Results 141 to 150 of about 12,755 (182)
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Screening for improved isoprenoid biosynthesis in microorganisms
Journal of Biotechnology, 2016The production of isoprenoids in recombinant microbes for flavor & fragrance, pharmaceutical, agricultural or fuel applications is a booming research field. Isoprenoid extraction from natural resources and chemical synthesis is frequently neither ecological nor commercially profitable.
Anita, Emmerstorfer-Augustin +2 more
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Biosynthesis of Isoprenoid Compounds
Annual Review of Biochemistry, 1961Sir Alexander Todd has recently stated (1): "The unravelling of the actual biosyn thetic pathway to the terpen ids and the sterols is one of the outstand ing achievements of recent years." It is now possible to write every reaction and name every intermediate in the biosynthesis of cholesterol from acetate with a reasonable degree of certainty.
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Metabolic plasticity for isoprenoid biosynthesis in bacteria
Biochemical Journal, 2013Isoprenoids are a large family of compounds synthesized by all free-living organisms. In most bacteria, the common precursors of all isoprenoids are produced by the MEP (methylerythritol 4-phosphate) pathway. The MEP pathway is absent from archaea, fungi and animals (including humans), which synthesize their isoprenoid precursors using the completely ...
Pérez-Gil, Jordi +1 more
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Biosynthesis of isoprenoid compounds in Schistosoma mansoni
Molecular and Biochemical Parasitology, 1993The isoprenoid biosynthetic capacity of digenetic trematodes was investigated by following the fate of [14C]mevalonic acid incorporated by Schistosoma mansoni during maintenance in axenic culture. Isoprenoid compounds were analyzed by thin-layer chromatography and high-performance liquid chromatography.
J M, Foster +3 more
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Central role of peroxisomes in isoprenoid biosynthesis
Progress in Lipid Research, 2002Peroxisomes contain enzymes catalyzing a number of indispensable metabolic functions mainly related to lipid metabolism. The importance of peroxisomes in man is stressed by the existence of genetic disorders in which the biogenesis of the organelle is defective, leading to complex developmental and metabolic phenotypes. The purpose of this review is to
Werner J, Kovacs +2 more
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Isoprenoid Biosynthesis of the Apicoplast as Drug Target
Current Drug Targets, 2007In Plasmodium falciparum the biosynthesis of isoprenoids is achieved by the mevalonate-independent 1-deoxy-d-xylulose 5-phosphate (DOXP) pathway. The enzymes of the DOXP pathway are localised inside the plastid-like organelle (apicoplast). Fosmidomycin inhibits DOXP reductoisomerase, the second enzyme of this pathway.
Jochen, Wiesner, Hassan, Jomaa
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Biosynthesis and engineering of isoprenoid small molecules
Applied Microbiology and Biotechnology, 2007Isoprenoid secondary metabolites are a rich source of commercial products that have not been fully explored. At present, there are isoprenoid products used in cancer therapy, the treatment of infectious diseases, and crop protection. All isoprenoids share universal prenyl diphosphate precursors synthesized via two distinct pathways.
Sydnor T, Withers, Jay D, Keasling
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Isoprenoid biosynthesis in Archaea – Biochemical and evolutionary implications
Research in Microbiology, 2011Isoprenoids are indispensable for all types of cellular life in the Archaea, Bacteria, and Eucarya. These membrane-associated molecules are involved in a wide variety of vital biological functions, ranging from compartmentalization and stability, to protection and energy-transduction.
Matsumi, R. +3 more
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Isoprenoid-like alkylations in polyketide biosynthesis
Natural Product Reports, 2008Polyketides are secondary metabolites biosynthesized by the iterative Claisen condensation of malonate units. Despite utilizing only a small set of biochemical transformations, the polyketide biosynthetic machinery yields products of striking structural complexity and diversity.
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Organization of isoprenoid biosynthesis
Biochemical Society Transactions, 1996I, Parmryd, G, Dallner
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