Results 121 to 130 of about 13,872 (224)

Metabolic flux ratio analysis by parallel ¹³C labeling of isoprenoid biosynthesis in Rhodobacter sphaeroides

, 2020
Metabolic engineering for increased isoprenoid production often benefits from the simultaneous expression of the two naturally available isoprenoid metabolic routes, namely the 2-methyl-D-erythritol 4-phosphate (MEP) pathway and the mevalonate (MVA ...
Beekwilder, Jules, Eggink, Gerrit, Kengen, Servé W.M., Orsi, Enrico, Peek, Siebe, Weusthuis, Ruud A.   +5 more
core   +1 more source

EalspF1, Essential Enzyme in Isoprenoid Biosynthesis from Eupatorium adenophorum, Reveals a Novel Role in Light Acclimation

Journal of Integrative Agriculture, 2014
Isoprenoids are a functionally and structurally diverse class of natural organic chemicals. The universal precursors of all isoprenoids, isopentenyl diphosphate and dimethylallyl diphosphate are synthesized through the mevalonate and 2C-methyl-D ...
Sheng-rui ZHANG, Xue JIANG, Ping WANG, Di WU, Qing-hua WANG, Yu-xia HOU   +5 more
doaj   +1 more source

Umbelliprenin in Food and Medicinal Plants: Phytochemical Occurrence, Biosynthesis, Analytical Approaches, and Biological Activities

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
This review provides an extensive and critical synthesis of current knowledge on umbelliprenin, integrating phytochemical, analytical, biological, ecological, and food science perspectives, and identifies priorities for future research. ABSTRACT Umbelliprenin (7‐farnesyloxycoumarin) is an oxyprenylated coumarin that has gained increasing attention in ...
Chiara Collevecchio, Lorenzo Marchetti, Francesco Epifano, Salvatore Genovese, Serena Fiorito   +4 more
wiley   +1 more source

Nicotiana benthamiana as a Production Platform for Artemisinin Precursors

, 2010
Background Production of pharmaceuticals in plants provides an alternative for chemical synthesis, fermentation or natural sources. Nicotiana benthamiana is deployed at commercial scale for production of therapeutic proteins.
Herpen, T.W.J.M., van, Nogueira, M., Teun W J M van Herpen, van Herpen Teun W. J. M., Harro J. Bouwmeester, Cankar, Katarina, Katarina Cankar, Harpen, Teun W. J. M. van, Marilise Nogueira, Dirk Bosch, Harro J Bouwmeester, Bouwmeester Harro J., Beekwilder, Jules, Jules Beekwilder, Teun W. J. M. van Herpen, Nogueira Marilise, Cankar, K., van Herpen, T.W.J.M., Cankar Katarina, Beekwilder Jules, Bouwmeester, Harro, Nogueira, Marilise, Bosch, H.J., Bosch Dirk, Bouwmeester, H.J., Beekwilder, M.J., Bosch, Dirk   +26 more
core   +1 more source

Deciphering the properties and reaction mechanism of anhydromevalonate phosphate decarboxylase, a prenylated flavin mononucleotide‐dependent enzyme in the archaeal mevalonate pathway

The FEBS Journal, Volume 293, Issue 11, Page 3303-3319, June 2026.
Characterization of anhydromevalonate phosphate decarboxylase, the UbiD‐family decarboxylase involved in the archaeal mevalonate pathway, was conducted. The enzyme is responsible for the biosynthesis of isoprenoids, such as archaeal membrane lipids, respiratory quinones, and dolichols.
Rino Ishikawa, Natsumi Matsushima, Soma Ishimine, Honoka Nakamoto, Hajime Hayakawa, Yoko Yasuno, Tetsuro Shinada, Hiroshi Kawaide, Tomokazu Ito, Hisashi Hemmi   +9 more
wiley   +1 more source

Apicoplast-derived isoprenoids are essential for biosynthesis of GPI protein anchors, and consequently for egress and invasion in Plasmodium falciparum.

PLoS Pathogens
Glycophosphatidylinositol (GPI) anchors are the predominant glycoconjugate in Plasmodium parasites, enabling modified proteins to associate with biological membranes.
Michaela S Bulloch, Long K Huynh, Kit Kennedy, Julie E Ralton, Malcolm J McConville, Stuart A Ralph   +5 more
doaj   +1 more source

Exploring the Isoprenoid Biosynthesis Pathway’s Role in Oncogenic Viruses

Viruses
Oncogenic viruses, which are causative for some cancers, are typically acquired in youth and suppressed until older age. These malignancies account for over 10% of the cancer burden and often reprogram cellular metabolic pathways to promote their own ...
Louise N. Blaha, Jeffrey D. Neighbors, Richa Sandeep, Akhila Kondaka, Raymond J. Hohl   +4 more
doaj   +1 more source

3-Hydroxy-3-methylglutaryl coenzyme A reductase genes from Glycine max regulate plant growth and isoprenoid biosynthesis. [PDF]

Sci Rep, 2023
Wang S, Feng Y, Lou Y, Niu J, Yin C, Zhao J, Du W, Yue A.   +7 more
europepmc   +1 more source

Phylogenetic history shapes the composition of floral scents in a specialized pollination mutualism

New Phytologist, Volume 250, Issue 5, Page 3428-3443, June 2026.
Summary Most studies of the chemical ecology of plant–pollinator interactions emphasize the role of pollinator‐mediated selection in shaping floral scent composition. Nevertheless, phylogeny may constrain the metabolic pathways underlying these profiles, thereby influencing the evolutionary trajectory of the emitted signals.
Li Cao, Nina Joffard, Simon T. Segar, Daniel Souto‐Vilarós, Steven D. Johnson, Bruno Buatois, Anne‐Geneviève Bagnères, Martine Hossaert‐McKey, Magali Proffit   +8 more
wiley   +1 more source

Targeting isoprenoid biosynthesis for drug discovery [PDF]

, 2013
Cancer and infectious diseases are huge threats to human beings. With the rapid rise in drug resistance, there is a need for new drugs, and isoprenoid biosynthesis is an attractive target for drug discovery.
Zhu, Wei
core