Results 1 to 10 of about 17,156 (211)

The Green and Effective Synthesis of Isoxazole-Based Molecules Under Ultrasonic Irradiation Approaches [PDF]

Pharmaceuticals
Isoxazole-based molecules constitute a crucial category of heterocyclic compounds with wide-ranging applications across pharmaceutical development, advanced materials, and pesticide synthesis.
Mei-Tong Chen, Yao-Rong Li, Zhao-Qi Wang, Shan Jiang, Zan-Hui Jia, Da-Wei Zhang   +5 more
doaj   +2 more sources

Synthesis and Structure of Unsymmetrical Anthracenyl-Isoxazole Antitumor Agents Via the Diastereoselective Bromination of 3-(9′-Anthryl)-Isoxazole Esters [PDF]

Crystals
In pursuit of unsymmetrical precursors for the novel series of anthracenyl-isoxazole amide (AIM) antitumor agents, a series of substituted anthracenes were subjected to bromination and re-aromatization in our study, during which we solved four single ...
Michael J. Campbell, Daniel A. Decato, Chun Li, Matthew J. Weaver, Nicholas R. Natale   +4 more
doaj   +2 more sources

Structural Basis for D3/D4-Selective Antagonism of Piperazinylalkyl Pyrazole/Isoxazole Analogs. [PDF]

Molecules
Choi KE, Jang SH, Park WK, No KT, Koh HY, Pae AN, Cho NC.   +6 more
europepmc   +3 more sources

Phenylisoxazole-3/5-Carbaldehyde Isonicotinylhydrazone Derivatives: Synthesis, Characterization, and Antitubercular Activity

Journal of Chemistry, 2021
Eight new phenylisoxazole isoniazid derivatives, 3-(2′-fluorophenyl)isoxazole-5-carbaldehyde isonicotinylhydrazone (1), 3-(2′-methoxyphenyl)isoxazole-5-carbaldehyde isonicotinylhydrazone (2), 3-(2′-chlorophenyl)isoxazole-5-carbaldehyde ...
Fernando Carrasco, Wilfredo Hernández, Oscar Chupayo, Patricia Sheen, Mirko Zimic, Jorge Coronel, Celedonio M. Álvarez, Sergio Ferrero, Sandra Oramas-Royo, Evgenia Spodine, Jesus M. Rodilla, Juan Z. Dávalos   +11 more
doaj   +1 more source

Synthesis of Spiro Pyrazolone-Oxindole and Bicyclic Pyrazolone Derivatives via Solvent-Dependent Regioselective Aza-1,4/1,6-Michael and Intramolecular Cycloaddition under Catalyst-Free Conditions

SynOpen, 2021
A solvent-dependent, highly regioselective [3+2]-cyclo­addition reaction of isoxazole-styrenes and azomethine imines under catalyst-free conditions is reported, furnishing a library of pyrazolone–spirooxindole hybrids.
Kota Sathish, Sakkani Nagaraju, Dhurke Kashinath   +2 more
doaj   +1 more source

Simple Access to Isoxazole-Containing Heterocyclic Hybrids: Isoxazole/Oxazole and Isoxazole/Pyridine

Russian Journal of General Chemistry, 2023
Abstract The synthesis of substituted isoxazole–oxazole hybrids by the noncatalytic reaction of methyl 2-diazo-2-(alkyl/aryl/hetarylisoxazol-5-yl)acetates with alkyl and aryl cyanides has been reported. According to DFT calculations, the reaction proceeds through the intermediate formation of a nitrile ylide and its ...
A. E. Taishev, E. E. Galenko, M. S. Novikov, A. F. Khlebnikov   +3 more
openaire   +1 more source

Design, Synthesis, and Antiproliferative Activity of Benzopyran-4-One-Isoxazole Hybrid Compounds

Molecules, 2023
The biological significance of benzopyran-4-ones as cytotoxic agents against multi-drug resistant cancer cell lines and isoxazoles as anti-inflammatory agents in cellular assays prompted us to design and synthesize their hybrid compounds and explore ...
Shilpi Gupta, Shang Eun Park, Saghar Mozaffari, Bishoy El-Aarag, Keykavous Parang, Rakesh Kumar Tiwari   +5 more
doaj   +1 more source

Design, synthesis, and biological evaluation of phenyl-isoxazole-carboxamide derivatives as anticancer agents

Heterocyclic Communications, 2021
The present study aimed to design and synthesize a series of phenyl-isoxazole-carboxamide derivatives and investigate their antitumor and antioxidant activities. The in vitro cytotoxic evaluation was conducted using the MTS assay against four cancer cell
Hawash Mohammed, Jaradat Nidal, Bawwab Noor, Salem Kamilah, Arafat Hadeel, Hajyousef Yousef, Shtayeh Tahrir, Sobuh Shorooq   +7 more
doaj   +1 more source

Methyl 4-amino-3-methoxyisoxazole-5-carboxylate

IUCrData, 2023
The title compound, C6H8N2O4, a new derivative of isoxazole, has been synthesized and structurally characterized. The crystal structure shows the molecule to be almost planar (r.m.s.
Mohd Abdul Fatah Abdul Manan, David B. Cordes, Alexandra M. Z. Slawin   +2 more
doaj   +1 more source

Novel Isoxazole Derivative Attenuates Ethanol-Induced Gastric Mucosal Injury through Inhibition of H⁺/K⁺-ATPase Pump, Oxidative Stress and Inflammatory Pathways

Molecules, 2022
Isoxazole derivatives are significant enough due to their wide range of pharmacological and therapeutic activities. The purpose of the current study is to use computational, in vitro, in vivo, and extensive molecular approaches to examine the possible ...
Sidra Razzaq, Amber Mahmood Minhas, Neelum Gul Qazi, Humaira Nadeem, Arif-ullah Khan, Fawad Ali, Syed Shams ul Hassan, Simona Bungau   +7 more
doaj   +1 more source