Results 41 to 50 of about 1,450 (197)
International Journal for Parasitology: Drugs and Drug Resistance, 2018 Trypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock that causes severe economic losses.
M. Gysin +5 more
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Revista Brasileira de Parasitologia Veterinária, 2021 Trypanosoma vivax infections cause nonspecific clinical signs in cattle associated with aparasitemic intervals, making disease diagnosis a challenge.
Kayo José Garcia de Almeida Castilho Neto +7 more
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Onderstepoort Journal of Veterinary Research, 2005 Resistance to trypanocidal drugs has been detected in various African countries and is a serious impediment to the control of livestock trypanosomosis.
S. Jamal +6 more
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Onderstepoort Journal of Veterinary Research, 2004 The protective efficacy of isometamidium chloride (ISMM) and diminazene aceturate (DIM) against Trypanosoma brucei, Trypanosoma congolense and Trypanosoma vivax infections in cattle under a suppressed tsetse population was assessed in southeast Uganda.
J.W. Magona +3 more
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Aberrant use and poor quality of trypanocides: a risk for drug resistance in south western Ethiopia
BMC Veterinary Research, 2018 Background Trypanocidal drugs have been used to control African animal trypanosomosis for several decades. In Ethiopia, these drugs are available from both authorized (legal) and unauthorized (illegal) sources but documentation on utilization practices ...
T. Tekle +14 more
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Notulae Scientia Biologicae, 2023 The effect of treatment time on the efficacy of trypanocides in rats experimentally infected with Trypanosoma brucei brucei was assessed. The thirty albino rats utilized in this study were divided into six groups, each with five rats.
Ikenna O. EZEH +7 more
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In Vitro Uptake of Isometamidium and Diminazene by Trypanosoma brucei [PDF]
Antimicrobial Agents and Chemotherapy, 1974 The cattle trypanocide, isometamidium, was readily taken up by inactivated Trypanosoma brucei , while its uptake by living parasites was reduced or inhibited by plasma. In both respects isometamidium differs from diminazene.
P, Girgis-Takla, D M, James
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Reduced accumulation of isometamidium by drug-resistant Trypanosoma congolense
Parasitology, 1991 The accumulation of the trypanocide isometamidium chloride (Samorin®, RMB Animal Health Ltd, UK) by a range of clones of Trypanosoma congolense with varying sensitivity to the drug, was measured by methods based on the fluorescence of isometamidium. Fluorescence microscopy and flow cytometry showed a reduction in drug accumulation by resistant clones ...
Sutherland, I.A. +3 more
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Evidence-Based Complementary and Alternative Medicine, Volume 2019, Issue 1, 2019., 2019 African trypanosomiasis is a disease caused by the parasitic protozoa of the Trypanosoma genus. Despite several efforts at chemotherapeutic interventions, the disease poses serious health and economic concerns to humans and livestock of many sub‐Saharan African countries. Zanthoxylum zanthoxyloides (Lam.) Zepern. & Timler (Z.
Aboagye Kwarteng Dofuor +9 more
wiley +1 more source
Generation of Monoclonal Antibodies to the Anti-Trypanosomal Drug Isometamidium
Hybridoma, 1994 Mice were immunized with either an isometamidium-human serum albumin (HSA) conjugate or an isometamidium-porcine thyroglobulin conjugate (PTG). Thereafter, monoclonal antibodies (MAbs) IL-A 1001, IL-A 1002, IL-A 1003, 5F7.B7, and 5F7.C9 were generated and selected on the basis that they recognized conjugated and unconjugated isometamidium, but lacked ...
Peregrine, A.S. +6 more
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