Results 111 to 120 of about 57,431 (346)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Determination of Phenethyl Isothiocyanate, Erucin, Iberverin, and Erucin Nitrile Concentrations in Healthy and Pieris rapae-Infected Broccoli Tissues Using Gas Chromatography-Mass Spectrometry

Chemosensors
Cruciferous vegetables (Brassicaceae family) are a rich source of phytochemicals, in particular glucosinolates (GLS) and their hydrolysis products, isothiocyanates and nitriles.
Irene-Dimitra Mesimeri, Panagiota-Kyriaki Revelou, Violetta Constantinou-Kokotou, Maroula G. Kokotou   +3 more
doaj   +1 more source

Antibacterial activity and mode of action of selected glucosinolate hydrolysis products against bacterial pathogens [PDF]

, 2015
Plants contain numerous components that are important sources of new bioactive molecules with antimicrobial properties. Isothiocyanates (ITCs) are plant secondary metabolites found in cruciferous vegetables that are arising as promising antimicrobial ...
A Aires, A Aires, A Borges, A Borges, A Borges, A Borges, A Conrad, A Rahman, A Sofrata, A Tabata, AA Al-Gendy, AC Abreu, AC Abreu, AD Russell, AD Russell, B Holst, B Janczuk, B Sun, BA Halkier, BA Halkier, BJ McCabe-Sellers, BK Tiwari, C Ferreira, C Jacob, C Wu, CD Grubb, CF Carson, CJ Oss van, CJ Oss van, CJ Oss van, CM Lin, CM Lin, CM Park, E Hong, EFSA, ES Ahn, F Ahimou, F Mushantaf, FB Luciano, FB Luciano, G Barbieri, G Lerebour, G Tegos, H Chen, H Tajima, HJ Busscher, IS Shin, J Heidler, J Palmer, JL Dangl, JW Fahey, K Cejpek, KH Kyung, L Tang, LF D’Antuono, M Cartea, M Jang, M Oussalah, M Saleem, M Simões, M Simões, M Simões, M Simões, MG Kim, MJ Saavedra, MM Cowan, MP Bos, MS Rhee, MT Black, NG Chorianopoulos, P Gilbert, PA Lambert, PJ Delaquis, PS Negi, R Munday, R Troncoso, RA Dixon, RH Kolm, RN Jones, RP Verma, S Ananou, S Burt, S Langsrud, SD Sarker, SG Gómez De Saravia, SY Wang, T Zsolnai, T-T Liu, V Dufour, Y Diab, Y Zhang, Y-H Pang   +91 more
core   +1 more source

Inhibiting plasmid mobility: The effect of isothiocyanates on bacterial conjugation.

International Journal of Antimicrobial Agents, 2019
Bacterial conjugation is the main mechanism for the transfer of multiple antimicrobial resistance genes among pathogenic micro-organisms. This process may be controlled by compounds that inhibit bacterial conjugation.
A. A. Kwapong, P. Stapleton, S. Gibbons
semanticscholar   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Crystal structure of chlorido(η2-phenyl isothiocyanate-κ2C,S)-mer-tris(trimethylphosphane-κP)iridium(I)

Acta Crystallographica Section E, 2014
The molecule of the title compound, [IrCl(C7H5NS)(C3H9P)3], is a distorted octahedral iridium complex with three PMe3 ligands arranged in a meridional geometry, a chloride ion cis to all three PMe3 groups and the phenyl isothiocyanate ligand bonded in an
Joseph S. Merola, Arthur W. Grieb
doaj   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

The rapid generation of isothiocyanates in flow

Beilstein Journal of Organic Chemistry, 2013
Isothiocyanates are versatile starting materials for a wide range of chemical reactions. However, their high nucleophilic susceptibility means they are best prepared and used immediately.
Marcus Baumann, Ian R. Baxendale
doaj   +1 more source

Catechol Derivative‐Based Bioadhesives: Molecular Design for Precision Medical Adhesion

Advanced Science, EarlyView.
This study utilizes tree‐inspired side‐chain engineering to graft five catechol derivatives onto PVA, systematically revealing how side‐chain length and substituents regulate adhesion and cohesion properties. Among them, the PVA‐CA patch demonstrates superior tissue adhesion, biocompatibility, and promotes regeneration, establishing a programmable ...
Xueyu Wang, Zixin Yang, Shan Wang, Weiwei Tan, Zhirui He, Qinyu Duan, Huanan Wang, Tao Chen, Shanshan Hu   +8 more
wiley   +1 more source