Results 131 to 140 of about 13,638 (297)

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions

Advanced Science, EarlyView.
This study uncovers a tri‐directional interplay among cells, hydrogels, and their nascent extracellular matrix. Hydrogel norbornene modification alters CD44‐mediated cell–hydrogel interactions, which shape nascent matrix deposition, composition, and spatial organization.
Joshua Y. Liu, Ziqian Yang, Arina E. Velieva, Eleanor M. Plaster, Mingyue Fan, Donia W. Ahmed, Avinava Roy, Pamela Duran, Pamela Panovich, Alexandra S. Piotrowski‐Daspit, Carlos A. Aguilar, Megan L. Killian, Claudia Loebel   +12 more
wiley   +1 more source

Bioelectrochemically Powered Out‐of‐Equilibrium Hydrogels Enable Feedback‐Regulated Functions

Advanced Science, EarlyView.
A bioelectrochemically powered hydrogel operates far from equilibrium via an antagonistic redox cycle that regulates disulfide exchange within a polyrotaxane network. Coupling electrochemical mediator cycling with enzymatic feedback enables dynamic control of hydrogel mechanics and transport properties, driving glucose‐responsive insulin release with ...
Roberto Baretta, Marco Frasconi
wiley   +1 more source

Evaluation of the nematicidal effect of biodegradable polymer-based granules containing isothiocyanates on Globodera rostochiensis

Siberian Journal of Life Sciences and Agriculture
Background. Golden potato cyst nematode (Globodera rostochiensis, GPCN) is a dangerous quarantine pest of potato, and efficacy of usual nematicides is often limited.
Anna A. Sukhanova, Kristina E. Zabolotnaya, Andrei A. Churakov, Sergei N. Syrtsov, Elena V. Brilkova, Anatoly N. Boyandin   +5 more
doaj   +1 more source

Catalyst- and solvent-free bisphosphinylation of isothiocyanates: a practical method for the synthesis of bisphosphinoylaminomethanes

, 2018
A new protocol for the construction of bisphosphinoylaminomethanes was developed through double addition of phosphine oxides to isothiocyanates.
Ming Li, Li-Rong Wen, Jin-Wei Zhang, Yong-Xu Sun, Wei-Si Guo   +4 more
core   +1 more source

Developing Metal–Polyphenol Network‐Based Single‐Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia

Advanced Science, EarlyView.
Sarcopenia has emerged as a major health challenge in the aging population. Developing a sustained‐release system for whey protein may enhance its effectiveness in mitigating sarcopenia. Herein, a novel “single‐protein particle encapsulation” (SPPE) system is developed to protect whey protein and control its release.
Yafei Zhang, Yuning Zhang, Yongjian Ai, Yao Lu, Heng Quan, Zhen Zhang, Yuqi Wang, Yujia Luo, Xiaoxu Zhang, Yingying Lin, Sijia Song, Huiyuan Guo   +11 more
wiley   +1 more source

Synthesis and Herbicidal Activity of Substituted Pyrazole Isothiocyanates

, 2012
Isothiocyanates and substituted pyrazoles were combined to form a series of novel isothiocyanates with highly effective herbicidal activity. The target compounds were analyzed by elemental analysis, 1H-NMR, EI-MS and IR spectroscopy.
Hua Wu, Jun-Tao Feng, Xing Zhang, Kai-Chun Lin   +3 more
core   +1 more source

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

An ATP7A‐Mediated Endogenous Regulation Bio‐Clay Enzyme Enables Self‐Amplified Copper Accumulation for Immunogenic Pyrop

Advanced Science, EarlyView.
A self‐amplifying bio‐clay nanozyme (Bio‐Clayzyme) disrupts tumor metabolic homeostasis through endogenous copper transporter ATPase (ATP7A) downregulation, enhancing cascade catalysis and triggering immunogenic pyroptosis for effective tumor immunotherapy.
Weimin Xie, Yan Li, Guangyao Li, Ying Chen, Huaming Yang   +4 more
wiley   +1 more source

Mechanistic Profiling of Phenethyl Isothiocyanate in CCRF-CEM Acute Lymphoblastic Leukemia Cells

Pharmaceuticals
Background/Objectives: Phenethyl isothiocyanate (PEITC), a bioactive compound found in cruciferous vegetables, exhibits potent anti-cancer activity, but its molecular mechanisms in acute lymphoblastic leukemia (ALL) remain poorly defined.
Shila Prajapati, Xiao Lei, Mohamed Elbadawi, Mona Dawood, Sabine M. Klauck, Wan Gong, Letian Shan, Percy Kampeis, Thomas Efferth, Xiaohua Lu   +9 more
doaj   +1 more source