Results 151 to 160 of about 344,376 (339)
Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase
Cell Discovery, 2020 Human NAD-dependent isocitrate dehydrogenase or HsIDH3 catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the TCA cycle. HsIDH3 exists and functions as a heterooctamer composed of the αβ and αγ heterodimers, and is regulated ...
Pengkai Sun +3 more
doaj +1 more source
Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer
Clinical Cancer Research, 2016 IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to α-ketoglutarate (α-KG) and concomitantly produce reduced NADPH from NADP+.
O. Clark, K. Yen, I. Mellinghoff
semanticscholar +1 more source
Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. [PDF]
, 2018 Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumorigenesis in several cancers. Although significant research has focused on the hypermethylation phenotypes associated with (D)2-hydroxyglutarate (D2HG ...
Badur, Mehmet G +8 more
core
Radiology, 2017 Purpose To explore the diffusion-tensor (DT) imaging-defined invasive phenotypes of both isocitrate dehydrogenase (IDH-1)-mutated and IDH-1 wild-type glioblastomas. Materials and Methods Seventy patients with glioblastoma were prospectively recruited and
S. Price +6 more
semanticscholar +1 more source
ISOCITRIC DEHYDROGENASE IN GREEN LEAVES [PDF]
New Phytologist, 1951 A considerable amount of work has been done on the identification and isolation of enzyme systems in plants responsible for biological oxidations. Various metal oxidases have been identified, such as polyphenol oxidase in leaves and other tissues (Nelson & Dawson, I 944), ascorbic acid oxidase in many tissues (Tauber, Kleiner & Mischkind, I935; Stone ...
openaire +2 more sources
Free Energy of Activation for the Comorosan Effect [PDF]
arXiv, 2007 Initial reaction rate data for lactic dehydrogenase / pyruvate, lactic dehydrogenase / lactate and malic dehydrogenase / malate enzyme reactions were analyzed to obtain activation free energy changes of -329, -195 and -221 cal/mole, respectively, for rate increases associated with time-specific irradiation of the crystalline substrates prior to ...
arxiv
Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
Cell Reports Medicine, 2021 Ingvild Hvinden +3 more
semanticscholar +1 more source
Journal of the American Society of Nephrology, 2017 Mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate, synthesizing NADPH, which is essential for mitochondrial redox balance.
S. Han +7 more
semanticscholar +1 more source
Adjunctive perampanel for glioma-associated epilepsy
Epilepsy and Behavior Case Reports, 2018 Glioma-associated epilepsy is associated with excessive glutamate signaling. We hypothesized that perampanel, an amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor antagonist, would treat glioma-related epilepsy.
Anastasie M. Dunn-Pirio +9 more
doaj
Evolution: The Case of the Glyceraldehyde-3-Phosphate Dehydrogenase Gene [PDF]
arXiv, 2000 The enzyme Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) catalyses the decomposition of glucose. The gene that produces the GAPDH is therefore present in a wide class of organisms. We show that for this gene the average value of the fluctuations in nucleotide distribution in the codons, normalized to strand bias, provides a reasonable measure of how
arxiv