Results 1 to 10 of about 24,568 (261)

Synthesis and characterization of selected fused isoxazole and pyrazole derivatives and their antimicrobial activity [PDF]

Journal of the Serbian Chemical Society, 2009
New potent antibacterials, fused isoxazole and pyrazole derivatives, were synthesized using 5,5-dimethylcyclohexane-1,3-dione (1) and 3-[(4-chlorobenzylidene) amino]-2-thioxoimidazolidin-4-one (2) as synthons.
Dabholkar Vijay V., Ansari Faisal Y.
doaj   +7 more sources

Regulating AMPA Receptors with Isoxazole-4-Carboxamide Derivatives: An Electrophysiological Study [PDF]

Journal of Xenobiotics
Isoxazole carboxamide derivatives are intriguing modulators of ionotropic glutamate receptors; more specifically, their prospective analgesic activities based on non-opioid pathways have sparked widespread research.
Mohammad Qneibi, Mohammed Hawash, Sosana Bdir, Mohammad Bdair, Tala Idais, Iyas Sarhan, Joud Touqan   +6 more
doaj   +2 more sources

New Quinazolin-4(3H)-One Derivatives Incorporating Isoxazole Moiety as Antioxidant Agents: Synthesis, Structural Characterization, and Theoretical DFT Mechanistic Study [PDF]

Pharmaceuticals
Background: This research centers on the development and spectroscopic characterization of new quinazolin-4(3H)-one-isoxazole derivatives (5a–e). The aim was to investigate the regioselectivity of the 1,3-dipolar cycloaddition involving arylnitriloxides ...
Yassine Rhazi, Riham Sghyar, Noemi Deak, Bouchra Es-Sounni, Bouchra Rossafi, Albert Soran, Mustapha Laghmari, Azize Arzine, Asmae Nakkabi, Khalil Hammani, Samir Chtita, Mohammed M. Alanazi, Gabriela Nemes, Mohamed El. Yazidi   +13 more
doaj   +2 more sources

tert-Butyl [(4-fluoro-3-isopropoxyisoxazol-5-yl)methyl](phenylsulfonyl)carbamate [PDF]

IUCrData
The title compound, C18H23FN2O6S, a new derivative of a fluoroisoxazole containing sulfonamide functionality has been structurally characterized. The C—S—N—Cipr and C—S—N—Ccarb (ipr = 3-isopropoxyisoxazole, carb = carbamate) torsion angles are 111.1 (3)°
Mohd Abdul Fatah Abdul Manan, David B. Cordes   +1 more
doaj   +2 more sources

Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells [PDF]

Molecules
Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely
Gulim K. Mukusheva, Roza I. Jalmakhanbetova, Altynay Zh. Shaibek, Manshuk S. Nurmaganbetova, Aigerym R. Zhasymbekova, Oralgazy A. Nurkenov, Ekaterina A. Akishina, Irina A. Kolesnik, Evgenij A. Dikusar, Tatiana I. Terpinskaya, Vladimir A. Kulchitsky, Vladimir I. Potkin, Alexander L. Pushkarchuk, Dmitry A. Lyakhov, Dominik L. Michels   +14 more
doaj   +2 more sources

Acridine–Isoxazole and Acridine–Azirine Hybrids: Synthesis, Photochemical Transformations in the UV/Visible Radiation Boundary Region, and Anticancer Activity [PDF]

Molecules
Easy-to-handle N-hydroxyacridinecarbimidoyl chloride hydrochlorides were synthesized as convenient nitrile oxide precursors in the preparation of 3-(acridin-9/2-yl)isoxazole derivatives via 1,3-dipolar cycloaddition with terminal alkynes, 1,1 ...
Ekaterina E. Galenko, Mikhail S. Novikov, Alexander S. Bunev, Alexander F. Khlebnikov   +3 more
doaj   +2 more sources

Phenylisoxazole-3/5-Carbaldehyde Isonicotinylhydrazone Derivatives: Synthesis, Characterization, and Antitubercular Activity

Journal of Chemistry, 2021
Eight new phenylisoxazole isoniazid derivatives, 3-(2′-fluorophenyl)isoxazole-5-carbaldehyde isonicotinylhydrazone (1), 3-(2′-methoxyphenyl)isoxazole-5-carbaldehyde isonicotinylhydrazone (2), 3-(2′-chlorophenyl)isoxazole-5-carbaldehyde ...
Fernando Carrasco, Wilfredo Hernández, Oscar Chupayo, Patricia Sheen, Mirko Zimic, Jorge Coronel, Celedonio M. Álvarez, Sergio Ferrero, Sandra Oramas-Royo, Evgenia Spodine, Jesus M. Rodilla, Juan Z. Dávalos   +11 more
doaj   +1 more source

Synthesis of Spiro Pyrazolone-Oxindole and Bicyclic Pyrazolone Derivatives via Solvent-Dependent Regioselective Aza-1,4/1,6-Michael and Intramolecular Cycloaddition under Catalyst-Free Conditions

SynOpen, 2021
A solvent-dependent, highly regioselective [3+2]-cyclo­addition reaction of isoxazole-styrenes and azomethine imines under catalyst-free conditions is reported, furnishing a library of pyrazolone–spirooxindole hybrids.
Kota Sathish, Sakkani Nagaraju, Dhurke Kashinath   +2 more
doaj   +1 more source

Über Triaryl‐isoxazole [PDF]

Berichte der deutschen chemischen Gesellschaft (A and B Series), 1921
n ...
Meisenheimer, Jakob, Weibezahn, Karl
openaire   +3 more sources

Lewis acid-promoted direct synthesis of isoxazole derivatives

Beilstein Journal of Organic Chemistry, 2023
Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive.
Dengxu Qiu, Chenhui Jiang, Pan Gao, Yu Yuan   +3 more
doaj   +1 more source