Results 1 to 10 of about 475 (151)

Nanoformulation of a Trypanocidal Drug Isometamidium Chloride Ameliorates the Apurinic-Apyrimidinic DNA Sites/Genotoxic Effects in Horse Blood Cells [PDF]

Journal of Xenobiotics, 2023
Isometamidium chloride (ISM) is a trypanocide for the prophylactic and therapeutic use against vector-borne animal trypanosomosis (mainly Surra caused by Trypanosoma evansi) and African animal trypanosomosis caused by T. congolense/T. vivax/T.
Sandeep Singh, Balvinder Kumar, Neeraj Dilbaghi, Nisha Devi, Minakshi Prasad, Anju Manuja   +5 more
doaj   +2 more sources

The individual components of commercial isometamidium do not possess stronger trypanocidal activity than the mixture, nor bypass isometamidium resistance [PDF]

International Journal for Parasitology: Drugs and Drug Resistance, 2019
The four components present in the trypanocidal treatment Samorin, the commercially available formulation of isometamidium, were separated and purified by column chromatography.
Anthonius A. Eze, John Igoli, Alexander I. Gray, Graham G. Skellern, Harry P. De Koning   +4 more
doaj   +3 more sources

Vector competence of sterile male Glossina fuscipes fuscipes for Trypanosoma brucei brucei: implications for the implementation of the sterile insect technique in a sleeping sickness focus in Chad [PDF]

Parasites & Vectors, 2023
Background Human African trypanosomiasis (HAT) is a neglected tropical disease caused by Trypanosoma brucei gambiense transmitted by tsetse flies in sub-Saharan West Africa. In southern Chad the most active and persistent focus is the Mandoul focus, with
Mahamat Hissene Mahamat, Adeline Ségard, Jean-Baptiste Rayaisse, Rafael Argiles-Herrero, Andrew Gordon Parker, Philippe Solano, Adly Mohamed Mohamed Abd-Alla, Jérémy Bouyer, Sophie Ravel   +8 more
doaj   +2 more sources

Trypanocide usage in the cattle belt of southwestern Uganda [PDF]

Frontiers in Microbiology, 2023
BackgroundSystematic infrastructure and regulatory weaknesses over many decades, in communities struggling with animal African trypanosomiasis (AAT) would be expected to create an environment that would promote drug misuse and risk development of drug ...
Keneth Iceland Kasozi, Keneth Iceland Kasozi, Ewan Thomas MacLeod, Keith Robert Sones, Keith Robert Sones, Susan Christina Welburn, Susan Christina Welburn   +6 more
doaj   +2 more sources

Variation of sensitivity of Trypanosoma evansi isolates from Isiolo and Marsabit counties of Kenya to locally available trypanocidal drugs. [PDF]

PLoS ONE, 2023
Trypanocidal resistance is a major cause of treatment failure. This study evaluated the sensitivity of Trypanosoma evansi field isolates collected from Marsabit and Isiolo counties, Kenya. A total of 2,750 camels were screened using parasitological tests
Raymond E Mdachi, Kennedy O Ogolla, Joanna E Auma, Florence N Wamwiri, Richard K Kurgat, Kennedy B Wanjala, Lawrence G Mugunieri, Phylis M Alusi, Judith K Chemuliti, Phoebe W Mukiria, Sylvance O Okoth   +10 more
doaj   +2 more sources

An evaluation of African animal trypanosomiasis control strategies in remote communities of Eastern Zambia [PDF]

Parasitology
Communities living in African animal trypanosomiasis (AAT) endemic areas of Zambia use several control strategies to protect their livestock from the devastating effects of trypanosomiasis.
Gloria M. Mulenga, Kalinga Chilongo, Chrisborn Mubamba, Bruce Gummow   +3 more
doaj   +2 more sources

Genomic analysis of Isometamidium Chloride resistance in Trypanosoma congolense [PDF]

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Isometamidium Chloride (ISM) is one of the principal drugs used to counteract Trypanosoma congolense infection in livestock, both as a prophylactic as well as a curative treatment. However, numerous cases of ISM resistance have been reported in different
Eliane Tihon, Hideo Imamura, Frederik Van den Broeck, Lieve Vermeiren, Jean-Claude Dujardin, Jan Van Den Abbeele   +5 more
doaj   +4 more sources

An Update on African Trypanocide Pharmaceutics and Resistance [PDF]

Frontiers in Veterinary Science, 2022
African trypanosomiasis is associated with Trypanosoma evansi, T. vivax, T. congolense, and T. brucei pathogens in African animal trypanosomiasis (AAT) while T. b gambiense and T.
Keneth Iceland Kasozi, Keneth Iceland Kasozi, Ewan Thomas MacLeod, Ibrahim Ntulume, Susan Christina Welburn, Susan Christina Welburn   +5 more
doaj   +2 more sources

High prevalence of Trypanosoma spp. and apparent trypanocidal drugs inefficacy in cattle in Al Radom National Park, Sudan [PDF]

Scientific Reports
Trypanosomosis is a major infectious disease affecting cattle in Sudan. In South Darfur, data on cattle trypanosomosis has been limited since the Darfur civil war (2003–2007). This study assessed the prevalence and distribution of Trypanosoma spp.
Khalid M. Mohammedsalih, Maowia M. Mukhtar, Abdoelnaim I. Y. Ibrahim, Ibrahim M. I. Mohammedain, Fathel-Rahman Juma, Abdelrahim A. Ali, Elwaleed M. Elamin, Ahmed Bashar, Georg von Samson-Himmelstjerna, Jürgen Krücken   +9 more
doaj   +2 more sources

Outbreak of Trypanosoma vivax in Dairy Cows: Hematologic, Immunological and Antioxidant Responses Before and After Treatment with Isometamidium Chloride [PDF]

Pathogens
Trypanosoma vivax infection is an emerging condition that causes damage and mortality among cattle and is transmitted by mechanical vectors or contaminated fomites. This disease has been spreading in southern Brazil, causing anemia, weight loss, diarrhea,
Alexandro Fritzen, Maksuel Gatto de Vitt, Guilherme Luiz Deolindo, Mateus Henrique Signor, Nathalia Gemelli Correa, Brenda Guedes Ribeiro, Julia Marques, Gabriella Bassi das Neves, Luiz Claudio Miletti, Aleksandro Schafer da Silva   +9 more
doaj   +2 more sources