Results 1 to 10 of about 34,359 (255)
Synthesis and structure of a tetrahedral homoleptic CuI complex with xylyl isocyanide [PDF]
Acta Crystallographica Section E: Crystallographic CommunicationsTreatment of the CuI precursor [Cu(NCMe)4]PF6 with excess (10 equivalents) of relatively bulky xylyl isocyanide formed a tetra(isocyanide) complex, namely, tetrakis(2,6-dimethylphenylisocyanide)copper(I) hexafluorophosphate, [Cu(C9H9N)4]PF6 or [Cu(CNXyl ...
A. M. Buddhika Chandima +2 more
doaj +2 more sources
Divergent isoindolinone synthesis through palladium-catalyzed isocyanide bridging C–H activation
Cell Reports Physical Science, 2022 Summary: The formation of thermodynamically accessible metallacycle is crucial to achieve site-selective C–H bond activation. Here, we report an isocyanide-bridging C–H activation through the formation of a five-membered palladacycle. As such, a proximal
Fulin Zhang +6 more
doaj +2 more sources
Green Chemistry, 2020 Isocyanides are important chemicals, with limited availability, thus reducing their general use. Our highly improved isocyanide synthesis performed on mole to μ-mole scale, individually or in a 96-well parallel fashion enables unprecedented exploration ...
P. Patil +2 more
semanticscholar +4 more sources
A trustworthy mechanochemical route to isocyanides [PDF]
Beilstein Journal of Organic Chemistry, 2022 Isocyanides are hardly produced, dramatically sensitive to purification processes, and complex to handle as synthetic tools. Notwithstanding, they represent one of the most refined and valuable compounds for accessing sophisticated and elegant synthetic ...
Francesco Basoccu +5 more
doaj +2 more sources
Synthesis of (macro)heterocycles by consecutive/repetitive isocyanide-based multicomponent reactions
Beilstein Journal of Organic Chemistry, 2019 Isocyanide-based multicomponent reactions are a versatile tool in the synthesis of heterocycles. This review describes recently developed approaches based on the combination of consecutive or repetitive isocyanide-based multicomponent reactions for the ...
Angélica de Fátima S. Barreto +1 more
doaj +2 more sources
Nature Communications, 2023 Abstract The S N 2 nucleophilic substitution reaction is a vital organic transformation used for drug and natural product synthesis. Nucleophiles like cyanide, oxygen, nitrogen, sulfur, or phosphorous replace halogens or sulfonyl esters, forming new bonds.
Patil, Pravin +3 more
openaire +5 more sources
Base Metal-Catalyzed Isocyanide Insertions. [PDF]
Angewandte Chemie, 2019 Isocyanides are diverse C1 building blocks given their potential to react with nucleophiles, electrophiles and radicals. Therefore, perhaps not surprisingly, isocyanides are highly valuable as inputs for multicomponent reactions (MCRs) and other one-pot ...
Jurriën W Collet +4 more
semanticscholar +4 more sources
Multiple Isocyanide insertions promoted by protic and Lewis acids [PDF]
Tetrahedron Chem, 2023 The protonation, or Lewis Acid complexation, of electrophiles can trigger the sequential insertion of two or more isocyanides resulting in valuable iminonitriles or heterocycles.
John Kornfeind, Fraser F. Fleming
doaj +2 more sources
[3+2] Cycloaddition of Tosylmethyl Isocyanide with Styrylisoxazoles: Facile Access to Polysubstituted 3-(Isoxazol-5-yl)pyrroles [PDF]
Molecules, 2017 A facile access to polysubstituted 3-(isoxazol-5-yl)pyrroles was developed through [3+2] cycloaddition of tosylmethyl isocyanide (TosMIC) and styrylisoxazoles.
Xueming Zhang, Xianxiu Xu, Dawei Zhang
doaj +2 more sources
Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in
mBio, 2018 Microbial secondary metabolites, including isocyanide moieties, have been extensively mined for their repertoire of bioactive properties. Although the first naturally occurring isocyanide (xanthocillin) was isolated from the fungus Penicillium notatum ...
Fang Yun Lim +7 more
doaj +2 more sources