Results 111 to 120 of about 13,872 (224)

HDL‐mimetic peptide treatment reverses APOE4‐induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD). ApoE4 has reduced lipidation capacity and impaired lipid transport, disrupting neuronal maintenance. The high‐density lipoprotein (HDL)‐mimetic peptide 4F offers a potential therapeutic strategy.
Allison Chang, Minwoo Kim, Matthew Glittenberg, Wenhui Qu, Danni Li, Ling Li   +5 more
wiley   +1 more source

THE ISOPRENOID BIOSYNTHESIS DURING TUBER BORCHII FRUIT BODY MATURATION

, 2010
The first insight into T. borchii isoprenoid pathway, also known as mevalonic acids pathway (MVA) during ascoma maturation were here discussed . Three genes coding for the most important enzymes of the isoprenoid biosynthesis were characterised, and the ...
Zeppa S., Guidi C., ZAMBONELLI, ALESSANDRA, Annibalini G., Gioacchini A. M., Potenza L., Guescini M., Stocchi V.   +7 more
core  

Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines

Journal of Lipid Research, 1998
ZR-78 and ZR-82 cells are two peroxisomal-deficient Chinese hamster ovary (CHO) cell mutants. These cells lack normal peroxisomes and show reduced levels of plasmalogen synthesis and other peroxisomal functions attributed to the deficiency of peroxisomal
Nahla Aboushadi, Skaidrite K. Krisans
doaj   +1 more source

Functional Metagenomics Insights Into the Allium ampeloprasum Rhizosphere Microbiome Under Different Fertilization Regimes

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Shotgun metagenomic sequencing was used to characterize the functional potential of the Allium ampeloprasum rhizosphere microbiome under chemical fertilizer (G1), biofertilizer (G2), and unfertilized (Bulk) soil (G3) management practices. This study revealed that different fertilization regimes altered microbial functional profiles.
Oluwaseun Emmanuel Shittu, Ben Jesuorsemwen Enagbonma, Olubukola Oluranti Babalola   +2 more
wiley   +1 more source

Isoprenoidquantifizierung in Hirngewebe - cerebrale Regulation von FPP und GGPP bei Morbus Alzheimer und im Alter

, 2011
Over the last years there has been an increasing interest in the involvement of the MVA-pathway and of members of the small GTPases, in the development and progression of AD.
Hooff, Gero P.
core  

Incorporation of Nonmethyl Branches by Isoprenoid-like Logic: Multiple β-Alkylation Events in the Biosynthesis of Myxovirescin A1

, 2007
SummarySeveral polyketide secondary metabolites are predicted to undergo isoprenoid-like β-alkylations during biosynthesis. One such secondary metabolite is myxovirescin A1, produced by Myxococcus xanthus.
Calderone, Christopher T., Kelleher, Neil L., Iwig, David F., Dorrestein, Pieter C., Walsh, Christopher T.   +4 more
core   +1 more source

A transcriptional analysis of carotenoid, chlorophyll and plastidial isoprenoid biosynthesis genes during development and osmotic stress responses in Arabidopsis thaliana [PDF]

, 2011
Background The carotenoids are pure isoprenoids that are essential components of the photosynthetic apparatus and are coordinately synthesized with chlorophylls in chloroplasts.
Tzfadia, Oren, Oren Tzfadia, Chris Gehring, Eleanore T Wurtzel, Stuart Meier, Meier, Stuart, Vallabhaneni, Ratnakar, Ratnakar Vallabhaneni, Wurtzel, Eleanore T, Gehring, Chris   +9 more
core   +1 more source

Five questions about non-mevalonate isoprenoid biosynthesis. [PDF]

PLoS Pathogens, 2011
Audrey R Odom
doaj   +1 more source

Correction: Differential Subplastidial Localization and Turnover of Enzymes Involved in Isoprenoid Biosynthesis in Chloroplasts. [PDF]

PLoS One, 2022
Perello C, Llamas E, Burlat V, Ortiz-Alcaide M, Phillips MA, Pulido P, Rodriguez-Concepcion M.   +6 more
europepmc   +1 more source

Aphid alarm pheromone (E)‐β‐farnesene: mechanisms, applications, and challenges in pest management

New Plant Protection, Volume 3, Issue 2, June 2026.
This review highlights the advances in the application of the aphid alarm pheromone (E)‐β‐farnesene (EβF) for pest management. It focuses on smart delivery systems, molecular optimization, synthetic biology, and integration with digital agriculture. Additionally, it discusses key challenges and future directions for enhancing stability, field efficacy,
Yi Yan, Yunhui Zhang, Xuguo Zhou, Xiangrui Li   +3 more
wiley   +1 more source