Results 41 to 50 of about 475 (151)

In Vitro Uptake of Isometamidium and Diminazene by Trypanosoma brucei [PDF]

Antimicrobial Agents and Chemotherapy, 1974
The cattle trypanocide, isometamidium, was readily taken up by inactivated Trypanosoma brucei , while its uptake by living parasites was reduced or inhibited by plasma. In both respects isometamidium differs from diminazene.
P, Girgis-Takla, D M, James
openaire   +2 more sources

Effect of time of treatment on the efficacy of trypanocides in rats experimentally infected with Trypanosoma brucei brucei

Notulae Scientia Biologicae, 2023
The effect of treatment time on the efficacy of trypanocides in rats experimentally infected with Trypanosoma brucei brucei was assessed. The thirty albino rats utilized in this study were divided into six groups, each with five rats.
Ikenna O. EZEH, Chijioke N. IHEAGWAM, Chukunonso F. OBI, Michael I. OKPALA, Ganiyu E. ANERU, Charles O. AGBAEZE, Romanus C. EZEOKONKWO, Denchris ONAH   +7 more
doaj   +1 more source

Reduced accumulation of isometamidium by drug-resistant Trypanosoma congolense

Parasitology, 1991
The accumulation of the trypanocide isometamidium chloride (Samorin®, RMB Animal Health Ltd, UK) by a range of clones of Trypanosoma congolense with varying sensitivity to the drug, was measured by methods based on the fluorescence of isometamidium. Fluorescence microscopy and flow cytometry showed a reduction in drug accumulation by resistant clones ...
Sutherland, I.A., Peregrine, A.S., Lonsdale-Eccles, J.D., Holmes, P.H.   +3 more
openaire   +3 more sources

Antitrypanosomal Effects of Zanthoxylum zanthoxyloides (Lam.) Zepern. & Timler Extracts on African Trypanosomes

Evidence-Based Complementary and Alternative Medicine, Volume 2019, Issue 1, 2019., 2019
African trypanosomiasis is a disease caused by the parasitic protozoa of the Trypanosoma genus. Despite several efforts at chemotherapeutic interventions, the disease poses serious health and economic concerns to humans and livestock of many sub‐Saharan African countries. Zanthoxylum zanthoxyloides (Lam.) Zepern. & Timler (Z.
Aboagye Kwarteng Dofuor, Georgina Isabella Djameh, Frederick Ayertey, Peter Bolah, Michael Amoa-Bosompem, Kwaku Kyeremeh, Laud Kenneth Okine, Theresa Manful Gwira, Mitsuko Ohashi, Filippo Maggi   +9 more
wiley   +1 more source

Generation of Monoclonal Antibodies to the Anti-Trypanosomal Drug Isometamidium

Hybridoma, 1994
Mice were immunized with either an isometamidium-human serum albumin (HSA) conjugate or an isometamidium-porcine thyroglobulin conjugate (PTG). Thereafter, monoclonal antibodies (MAbs) IL-A 1001, IL-A 1002, IL-A 1003, 5F7.B7, and 5F7.C9 were generated and selected on the basis that they recognized conjugated and unconjugated isometamidium, but lacked ...
Peregrine, A.S., Eisler, M.C., Katende, J., Flynn, J.N., Gault, E.A., Kinabo, L.D.B., Holmes, P.H.   +6 more
openaire   +2 more sources

Parasitological, Hematological, and Immunological Response of Experimentally Infected Sheep with Venezuelan Isolates of Trypanosoma evansi, Trypanosoma equiperdum, and Trypanosoma vivax

Journal of Parasitology Research, Volume 2019, Issue 1, 2019., 2019
There are three trypanosoma species of veterinary importance in South America: (1) Trypanosoma evansi, the causative agent of derrengadera mechanically transmitted by bloodsucking insects such as tabanids, (2) Trypanosoma vivax, also mechanically transmitted by some dipteras hematophages as tabanids and/or Stomoxys, and (3) T.
Nereida Parra-Gimenez, Armando Reyna-Bello, José F. Silveira   +2 more
wiley   +1 more source

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): Trypanosoma evansi infections (including Surra)

EFSA Journal, Volume 15, Issue 7, July 2017., 2017
Abstract Trypanosoma evansi infections (including Surra) have been assessed according to the criteria of the Animal Health Law (AHL), in particular criteria of Article 7 on disease profile and impacts, Article 5 on the eligibility of T. evansi infections (including Surra) to be listed, Article 9 for the categorisation of T. evansi infections (including
EFSA Panel on Animal Health and Welfare (AHAW), Simon More, Anette Bøtner, Andrew Butterworth, Paolo Calistri, Klaus Depner, Sandra Edwards, Bruno Garin‐Bastuji, Margaret Good, Christian Gortázar Schmidt, Virginie Michel, Miguel Angel Miranda, Søren Saxmose Nielsen, Mohan Raj, Liisa Sihvonen, Hans Spoolder, Jan Arend Stegeman, Hans‐Hermann Thulke, Antonio Velarde, Preben Willeberg, Christoph Winckler, Francesca Baldinelli, Alessandro Broglia, Denise Candiani, Beatriz Beltrán Beck, Lisa Kohnle, Joana Morgado, Dominique Bicout   +27 more
wiley   +1 more source

Note sur la toxicité de l'Isométamidium par injection intraveineuse chez quelques mammifères domestiques et spécialement chez le dromadaire

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1977
Le chlorhydrate de chlorure d'Isométamidium est très mal supporté par le dromadaire à des doses supérieures à 1 mg/kg administrées par la voie ...
J. Balis
doaj   +1 more source

Trypanosoma evansi and Surra: A Review and Perspectives on Origin, History, Distribution, Taxonomy, Morphology, Hosts, and Pathogenic Effects

BioMed Research International, Volume 2013, Issue 1, 2013., 2013
Trypanosoma evansi, the agent of “surra,” is a salivarian trypanosome, originating from Africa. It is thought to derive from Trypanosoma brucei by deletion of the maxicircle kinetoplastic DNA (genetic material required for cyclical development in tsetse flies).
Marc Desquesnes, Philippe Holzmuller, De-Hua Lai, Alan Dargantes, Zhao-Rong Lun, Sathaporn Jittaplapong, Jude M. Przyborski   +6 more
wiley   +1 more source

Haematological indices in Trypanosoma brucei brucei (Federe isolate) infected Nigerian donkeys (Equus asinus) treated with homidium and isometamidium chloride of ciprofloxacin in broiler chickens after single intravenous and intraingluvial administration [PDF]

Macedonian Veterinary Review, 2017
The efficacy of intramuscular administration of Homidium chloride (Novidium®) and Isometamidium chloride (Sécuridium®) in Nigerian donkeys (Equus asinus) experimentally infected with T. b. brucei (Federe isolate) was investigated.
Queen Nneka Oparah, Anthony Bedu kojo Sackey, Idris Alao Lawal, Abdurrahman Hassan Jibril, Usman Shehu Abdullahi   +4 more
doaj   +1 more source