Results 31 to 40 of about 235,553 (209)
, 2018 Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the ...
DiMeglio, Linda A. +2 more
core +1 more source
Pharmaceutics, 2021 Glucagon-like peptide-1 receptor (GLP-1R) agonists are being used for the treatment of type 2 diabetes (T2D) and may have beneficial effects on the pancreatic β-cells.
Gianmarco Ferri +10 more
doaj +1 more source
Cell Transplantation, 2017 This study investigates manufacturing procedures that affect islet isolation outcomes from donor pancreata standardized by the North American Islet Donor Score (NAIDS).
Chun-Chieh Yeh +12 more
doaj +1 more source
Scientific Reports, 2022 The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia.
Daniel Brandhorst +3 more
doaj +1 more source
Cell Transplantation, 2011 Chronic systemic immunosuppression in cell replacement therapy restricts its clinical application. This study sought to explore the potential of cell-based immune modulation as an alternative to immunosuppressive drug therapy in the context of pancreatic
Khalid M. Qureshi +5 more
doaj +1 more source
Inducible Mosaic Cell Labeling Provides Insights Into Pancreatic Islet Morphogenesis
Frontiers in Cell and Developmental Biology, 2020 Pancreatic islets, discrete microorgans embedded within the exocrine pancreas, contain beta cells which are critical for glucose homeostasis. Loss or dysfunction of beta cells leads to diabetes, a disease with expanding global prevalence, and for which ...
Julia Freudenblum +2 more
doaj +1 more source
Indefinite survival of rat islet allografts following infusion of donor bone marrow without cytoablation [PDF]
, 1996 We have tested the effect of donor bone marrow cell (DBMC) infusion on the survival of pancreatic islet allografts in the rat, without the use of cytoablative recipient conditioning. Lewis and diabetic Brown Norway rats were used as donors and recipients,
C Ricordi +8 more
core +1 more source
Extreme caution on the use of sirolimus for the congenital hyperinsulinism in infancy patient
Orphanet Journal of Rare Diseases, 2017 We have recently published on the limited effectiveness of sirolimus as a treatment option for hypoglycaemia as a consequence of hyperinsulinism. Our data oppose the view that mTOR inhibitors provide new opportunities for the treatment of patients with ...
Indraneel Banerjee +2 more
doaj +1 more source
Islet Transplantation in the UK [PDF]
CellR4, 2019 This commentary outlines the development and current status of the UK Islet Transplant Programme in the UK. The author makes the case that it is now time for similar fully funded beta-cell programmes to be made available in many other countries as well.
P. Johnson +1 more
doaj +1 more source
Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity [PDF]
, 2015 The nuclear factor κB (NF-κB) pathway is a master regulator of inflammatory processes and is implicated in insulin resistance and pancreatic β cell dysfunction in the metabolic syndrome.
Brink, Robert +12 more
core +4 more sources