Results 101 to 110 of about 871 (158)
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Angewandte Chemie, 1963
AbstractDas Ringsystem der nicht annellierten 1.2‐Thiazole (=Isothiazole) ist erst in neuester Zeit zugänglich geworden. Vier Synthesen und zahlreiche Umsetzungen eröffnen neue Wege zu Verbindungen, die als Zwischenprodukte und Analoga zu Naturstoffen und bekannten Pharmazeutika Interesse beanspruchen.
F. Hübenett +4 more
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AbstractDas Ringsystem der nicht annellierten 1.2‐Thiazole (=Isothiazole) ist erst in neuester Zeit zugänglich geworden. Vier Synthesen und zahlreiche Umsetzungen eröffnen neue Wege zu Verbindungen, die als Zwischenprodukte und Analoga zu Naturstoffen und bekannten Pharmazeutika Interesse beanspruchen.
F. Hübenett +4 more
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Synthesis of Stable Isothiazole Carbenes
Angewandte Chemie International Edition, 2007Whereas stable imi-dazolyl-2- and 1,3-thiazol-2-ylidenes are accessible, isothia-zol-3-ylidenes4 could not beisolated until now.This isnotsurprising when one compares some thermodynamic andkineticcharacteristicsfortypicalcarbenereactionsof1,2,and4(R=H)estimatedbymeansofabinitiocalculations(forthedetails of the quantum chemical calculations, see the Sup-
Janine, Wolf +5 more
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Tetrahedron, 1969
Abstract A method has been devised whereby a substituted isoxazole (I) can be efficiently converted to an isothiazole (III) with a similar substitution pattern. The isoxazole ring is opened by reduction with Raney nickel, and the resulting enamino ketone (II) is treated with phosphorus pentasulfide and chloranil to give the corresponding isothiazole ...
D.N. McGregor +3 more
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Abstract A method has been devised whereby a substituted isoxazole (I) can be efficiently converted to an isothiazole (III) with a similar substitution pattern. The isoxazole ring is opened by reduction with Raney nickel, and the resulting enamino ketone (II) is treated with phosphorus pentasulfide and chloranil to give the corresponding isothiazole ...
D.N. McGregor +3 more
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ChemInform Abstract: ISOTHIAZOLE 15. MITT. 5‐NITRO‐ISOTHIAZOLE
Chemischer Informationsdienst, 1972AbstractDurch Diazotieren mit NO[SO4H] und anschließende Nitrierung mit NaNOz/ Cu(I)Cu(II)‐sulfit wird das Aminoisothiazol (I) in das Nitroderivat (II) übergefuhrt, das mit CrO3/H2SO4 zu der Carbonsäure (IIIa) oxidiert wird (widersteht der thermischen Decarboxylierung).
R. J. A. WALSH, K. R. H. WOOLDRIDGE
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Chemischer Informationsdienst, 1980
AbstractVerschiedene 2,3‐disubstituierte Thienophene wie z.B. (IVa) (Weiterführung in (IVb) und (IVc)) und (IVd) werden dargestellt.
K. CLARKE, W. R. FOX, R. M. SCROWSTON
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AbstractVerschiedene 2,3‐disubstituierte Thienophene wie z.B. (IVa) (Weiterführung in (IVb) und (IVc)) und (IVd) werden dargestellt.
K. CLARKE, W. R. FOX, R. M. SCROWSTON
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Chemistry of Biologically Active Isothiazoles
2007The isothiazole ring as well as the corresponding benzo- and heterocondensed rings are present in many chemically interesting compounds. The isothiazole ring can be a substituent of a bioactive scaffold or the pharmacophore of bioactive molecules. New compounds have been designed, synthesised and tested towards different biological targets and, in many
F. Clerici +3 more
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Tetrahedron, 1970
Abstract N-Alkyl-3-isothiazolones bearing a free 5-position are readily dimerized by base to 2,4-bismethylene-1,3-dithietanes. The dimerization mechanism involves attack by the 5-anion on the SN bond of a second molecule. The action of base on the corresponding N-acyl-3-isothiazolones affords only polymeric material, in a reaction which is evidently
A.W.K. Chan, W.D. Crow, I. Gosney
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Abstract N-Alkyl-3-isothiazolones bearing a free 5-position are readily dimerized by base to 2,4-bismethylene-1,3-dithietanes. The dimerization mechanism involves attack by the 5-anion on the SN bond of a second molecule. The action of base on the corresponding N-acyl-3-isothiazolones affords only polymeric material, in a reaction which is evidently
A.W.K. Chan, W.D. Crow, I. Gosney
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Isothiazoles. Part XI. Carbinols, aryl ketones, and aminomethyl derivatives of isothiazoles
Journal of the Chemical Society C: Organic, 1968Previous work on aryl and hydroxymethyl isothiazoles has been extended and some aroyl isothiazoles and the corresponding secondary alcohols have been prepared. Primary alcohols were obtained by reduction of the known formyl compounds, and secondary alcohols by reactions of Grignard or lithium derivatives with aldehydes.Aroyl derivatives were prepared ...
A. J. Layton, E. Lunt
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Tetrahedron, 1970
Abstract 3-Hydroxyisothiazole exists as the lactim in nonpolar solvents, the lactam form predominating in aqueous solution. Acylation, although extremely rapid in nonpolar solvents, depends on the relative rates of reaction of the two tautomers rather than on their relative proportions.
A.W.K. Chan, W.D. Crow, I. Gosney
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Abstract 3-Hydroxyisothiazole exists as the lactim in nonpolar solvents, the lactam form predominating in aqueous solution. Acylation, although extremely rapid in nonpolar solvents, depends on the relative rates of reaction of the two tautomers rather than on their relative proportions.
A.W.K. Chan, W.D. Crow, I. Gosney
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The vibrational spectrum of isothiazole
Spectrochimica Acta, 1964Abstract The infrared spectrum of isothiazole vapour has been measured between 4000 and 400 cm−1 under high resolution. The assignment of the fundamental modes, based on the rotational envelope of the vapour bands and on the previous assignments for isoxazole and isoxazole-d3 is discussed.
S. Califano, F. Piacenti, G. Sbrana
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