Screening of isoquinoline alkaloids for potent lipid metabolism modulation with Caenorhabditis elegans. [PDF]
, 2013 Metabolic syndrome and related disorders are increasingly prevalent in contemporary society, and thus pose the need for potent agents to control lipid accumulation in the body.
Chow, Yit-Lai, Sato, Fumihiko
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Ximenia americana L. From Popular Use to Anti‐Inflammatory Activities: A Comprehensive Review
Food Frontiers, Volume 7, Issue 2, March 2026.ABSTRACT Ximenia americana (L.), known as “yellow plum,” “sea lemon,” or “Brazilian plum,” is a tropical/subtropical plant widely used in traditional medicine. Its roots, leaves, flowers, stem, and fruits are traditionally employed to treat various inflammatory disorders.
Bruno Anderson F. Silva +9 more
wiley +1 more source
Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions
MedComm, Volume 7, Issue 2, February 2026.Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian +8 more
wiley +1 more source
Regioselective reactions of 3,4-pyridynes enabled by the aryne distortion model. [PDF]
, 2013 The pyridine heterocycle continues to play a vital role in the development of human medicines. More than 100 currently marketed drugs contain this privileged unit, which remains highly sought after synthetically. We report an efficient means to access di-
Garg, Neil K, Goetz, Adam E
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Synaptic tagging and capture : differential role of distinct calcium/calmodulin kinases in protein synthesis-dependent long-term potentiation [PDF]
, 2010 Weakly tetanized synapses in area CA1 of the hippocampus that ordinarily display long-term potentiation lasting ~3 h (called early-LTP) will maintain a longer-lasting change in efficacy (late-LTP) if the weak tetanization occurs shortly before or after ...
Bito, Haruhiko +5 more
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5,8-Di-tert-butyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione—A New Lipophilic N-oxyl Radical Precursor [PDF]
, 2023 Elena R. Lopat’eva +3 more
openalex +1 more source
Enzymatic formation of protopines by a microsomal cytochrome P-450 system of Corydalis vaginans [PDF]
, 1987 A microsomal cytochrome P-450-NADPH dependent enzyme which hydroxylates stereo- and regiospecifically carbon atom 14 of (S)- -N- methyltetrahydroprotoberberines has been discovered in a number of plant cell cultures originating from species containing ...
Rüffer, Martina, Zenk, Meinhart H.
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European Journal of Organic Chemistry, Volume 29, Issue 4, January 26, 2026.This review surveys recent progress in the synthesis of extended aromatic quinolizinium derivatives via intramolecular SNAr and oxidative 6π‐electrocyclization. Conventional thermal approaches are discussed alongside emerging, sustainable activation methods such as electrosynthesis and photochemical processes.
Marine Labro +2 more
wiley +1 more source
Synthesis of 5-bromonaphthalimide derivatives with 3-aminocycloalkanespiro-5-hydantoins [PDF]
BIO Web of ConferencesThe present work reports a study on the interaction of 5-bromo-1H,3H-naphtho[1,8-cd]pyran-1,3-dione with various 3-aminocycloalkanespiro-5-hydantoins, aimed at the development of new biologically active compounds.
Marinov Marin +2 more
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Catalytic Enantioselective Cross-Couplings of Secondary Alkyl Electrophiles with Secondary Alkylmetal Nucleophiles: Negishi Reactions of Racemic Benzylic Bromides with Achiral Alkylzinc Reagents [PDF]
, 2012 We have developed a nickel-catalyzed method for the asymmetric cross-coupling of secondary electrophiles with secondary nucleophiles, specifically, stereoconvergent Negishi reactions of racemic benzylic bromides with achiral cycloalkylzinc reagents.
Arp F. O. +38 more
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