Results 31 to 40 of about 121,748 (297)

Islet Encapsulation: Strategies to Enhance Islet Cell Functions [PDF]

Tissue Engineering, 2007
Diabetes is one of the most prevalent, costly, and debilitating diseases in the world. Although traditional insulin therapy has alleviated the short-term effects, long-term complications are ubiquitous and harmful. For these reasons, alternative treatment options are being developed.
Brent Vernon, Ryan Angus, Jonathan Beck, David W. Britt, Kytai T. Nguyen, Kytai T. Nguyen, Ben Madsen   +6 more
openaire   +4 more sources

Extreme caution on the use of sirolimus for the congenital hyperinsulinism in infancy patient

Orphanet Journal of Rare Diseases, 2017
We have recently published on the limited effectiveness of sirolimus as a treatment option for hypoglycaemia as a consequence of hyperinsulinism. Our data oppose the view that mTOR inhibitors provide new opportunities for the treatment of patients with ...
Indraneel Banerjee, Diva De Leon, Mark J. Dunne   +2 more
doaj   +1 more source

Islets and Glucose Homeostasis [PDF]

International Journal of Endocrinology, 2015
Diabetes mellitus is a chronic progressive metabolic disease, resulting from both insulin resistance and the dysfunction of beta-cells. Beta-cell apoptosis is a crucial pathophysiology leading to diabetes [1]. Aberrant immune system leads to destroying of beta-cells occurring in type 1 diabetes. Infiltration of immune cells around beta-cells and attack
Tien-Jyun Chang, Gang Xu, Jyuhn-Huarng Juang   +2 more
openaire   +4 more sources

Effect of Manufacturing Procedures on Human Islet Isolation from Donor Pancreata Standardized by the North American Islet Donor Score

Cell Transplantation, 2017
This study investigates manufacturing procedures that affect islet isolation outcomes from donor pancreata standardized by the North American Islet Donor Score (NAIDS).
Chun-Chieh Yeh, Ling-Jia Wang, James J. Mcgarrigle, Yong Wang, Chien-Chang Liao, Mustafa Omami, Arshad Khan, Mohammad Nourmohammadzadeh, Joshua Mendoza-Elias, Benjamin Mccracken, Enza Marchese, Barbara Barbaro, Jose Oberholzer   +12 more
doaj   +1 more source

Evaluating Islet Cell Isolation and Transplantation From Donors Following Medical Assistance in Dying

Transplantation Direct
Background. Limited information is available regarding outcomes of islet cell isolation (ICI) and transplantation (ITx) using medical assistance in dying (MAiD) donors.
Alessandro Parente, MD, PhD, Kevin Verhoeff, MD, PhD, Tatsuya Kin, MD, PhD, Joshua Hefler, MD, PhD, Braulio A. Marfil-Garza, MD, PhD, Norberto Sanchez-Fernandez, MD, Anna Lam, MD, MSc, James Lyon, MD, PhD, Doug O’Gorman, BSc, Khaled Z. Dajani, MD, Blaire L. Anderson, MD, David L. Bigam, MD, MSc, Patrick E. MacDonald, MD, PhD, A. M. James Shapiro, MD, PhD, FRCS (Eng), FRCSC, MSM   +13 more
doaj   +1 more source

Human Amniotic Epithelial Cells Induce Localized Cell-Mediated Immune Privilege in Vitro: Implications for Pancreatic Islet Transplantation

Cell Transplantation, 2011
Chronic systemic immunosuppression in cell replacement therapy restricts its clinical application. This study sought to explore the potential of cell-based immune modulation as an alternative to immunosuppressive drug therapy in the context of pancreatic
Khalid M. Qureshi, Robert J. Oliver, Michelle B. Paget, Hilary E. Murray, Clifford J. Bailey, Richard Downing   +5 more
doaj   +1 more source

The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors

Scientific Reports, 2022
The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia.
Daniel Brandhorst, Heide Brandhorst, Samuel Acreman, Paul R. V. Johnson   +3 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Knowledge gaps in rodent pancreas biology: taking human pluripotent stem cell-derived pancreatic beta cells into our own hands

Frontiers in Endocrinology, 2016
In the field of stem cell biology and diabetes, we and others seek to derive mature and functional human pancreatic β cells for disease modeling and cell replacement therapy.
Munirah Mohamad Santosa, Blaise Su Jun Low, Nicole Min Qian Pek, Adrian Kee Keong Teo   +3 more
doaj   +1 more source

In silico identification and verification of ferroptosis-related genes in type 2 diabetic islets

Frontiers in Endocrinology, 2022
Type 2 diabetes (T2D) is a major global public health burden, with β-cell dysfunction a key component in its pathogenesis. However, the exact pathogenesis of β-cell dysfunction in T2D is yet to be fully elucidated.
Meiqi Yin, Liang Zhou, Yanan Ji, Rongxin Lu, Wei Ji, Guorong Jiang, Jin Ma, Jin Ma, Xiudao Song   +8 more
doaj   +1 more source