Results 11 to 20 of about 34,359 (255)

Turn-Induction in Peptides Incorporating Novel Cyrene-Derived α,α-Disubstituted Amino Acid. [PDF]

J Pept Sci
Novel chiral cyrene‐derived Cyr residues were incorporated into peptides. The α,α‐disubstituted amino acid residue was introduced using the Ugi reaction. X‐ray crystallographic analysis of R‐ and S‐Cyr residues indicated preference to adopt left‐ and right‐handed α‐helical conformations, respectively.
Bhowal KB, Hitti R, Lubell WD.
europepmc   +2 more sources

Single-Molecule Vibrational Characterization of Binding Geometry Effects on Isocyanide-Metal Interactions. [PDF]

Nano Lett
Bi L, Wang Z, Balto KP, Tao AR, Pascal TA, Zhang Y, Figueroa JS, Li S.   +7 more
europepmc   +2 more sources

A rare isocyanide derived from an unprecedented neutral yttrium(ii) bis(amide) complex

Chemical Science, 2023
A room temperature stable complex formulated as Y(NHAr*)2 has been prepared, where Ar* = 2,6-(2,4,6-(iPr)3C6H2)C6H3, by KC8 reduction of ClY(NHAr*)2. Based on EPR evidence, Y(NHAr*)2 is an example of a d1 Y(ii) complex with significant delocalization of ...
Rashmi Jena, Florian Benner, Francis Delano, D. Holmes, J. McCracken, Selvan Demir, A. Odom   +6 more
semanticscholar   +1 more source

Urea Synthesis from Isocyanides and O-Benzoyl Hydroxylamines Catalyzed by a Copper Salt

Molecules, 2022
In the presence of CuOAc, a series of unsymmetric ureas can be generated in moderate to good yields under mild reaction conditions (10 mol% of CuOAc, 2 equiv t-BuONa or PhONa, 30 °C), using aryl isocyanides and O-benzoyl hydroxylamines as the readily ...
Ning Yu, Jing-Fang Lv, Shi-Mei He, Yanyan Cui, Ye Wei, Kun Jiang   +5 more
doaj   +1 more source

Crystal structures of two novel iron isocyanides from the reaction of 2,6-dimethylphenyl isocyanide, CNXyl, with bis(anthracene)ferrate(−1)

Acta Crystallographica Section E: Crystallographic Communications, 2022
The reaction of the [K(18-crown-6)(thf)2]1+ (thf is tetrahydrofuran) salt of bis(anthracene)ferrate(−1), or [Fe(C14H10)2]−, with 2,6-dimethylphenyl isocyanide (CNXyl) in thf resulted in the formation of two new iron isocyanide complexes, namely, [(1,2,3 ...
William W. Brennessel, John E. Ellis
doaj   +1 more source

RETRACTED: The Discovery of Novel Antimicrobial Agents Through the Application of Isocyanide-Based Multicomponent Reactions

Antibiotics, 2023
Multicomponent reactions (MCR) have been used to synthesize a wide range of analogs from several classes of heterocyclic compounds, with multifaceted medicinal uses. The synthesis of highly functionalized molecules in a single pot is a unique property of
Sameer Quazi, Maliha Tabassum Rashid, Javid Ahmad Malik, Shreelaxmi Gavas   +3 more
doaj   +1 more source

Copper starvation induces antimicrobial isocyanide integrated into two distinct biosynthetic pathways in fungi

Nature Communications, 2022
The genomes of many filamentous fungi, such as Aspergillus spp., include diverse biosynthetic gene clusters of unknown function. We previously showed that low copper levels upregulate a gene cluster that includes crmA, encoding a putative isocyanide ...
Tae Hyung Won, J. Bok, Nischala Nadig, Nandhitha Venkatesh, Grant R Nickles, C. Greco, Fang Yun Lim, Jennifer B González, B. Turgeon, N. Keller, Frank C. Schroeder   +10 more
semanticscholar   +1 more source

Efficient Isocyanide-less Isocyanide-Based Multicomponent Reactions [PDF]

Organic Letters, 2015
Isocyanides are the "Jekyll and Hyde" of organic chemistry allowing for extremely interesting transformations that are not only extremely odorous but also noxious. Therefore, an isocyanide-less isocyanide-based multicomponent reaction (IMCR) has been developed, and this protocol is expected to replace many of the old procedures in the future not only ...
Neochoritis, Constantinos G.; Stotani, Silvia; Mishra, Bhupendra; Domling, Alexander   +4 more
openaire   +3 more sources

Ugi Four-Component Reactions Using Alternative Reactants

Molecules, 2023
The Ugi four-component reaction (Ugi-4CR) undoubtedly is the most prominent multicomponent reaction (MCRs) that has sparked organic chemists’ interest in the field.
Seyyed Emad Hooshmand, Wei Zhang
doaj   +1 more source

Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N≡C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis.

ACS Catalysis, 2022
Despite the diversity of reactions catalyzed by 2-oxoglutarate-dependent nonheme iron (Fe/2OG) enzymes identified in recent years, only a limited number of these enzymes have been investigated in mechanistic detail.
Tzu‐Yu Chen, Ziyang Zheng, Xuan Zhang, Jinfeng Chen, Lide Cha, Yijie Tang, Yisong Guo, Jiahai Zhou, Binju Wang, Hung‐wen Liu, Wei‐chen Chang   +10 more
semanticscholar   +1 more source