Results 1 to 10 of about 12,369 (209)

Synthesis of 1H-Pyrrolo[3,2-g]isoquinoline Derivatives as Ligands Targeting Haspin Kinase [PDF]

Molecules
A new series of 1H-pyrrolo[3,2-g]isoquinolines, diversely substituted at the 3-position either by a heteroaromatic scaffold or by propionate/acrylate side chains, were synthesized and evaluated as Haspin kinase inhibitors.
Killian Malosse, Béatrice Josselin, Sandrine Ruchaud, Fabrice Anizon, Francis Giraud, Pascale Moreau   +5 more
doaj   +2 more sources

Effects of a Synthetic Isoquinoline Derivative Against Ichthyophthirius multifiliis In Vivo and In Vitro in Grass Carp (Ctenopharyngodon idella) [PDF]

Pathogens
White spot disease, caused by the parasitic Ichthyophthirius multifiliis, induces mortality exceeding 80% in intensive aquaculture systems, resulting in global annual losses of >$1 billion.
Xianqi Peng, Xialian Bu, Weisong Ma, Jinbiao Jiao, Xiaohong Huang, Yu Zhao, Jian Zhu, Lei Huang, Jing Chen, A’qin Zheng, Huantao Qu, Jiayun Yao   +11 more
doaj   +2 more sources

Photoredox catalytic asymmetric dearomative [3 + 2] cycloaddition of isoquinolines with enones [PDF]

Nature Communications
Asymmetric dearomative photocycloaddition has emerged as a transformative strategy for the enantioselective construction of complex three-dimensional molecular architectures from simple planar aromatic precursors. While significant progress has been made
Jingjing Huo, Songwei Yang, Manman Kong, Miao Xi, Baokun Qiao, Zhiyong Jiang   +5 more
doaj   +2 more sources

Rh(III)-Catalyzed Double Annulation of 3-Phenyl-1,2,4-oxadiazoles with 2-Diazo-1,3-diketones: Access to Pyran-Fused Isoquinolines [PDF]

Molecules
Efficient access to pyranoisoquinoline derivatives via rhodium-catalyzed double C-H functionalization of phenyl oxadiazoles and diazo compounds has been developed.
Enshen Zhang, Mei Sun, Lvlv Gao
doaj   +2 more sources

Spasmolytic Activity of 1,3-Disubstituted 3,4-Dihydroisoquinolines [PDF]

Biomedicines
This article concerns the spasmolytic activities of some novel 1,3-disubstituted 3,4-dihydroisoquinolines. These compounds can be evaluated as potential therapeutic candidates according to Lipinski’s rule of five, showing high gastrointestinal absorption
Miglena Milusheva, Mihaela Stoyanova, Vera Gledacheva, Iliyana Stefanova, Mina Todorova, Stoyanka Nikolova   +5 more
doaj   +2 more sources

Silver-Mediated Electrosynthesis of Substituted Isoquinolines via Cyclization of 2‑Ethynylbenzaldehydes [PDF]

ACS Omega
Eliakin S. de Borba, Daniel C. A. Amélio, Kíssylla P. Gomes, Pedro P. de Castro, Fernando R. Xavier, Guilherme M. Martins, Kleber T. de Oliveira, Samuel R. Mendes   +7 more
doaj   +2 more sources

C-1 Substituted isoquinolines potentiate the antimycobacterial activity of rifampicin and ethambutol

Frontiers in Antibiotics, 2023
IntroductionThe emergence of extensively drug-resistant strains of Mycobacterium tuberculosis threatens decades of progress in the treatment of a disease which remains one of the leading infectious causes of death worldwide.
Liam T. Martin, Liam T. Martin, Eleanor D. Lamming, Arundhati Maitra, Parisa N. Mortazavi, Rebecca Roddan, Rebecca Roddan, John M. Ward, Sanjib Bhakta, Helen C. Hailes   +9 more
doaj   +1 more source

A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B

Molecules, 2022
Recent reports of antiepileptic activity of the fungal alkaloid TMC-120B have renewed the interest in this natural product. Previous total syntheses of TMC-120B comprise many steps and have low overall yields (11–17 steps, 1.5–2.9% yield).
Ahmad K. Haidar, Niels D. Kjeldsen, Nikolaj S. Troelsen, Viola Previtali, Kasper P. Lundquist, Thomas O. Larsen, Mads H. Clausen   +6 more
doaj   +1 more source

Synthesis of 5,6-Dihydropyrazolo[5,1-a]isoquinolines through Tandem Reaction of C,N-Cyclic Azomethine Imines with α,β-Unsaturated Ketones

Molecules, 2023
An innovative and efficient approach has been developed for the synthesis of 5,6-dihydropyrazolo[5,1-a]isoquinolines. This one-pot tandem reaction involves the reaction of C,N-cyclic azomethine imines with α,β-unsaturated ketones, using K2CO3 as the base
Young Jae Yun, Sung-Gon Kim
doaj   +1 more source

Organocatalytic Kinetic Resolution of Ferroceno[c]isoquinolines through Asymmetric Transfer Hydrogenation [PDF]

JACS Au
Yan-Jiang Yu, Zheng Liu, Yi-Qian Yang, Mu-Wang Chen, Rong-Zhen Liao, Yong-Gui Zhou   +5 more
doaj   +2 more sources