limited by progressive graft loss. Aggregates of the beta cell peptide islet amyloid polypeptide (IAPP) promote beta cell apoptosis and rapid amyloid formation occurs in transplanted islets.
Gregory S. Korbutt +15 more
openaire +3 more sources
Estimation of Pancreas Weight from Donor Variables
Cell Transplantation, 2006 Previous studies have identified several donor factors affecting the outcome of islet isolation. Pancreas weight has not been considered as a donor selection criterion, because a value cannot be obtained prior to organ procurement.
Tatsuya Kin +3 more
doaj +1 more source
Stem Cell Reports, 2017 Beta-cell replacement therapy is an effective means to restore glucose homeostasis in select humans with autoimmune diabetes. The scarcity of “healthy” human donor pancreata restricts the broader application of this effective curative therapy.
Andrew R. Pepper +10 more
doaj +1 more source