Results 221 to 230 of about 20,151 (240)
Reaction of Organic Tin(II) Compound with Phenyl Isothiocyanate and Carbon Disulfide
, 1978 Ikuko Wakeshima +2 more
openalex +1 more source
ChemBioChem, Accepted Article.Naturally occurring isothiocyanates (ITCs) display multiple interesting bioactivities, but their medicinal exploitation is very limited as ITCs are non‐druglike compounds with problematic pharmacokinetic properties. The concept of pseudoglucosinolates (psGSLs) provides a novel prodrug approach for the release of ITCs which can be adjusted to different ...
Aishi Chakrabarti +13 more
wiley +1 more source
ChemistryEurope, EarlyView.Prodrug strategies are used to enhance the pharmacokinetics of small molecule drugs. Here, this approach to rare earth coordination complexes is adopted with applications as diagnostic and therapeutic radiopharmaceuticals: a mono‐ethyl‐phosphonate polyazamacrocyclic chelator for 44Sc and 177Lu reduces blood and bone uptake.
Jennifer N. Whetter +8 more
wiley +1 more source
Recent cutting‐edge technologies for the delivery of peptide nucleic acid.
Chemistry – A European Journal, Accepted Article.Peptide nucleic acids (PNAs) have garnered significant attention due to their enhanced chemical, physical, and binding properties in comparison to natural nucleic acids. This prompted their application in antigene/antisense approach, assigning them a pivotal role in gene editing and, more recently, showing their potential as “bilingual” molecules being
Concetta Avitabile +4 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.5‐Iminothianthrene reacted with various electrophiles, such as acid chlorides, protons, and iso(thio)cyanates, to afford the corresponding adducts. Intramolecular chalcogen bonding (ChB) was identified through natural bond orbital (NBO) analysis based on their X‐ray crystal structures.
Ryutaro Tawara +3 more
wiley +1 more source
ChemMedChem, EarlyView.By N‐methylation, the intramolecular lactam formation in carborane‐substituted diclofenac analogs is prevented, yielding a series of open‐chain derivatives alongside with their phenyl analogs exhibiting anticancer activity and thus offering a promising avenue for future drug development. This study explores the anticancer potential of N‐methylated open‐
Christoph Selg +12 more
wiley +1 more source