Results 101 to 110 of about 13,872 (224)
The isoprenoid-precursor dependence of Plasmodium spp. [PDF]
, 2012 Due to the increase in resistance of Plasmodium spp. against available antimalarials, there is a need for new, effective and innovative drugs. The non-mevalonate pathway for the biosynthesis of the universal isoprenoid precursors, which is absent in ...
Meer, Jan-Ytzen van der, +3 more
core +1 more source
Synthetic and Systems Biotechnology, 2018 The isoprenoid brasilicardin A is a promising immunosuppressant compound with a unique mode of action, high potency and reduced toxicity compared to today's standard drugs.
Paul N. Schwarz +4 more
doaj +1 more source
Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.This review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Daisuke Fujinami +2 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 11, 15 June 2026.L‐malic acid, a natural TCA cycle intermediate, attenuates the virulence of Staphylococcus aureus through dual metabolic and regulatory mechanisms. It redirects central carbon flux away from the mevalonate pathway and inhibits the key enzyme CrtO, suppressing staphyloxanthin biosynthesis and impairing bacterial resistance to oxidative stress ...
Li Shen +11 more
wiley +1 more source
Molecular basis of isoprenoid biosynthesis in Dunaliella salina [PDF]
, 2009 Tese dout., Ciências do Mar, Universidade do Algarve, 2009Fundação para a Ciência e Tecnologia ...
Ramos, A. A., Ramos, Ana
core
The Biosynthesis of Isoprenoids and the Mechanisms Regulating It in Plants
Bioscience, Biotechnology, and Biochemistry, 2011 Plants synthesize isopentenyl diphosphate (IPP) via the mevalonate pathway and the methylerythritol phosphate (MEP) pathway. IPP is condensed to its allylic isomer, dimethylallyl diphosphate, to yield geranylgeranyl diphosphate, a common precursor for the production of cyclic diterpenoids.
openaire +2 more sources
Comparative analysis of the biosynthesis of isoprenoid and aromatic cytokinins
Доклады Академии наук, 2019 To compare the biosynthesis pathways of aromatic and isoprenoid cytokinins, a series of nucleoside derivatives of natural cytokinins was synthesized and their cytokinin activity was determined in a test system based on the model plant Arabidopsis thaliana. Cytokinin nucleosides are known to lack the hormonal activity until cleaving the ribose moiety at
V E, Oslovsky +4 more
openaire +3 more sources
FEBS Letters, Volume 600, Issue 11, Page 1621-1637, June 2026.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
PLoS ONE, 2014 A novel xanthomonadin-dialkylresorcinol hybrid named arcuflavin was identified in Azoarcus sp. BH72 by a combination of feeding experiments, HPLC-MS and MALDI-MS and gene clusters encoding the biosynthesis of this non-isoprenoid aryl-polyene containing ...
Tim A Schöner +3 more
doaj +1 more source
HDR, the last enzyme in the MEP pathway, differently regulates isoprenoid biosynthesis in two woody plants. [PDF]
Plant Physiol, 2023 Krause T +9 more
europepmc +1 more source