Results 1 to 10 of about 23,536 (214)
Catalytic asymmetric reactions of isocyanides for constructing non-central chirality [PDF]
Beilstein Journal of Organic ChemistryBeyond the conventional carbon-centered chirality, catalytic asymmetric transformations of isocyanides have recently emerged as a powerful strategy for the efficient synthesis of structurally diverse scaffolds featuring axial, planar, helical, and ...
Jia-Yu Liao
doaj +2 more sources
A trustworthy mechanochemical route to isocyanides
Beilstein Journal of Organic Chemistry, 2022 Isocyanides are hardly produced, dramatically sensitive to purification processes, and complex to handle as synthetic tools. Notwithstanding, they represent one of the most refined and valuable compounds for accessing sophisticated and elegant synthetic ...
Francesco Basoccu +5 more
doaj +4 more sources
Medicinal Chemistry of Isocyanides [PDF]
Chemical Reviews, 2021 In eons of evolution, isocyanides carved out a niche in the ecological systems probably thanks to their metal coordinating properties. In 1859 the first isocyanide was synthesized by humans and in 1950 the first natural isocyanide was discovered. Now, at the beginning of XXI century, hundreds of isocyanides have been isolated both in prokaryotes and ...
Alberto Massarotti +4 more
openaire +5 more sources
Synthesis of spiroindolenines through a one-pot multistep process mediated by visible light [PDF]
Beilstein Journal of Organic ChemistrySpiro-heterocyclic indolenines are privileged scaffolds widely present in numerous indole alkaloids. Here, we develop a novel approach for the one-pot multistep synthesis of different spiro[indole-isoquinolines].
Francesco Gambuti +4 more
doaj +2 more sources
Efficacy of radical reactions of isocyanides with heteroatom radicals in organic synthesis [PDF]
Beilstein Journal of Organic ChemistryIsocyanide is a promising synthetic reagent not only as a one-carbon homologation reagent but also as a nitrogen source for nitrogen-containing molecules.
Akiya Ogawa, Yuki Yamamoto
doaj +2 more sources
Urea Synthesis from Isocyanides and O-Benzoyl Hydroxylamines Catalyzed by a Copper Salt
Molecules, 2022 In the presence of CuOAc, a series of unsymmetric ureas can be generated in moderate to good yields under mild reaction conditions (10 mol% of CuOAc, 2 equiv t-BuONa or PhONa, 30 °C), using aryl isocyanides and O-benzoyl hydroxylamines as the readily ...
Ning Yu +5 more
doaj +1 more source
Antibiotics, 2023 Multicomponent reactions (MCR) have been used to synthesize a wide range of analogs from several classes of heterocyclic compounds, with multifaceted medicinal uses. The synthesis of highly functionalized molecules in a single pot is a unique property of
Sameer Quazi +3 more
doaj +1 more source
Nature Communications, 2023 AbstractThe SN2 nucleophilic substitution reaction is a vital organic transformation used for drug and natural product synthesis. Nucleophiles like cyanide, oxygen, nitrogen, sulfur, or phosphorous replace halogens or sulfonyl esters, forming new bonds.
Patil, Pravin +3 more
openaire +4 more sources
Ugi Four-Component Reactions Using Alternative Reactants
Molecules, 2023 The Ugi four-component reaction (Ugi-4CR) undoubtedly is the most prominent multicomponent reaction (MCRs) that has sparked organic chemists’ interest in the field.
Seyyed Emad Hooshmand, Wei Zhang
doaj +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2022 The reaction of the [K(18-crown-6)(thf)2]1+ (thf is tetrahydrofuran) salt of bis(anthracene)ferrate(−1), or [Fe(C14H10)2]−, with 2,6-dimethylphenyl isocyanide (CNXyl) in thf resulted in the formation of two new iron isocyanide complexes, namely, [(1,2,3 ...
William W. Brennessel, John E. Ellis
doaj +1 more source