Results 51 to 60 of about 23,536 (214)

Silver-Catalyzed Decarboxylative Acylation of Isocyanides Accesses to α-Ketoamides with Air as a Sole Oxidant

Molecules, 2023
α-Ketoamide moieties, as privileged units, may represent a valuable option to develop compounds with favorable biological activities, such as low toxicity, promising PK and drug-like properties.
Jia Xu, Xue Li, Xing-Yu Chen, Yu-Ting He, Jie Lei, Zhong-Zhu Chen, Zhi-Gang Xu   +6 more
doaj   +1 more source

1,5‐Diisocyanonaphthalene: The Lowest Molecular Weight Fluorescent Probe for the Determination of Trace Amounts of Sulfoxides in Both Organic and Aqueous Media

ChemPhotoChem, EarlyView.
We present 1,5‐DIN as a low‐cost, efficient fluorescent probe for trace DMSO detection in organic and aqueous media. It shows strong quenching, with LODs from 5–50 ppm, even in complex matrices. Theoretical insights support its mechanism, highlighting its promise for practical applications.
Attila Kovács, Rajmond Schiwert, Péter Kun, Zoltán Mucsi, László Vanyorek, Béla Viskolcz, Miklós Nagy   +6 more
wiley   +1 more source

Amidine Syntheses from Classic to Contemporary for Medicinal Lead Compounds and Natural Products

European Journal of Organic Chemistry, EarlyView.
A revolution is underway in the synthesis of amidines with new methods unlocking complex, highly substituted amidines or closely related derivatives such as N‐sulfonyl amidines. This review surveys recent advances in amidines and related compounds, including methods to install them and bioactive molecules prominently featuring the amidine functionality.
Wyatt R. Swift‐Ramirez, Gregory A. Weiss   +1 more
wiley   +1 more source

One‐Pot Synthesis of Novel β‐Carboline‐{α‐Acylaminoamide}‐Bisindole Derivatives: Antibacterial Evaluation, Molecular Docking, and Density Functional Theory Studies

ChemistryOpen, EarlyView.
A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) employing an atom‐economical one‐pot Ugi four‐component reaction and their antibacterial testing alongside docking studies, is reported. A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) is designed and synthesized employing an atom‐economical one‐pot Ugi ...
Ankit Kumar Atri, Lavanya Khullar, Gobind Kumar, Sahil Mishra, Tamanna Dua, Vinay Singh, Kusum Harjai, Parvesh Singh, Vasundhara Singh   +8 more
wiley   +1 more source

In Situ and Operando Analytical Techniques of Single‐Atom Catalysts for Electrocatalytic CO2 Reduction

Small Methods, EarlyView.
Single‐atom catalysts (SACs) exhibit significant potential in CO2 reduction reactions (CO2RR) due to their unique geometric and electronic configurations. In situ and operando analytical techniques are essential for understanding CO2RR mechanisms and designing effective catalysts.
Rongbo Sun, Xingyun Liu, Jingyao Huang, Yuchao Wang, Hongwen Huang, Yongpeng Lei, Jingjie Ge   +6 more
wiley   +1 more source

Chemistry, Applications, and Synthesis Methods of Indole Derivatives: A Comprehensive Review

The Chemical Record, EarlyView.
Indole and its derivatives represent a vital class of heterocycles with broad applications in pharmaceuticals, agrochemicals, and materials science. This review explores their applications, biosynthesis, key derivatives such as tryptophan, and presents an overview of both classical and modern synthetic methodologies, with a focus on sustainable ...
Raphael Silva Moratório de Moraes, Ana Beatriz Mestre Botelho, Gabriel Tavares de Almeida Pinto, Searitha Couto Rodrigues, Maria Tereza Miranda Martins, Deivid Lucas Alves Soares, Camille Cardoso Cruz, Aline de Almeida Pinto, Flaviana Rodrigues Fintelman Dias, Patricia Dias Fernandes, Anna Claudia Cunha   +10 more
wiley   +1 more source

Reactions of Gallaphosphaketenes with Silylenes: Formation of Gallaphosphenes versus Silaphosphenes

European Journal of Inorganic Chemistry, Volume 28, Issue 29, October 16, 2025.
Gallaphosphaketene 1b reacts with silylenes either to silaphosphenes (2a/b, 4) or gallaphosphene 3. The nucleophilic character of the P atoms in 3 and 4 is proven in reactions with HCl, BnOH, MeI, MeOTf, and MeLi, respectively, demonstrating the promising potential of heavy π‐bonded p‐block element compounds for small molecule activation reactions ...
Pratima Dhawan, Oussama Tihouna, Christoph Wölper, Joost Möbius, Hannah Siera, Gebhard Haberhauer, Stephan Schulz   +6 more
wiley   +1 more source

Novel neutral iron(II) isocyanide maleonitrile dithiolate [Fe(S2C2(CN)2)(t-BuNC) 4] compound

Química Nova, 2004
FeBr2 reacts with the S2C2(CN)2(2-) ion (1:1 ratio) in the presence of an excess of t-BuNC in THF to give the mixed ligand [Fe(S2C2(CN)2)(t-BuNC) 4] compound.
Milton K. Morigaki, Elias M. da Silva, Carlos V. P. de Melo, Carlos Larica, Armando Biondo, Jair C. C. Freitas, Gilson H. M. Dias, Holgadinei R. Ribeiro   +7 more
doaj   +1 more source

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

Eco-Friendly Multi-Component Synthesis of γ-Spiroiminolactones in Water

Acta Chimica Slovenica, 2017
γ-Spiroiminolactone derivatives can be  synthesized by means of a one-pot three-component reaction between cyclic carbonyl compounds (isatin, acenaphthoquinone, ninhydrin), activated α-methylene groups and isocyanides in water using sodium dodecyl ...
Hamid Reza Safaei, Mohsen Shekouhy
doaj   +1 more source