Results 31 to 40 of about 126,560 (317)

Comparison of Cooling Systems during Islet Purification

Cell Transplantation, 2006
Islet isolation is a complex procedure that includes digestion and purification of pancreatic tissue. As we move towards clinical regulatory control and standardization, understanding of the detailed stages of the procedure have become increasingly ...
Sue Swift, Tatsuya Kin, Mohammadreza Mirbolooki, Richard Wilson, Jonathan R. T. Lakey Ph.D.   +4 more
doaj   +1 more source

Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

eLife, 2023
Pancreatic islets are three-dimensional cell aggregates consisting of unique cellular composition, cell-to-cell contacts, and interactions with blood vessels.
Wilma Tixi, Maricela Maldonado, Ya-Ting Chang, Amy Chiu, Wilson Yeung, Nazia Parveen, Michael S Nelson, Ryan Hart, Shihao Wang, Wu Jih Hsu, Patrick Fueger, Janel L Kopp, Mark O Huising, Sangeeta Dhawan, Hung Ping Shih   +14 more
doaj   +1 more source

EXPRESSION OF INSULIN, GLUCAGON, SOMATOSTATIN, AND PANCREATIC POLYPEPTIDE IN THE PANCREAS OF THE EURASIAN MOORHEN (Gallinula chloropus)

Slovenian Veterinary Research, 2023
The pancreas is a complex gland that possesses both endocrine and exo-crine functions. The present study investigated the gross anatomy, histochemical fea-tures, and immunohistochemical expression of insulin, glucagon, somatostatin, and pancreatic ...
Ahmed Abdellatif
doaj   +1 more source

Islet cell transplantation [PDF]

Postgraduate Medical Journal, 2007
Abstract People with type 1 diabetes have normal exocrine pancreatic function, making islet cell rather than whole organ transplantation an attractive option. Achieving insulin independence in type 1 diabetes was the perceived goal of islet cell transplantation.
Srinivasan, P, Huang, G C, Amiel, S A, Heaton, N D   +3 more
openaire   +3 more sources

Detection of Microbial Contamination during Human Islet Isolation

Cell Transplantation, 2007
Current good manufacturing practice (cGMP) islet processing facilities provide an ultraclean environment for the safe production of clinical grade islets for transplantation into immunosuppressed diabetic recipients.
Tatsuya Kin, Shawn Rosichuk, A. M. James Shapiro, Jonathan R. T. Lakey Ph.D.   +3 more
doaj   +1 more source

Evaluating Islet Cell Isolation and Transplantation From Donors Following Medical Assistance in Dying

Transplantation Direct
Background. Limited information is available regarding outcomes of islet cell isolation (ICI) and transplantation (ITx) using medical assistance in dying (MAiD) donors.
Alessandro Parente, MD, PhD, Kevin Verhoeff, MD, PhD, Tatsuya Kin, MD, PhD, Joshua Hefler, MD, PhD, Braulio A. Marfil-Garza, MD, PhD, Norberto Sanchez-Fernandez, MD, Anna Lam, MD, MSc, James Lyon, MD, PhD, Doug O’Gorman, BSc, Khaled Z. Dajani, MD, Blaire L. Anderson, MD, David L. Bigam, MD, MSc, Patrick E. MacDonald, MD, PhD, A. M. James Shapiro, MD, PhD, FRCS (Eng), FRCSC, MSM   +13 more
doaj   +1 more source

Estimation of Pancreas Weight from Donor Variables

Cell Transplantation, 2006
Previous studies have identified several donor factors affecting the outcome of islet isolation. Pancreas weight has not been considered as a donor selection criterion, because a value cannot be obtained prior to organ procurement.
Tatsuya Kin, Travis B. Murdoch, A. M. James Shapiro, Jonathan R. T. Lakey Ph.D.   +3 more
doaj   +1 more source

Spatiotemporal Correlation Spectroscopy Reveals a Protective Effect of Peptide-Based GLP-1 Receptor Agonism against Lipotoxicity on Insulin Granule Dynamics in Primary Human β-Cells

Pharmaceutics, 2021
Glucagon-like peptide-1 receptor (GLP-1R) agonists are being used for the treatment of type 2 diabetes (T2D) and may have beneficial effects on the pancreatic β-cells.
Gianmarco Ferri, Marta Tesi, Luca Pesce, Marco Bugliani, Francesca Grano, Margherita Occhipinti, Mara Suleiman, Carmela De Luca, Lorella Marselli, Piero Marchetti, Francesco Cardarelli   +10 more
doaj   +1 more source

Effect of Manufacturing Procedures on Human Islet Isolation from Donor Pancreata Standardized by the North American Islet Donor Score

Cell Transplantation, 2017
This study investigates manufacturing procedures that affect islet isolation outcomes from donor pancreata standardized by the North American Islet Donor Score (NAIDS).
Chun-Chieh Yeh, Ling-Jia Wang, James J. Mcgarrigle, Yong Wang, Chien-Chang Liao, Mustafa Omami, Arshad Khan, Mohammad Nourmohammadzadeh, Joshua Mendoza-Elias, Benjamin Mccracken, Enza Marchese, Barbara Barbaro, Jose Oberholzer   +12 more
doaj   +1 more source

Inducible Mosaic Cell Labeling Provides Insights Into Pancreatic Islet Morphogenesis

Frontiers in Cell and Developmental Biology, 2020
Pancreatic islets, discrete microorgans embedded within the exocrine pancreas, contain beta cells which are critical for glucose homeostasis. Loss or dysfunction of beta cells leads to diabetes, a disease with expanding global prevalence, and for which ...
Julia Freudenblum, Dirk Meyer, Robin A. Kimmel   +2 more
doaj   +1 more source