Results 1 to 10 of about 15,657 (274)

C-1 Substituted isoquinolines potentiate the antimycobacterial activity of rifampicin and ethambutol [PDF]

Frontiers in Antibiotics, 2023
IntroductionThe emergence of extensively drug-resistant strains of Mycobacterium tuberculosis threatens decades of progress in the treatment of a disease which remains one of the leading infectious causes of death worldwide.
Liam T. Martin, Liam T. Martin, Eleanor D. Lamming, Arundhati Maitra, Parisa N. Mortazavi, Rebecca Roddan, Rebecca Roddan, John M. Ward, Sanjib Bhakta, Helen C. Hailes   +9 more
doaj   +3 more sources

Spasmolytic Activity of 1,3-Disubstituted 3,4-Dihydroisoquinolines [PDF]

Biomedicines
This article concerns the spasmolytic activities of some novel 1,3-disubstituted 3,4-dihydroisoquinolines. These compounds can be evaluated as potential therapeutic candidates according to Lipinski’s rule of five, showing high gastrointestinal absorption
Miglena Milusheva, Mihaela Stoyanova, Vera Gledacheva, Iliyana Stefanova, Mina Todorova, Stoyanka Nikolova   +5 more
doaj   +2 more sources

Rh(III)-Catalyzed Double Annulation of 3-Phenyl-1,2,4-oxadiazoles with 2-Diazo-1,3-diketones: Access to Pyran-Fused Isoquinolines [PDF]

Molecules
Efficient access to pyranoisoquinoline derivatives via rhodium-catalyzed double C-H functionalization of phenyl oxadiazoles and diazo compounds has been developed.
Enshen Zhang, Mei Sun, Lvlv Gao
doaj   +2 more sources

isoQUINOLINE DERIVATIVES. PART III [PDF]

, 1957
In contrast with the earlier observation (Ghosh and Dutta, this Journal, 1955, 32, 17, 755) that treat­ment of (a-acetamido-β-phenyl)-etbylmethyl ketone and of β-phenyl-substituted analogues with POCI3 or conc. H2SO4 leads to the formation of I-methylisoquinoline derivatives, accompanied with dehy­drogenation and deacetylation, (α-scetamido-β-phenyl ...
T. N. GHOSH, BHABATOSH BITATTACTIARYA, SAKTIPADA DATTA   +2 more
openalex   +4 more sources

Synthesis of spiroindolenines through a one-pot multistep process mediated by visible light [PDF]

Beilstein Journal of Organic Chemistry
Spiro-heterocyclic indolenines are privileged scaffolds widely present in numerous indole alkaloids. Here, we develop a novel approach for the one-pot multistep synthesis of different spiro[indole-isoquinolines].
Francesco Gambuti, Jacopo Pizzorno, Chiara Lambruschini, Renata Riva, Lisa Moni   +4 more
doaj   +2 more sources

Pyridine-based strategies towards nitrogen isotope exchange and multiple isotope incorporation [PDF]

Nature Communications
Isotopic labeling is at the core of health and life science applications such as nuclear imaging, metabolomics and plays a central role in drug development. The rapid access to isotopically labeled organic molecules is a sine qua non condition to support
Minghao Feng, Maylis Norlöff, Benoit Guichard, Steven Kealey, Timothée D’Anfray, Pierre Thuéry, Frédéric Taran, Antony Gee, Sophie Feuillastre, Davide Audisio   +9 more
doaj   +2 more sources

A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B

Molecules, 2022
Recent reports of antiepileptic activity of the fungal alkaloid TMC-120B have renewed the interest in this natural product. Previous total syntheses of TMC-120B comprise many steps and have low overall yields (11–17 steps, 1.5–2.9% yield).
Ahmad K. Haidar, Niels D. Kjeldsen, Nikolaj S. Troelsen, Viola Previtali, Kasper P. Lundquist, Thomas O. Larsen, Mads H. Clausen   +6 more
doaj   +1 more source

Synthesis of 5,6-Dihydropyrazolo[5,1-a]isoquinolines through Tandem Reaction of C,N-Cyclic Azomethine Imines with α,β-Unsaturated Ketones

Molecules, 2023
An innovative and efficient approach has been developed for the synthesis of 5,6-dihydropyrazolo[5,1-a]isoquinolines. This one-pot tandem reaction involves the reaction of C,N-cyclic azomethine imines with α,β-unsaturated ketones, using K2CO3 as the base
Young Jae Yun, Sung-Gon Kim
doaj   +1 more source

Electron-Deficient Acetylenes as Three-Modal Adjuvants in S_N^H Reaction of Pyridinoids with Phosphorus Nucleophiles

Molecules, 2021
Publications covering a new easy metal-free functionalization of pyridinoids (pyridines, quinolines, isoquinolines, acridine) under the action of the system of electron-deficient acetylenes (acetylenecarboxylic acid esters, acylacetylenes)/P-nucleophiles
Boris A. Trofimov, Pavel A. Volkov, Anton A. Telezhkin   +2 more
doaj   +1 more source

Recent Advances in the Synthesis of Isoquinoline-Fused Benzimidazoles

Molecules, 2022
This review includes recent developments in the synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines with particular attention given to categorizing protocols based on the structural features of the ring architecture and crystallographically characterized ...
Dylan J. Twardy, Kraig A. Wheeler, Béla Török, Roman Dembinski   +3 more
doaj   +1 more source