Results 1 to 10 of about 54,835 (196)

Evaluation of High-Dose Isoniazid in Multidrug-Resistant Tuberculosis Treatment [PDF]

Emerging Infectious Diseases
High-dose isoniazid is recommended to treat multidrug-resistant tuberculosis (MDR TB). Among 958 MDR TB isolates identified in France during 2008–2022, 93.1% exhibited high-level isoniazid resistance, and molecular testing showed limited diagnostic ...
Valentina Gerussi, Tania Petersen, Isabelle Bonnet, Alexandra Aubry, Marwa Bachir, Esther Gyde, Florence Morel, Corentin Poignon, Brigitte Rached, Valérie Pourcher, Christophe Rioux, Dorothée Vallois, Nicolas Veziris, Jérôme Robert, Lorenzo Guglielmetti   +14 more
doaj   +2 more sources

Determination of Isoniazid by Fe(II)-2,2’-Bipyridine Spectrophotometry [PDF]

E3S Web of Conferences, 2021
In acidic media, Fe(Ш) could be reduced to Fe(Ⅱ) by isoniazid, Fe(Ⅱ) reacts with 2,2'-bipyridine to form an orange complex with a maximum absorption wavelength of 522 nm. According to this principle, the content of isoniazid can be measured indirectly by
Tu Changqing, Wen Xinrong
doaj   +1 more source

Pyrazinamide resistance in rifampicin discordant tuberculosis.

PLoS ONE, 2022
IntroductionMycobacterium tuberculosis strains with phenotypically susceptible rpoB mutations (rifampicin discordant) have emerged following implementation of rapid molecular drug resistance testing for tuberculosis. Whilst rifampicin resistance is known
Nomonde Ritta Mvelase, Ravesh Singh, Khine Swe Swe-Han, Koleka Patience Mlisana   +3 more
doaj   +2 more sources

The Effects of Isoniazid on the Acquisition and Expression of Morphine-Induced Conditioned Place Preference in Mice [PDF]

Journal of Kerman University of Medical Sciences, 2020
Background: GABAergic drugs can modulate the rewarding properties of morphine. The objective of this study was to evaluate the effects of isoniazid, as a GABAergic agent, on the rewarding effects of morphine.
Amir Barzegari, Kamran Shahabi
doaj   +1 more source

Prevalence, risk factors and treatment outcomes of isoniazid resistant TB in Bulawayo city, Zimbabwe: A cohort study

Journal of Infection in Developing Countries, 2020
Introduction: The isoniazid-resistant TB poses a threat to TB control efforts. Zimbabwe, one of the high TB burden countries, has not explored the burden of isoniazid resistant TB.
Barbara Manyame-Murwira, Kudakwashe Collins Takarinda, Pruthu Thekkur, Bright Payera, Herbert Mutunzi, Raiva Simbi, Nicholas Siziba, Edwin Sibanda, Catherine Banana, Norbert Muleya, Evidence Makombe, Paula Littia Jongwe, Regina Bhebhe, Douglas Mangwanya, Janet Dzangare, Fungai Hamilton Mudzengerere, Collins Timire, Enock Wekiya, Charles Sandy   +18 more
doaj   +1 more source

Barriers in the implementation of isoniazid preventive therapy for people living with HIV in Northern Ethiopia: a mixed quantitative and qualitative study

BMC Public Health, 2016
Background Isoniazid preventive therapy is a key public health intervention for the prevention of tuberculosis disease among people living with HIV. Despite the confirmed efficacy of isoniazid preventive therapy and global recommendations existing for ...
Gebrehiwot Teklay, Tsigemariam Teklu, Befikadu Legesse, Kiros Tedla, Eveline Klinkenberg   +4 more
doaj   +1 more source

Chronic dialysis, NAT2 polymorphisms, and the risk of isoniazid-induced encephalopathy – case report and literature review

BMC Nephrology, 2017
Background Isoniazid is the most widely used anti-tuberculosis agent, yet it may lead to life-threatening complications. Case presentation Here we report the case of a chronic hemodialysis patient who developed severe encephalopathy after the start of ...
Stefan Matei Constantinescu, Benoit Buysschaert, Vincent Haufroid, Franck Broly, Michel Jadoul, Johann Morelle   +5 more
doaj   +1 more source

Redox Imbalance and Oxidative DNA Damage During Isoniazid Treatment of HIV-Associated Tuberculosis: A Clinical and Translational Pharmacokinetic Study

Frontiers in Pharmacology, 2020
BackgroundThe potential for hepatotoxicity during isoniazid-based tuberculosis (TB) treatment presents a major challenge for TB control programs worldwide.
Isaac Zentner, Hyun-moon Back, Leonid Kagan, Selvakumar Subbian, Jyothi Nagajyothi, Shashikant Srivastava, Jotam Pasipanodya, Tawanda Gumbo, Gregory P. Bisson, Christopher Vinnard   +9 more
doaj   +1 more source

Uji Kepekaan Mycobacterium sp. terhadap Isoniazid (INH) Menggunakan Metode Rasio Resistensi secara In Vitro

Mutiara Medika, 2013
Infeksi mikobakteria termasuk diantara infeksi yang paling sulit disembuhkan dari semua jenis infeksi bakteri. Mikobakteria yang patogen utamanya adalah Mycobacterium tuberculosis sebagai penyebab tuberkulosis (TB), yang mengakibatkan lebih banyak ...
Dwi Yuni Nur Hidayati, Roekistiningsih Roekistiningsih   +1 more
doaj   +1 more source

Protective effects of salep against isoniazid liver toxicity in wistar rats

Journal of Traditional and Complementary Medicine, 2018
Introduction: Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis.
Hossein Kargar Jahromi, Morteza Pourahmad, Hassan Ali Abedi, Mohadeseh karimi, Zahra Kargar Jahromi   +4 more
doaj   +1 more source