Results 111 to 120 of about 32,281 (298)

Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition

The FEBS Journal, EarlyView.
The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda, Karine Alvarez, Benjamin Morin, Bruno Canard, François Ferron, Nadia Rabah   +5 more
wiley   +1 more source

Fe(II)/Et3N-Relay-catalyzed domino reaction of isoxazoles with imidazolium salts in the synthesis of methyl 4-imidazolylpyrrole-2-carboxylates, its ylide and betaine derivatives

Beilstein Journal of Organic Chemistry, 2015
A simple approach was developed for the synthesis of methyl 4-imidazolylpyrrole-2-carboxylates from easily available compounds, 5-methoxyisoxazoles and phenacylimidazolium salts under hybrid Fe(II)/Et3N relay catalysis.
Ekaterina E. Galenko, Olesya A. Tomashenko, Alexander F. Khlebnikov, Mikhail S. Novikov, Taras L. Panikorovskii   +4 more
doaj   +1 more source

Heroin-piracetam mixture: suggested mechanisms of action and risks of misinterpretation for drug users [PDF]

, 2017
Piracetam is a positive allosteric modulator of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor that has been frequently used in the treatment of cognitive disorders.
Cappelletti, Simone, Ciallella, Costantino, Lombardo, Francesco, Vallone, Giuseppe, Vitale, Pasquale   +4 more
core   +1 more source

Non‐Covalent Molecular Interaction Rules to Define Internal Dimer Coordinates for Quantum Mechanical Potential Energy Scans

Journal of Computational Chemistry, Volume 46, Issue 14, May 30, 2025.
A molecular interaction rules (MIR) workflow for generating potential energy scans of non‐covalent interactions between molecules in well‐defined orientations is presented. This approach allows for systematic investigation of intermolecular interactions across a wide range of functional groups and model chemistries, facilitating the optimization of ...
Suliman Sharif, Anmol Kumar, Alexander D. MacKerell Jr.   +2 more
wiley   +1 more source

Synthesis and Characterization of Some New 1-(3-(heterocyclic-2-yl)-4,5-dihydroisoxazol-5-yl)Pentane-1,2,3,4,5-Pentaol Derivatives from New Chalcone [PDF]

, 2020
The synthesis and characterization of some novel chalcone and isoxazole derivatives has been presented. Isoxazoles (D-F) have been prepared from chalcones (A-C) by treating with hydroxylamine hydrochloride .
Abbas, Abbas F., Al-Assadi, Khansa Abdul Razzaq Ali, Kutafh, Mays Kamil   +2 more
core   +1 more source

The Targets of Deep Brain Stimulation in the Treatment of Treatment‐Resistant Depression: A Review

Brain and Behavior, Volume 15, Issue 5, May 2025.
Schematic Representation of the DBS Procedure for the Management of TRD. The DBS electrode is electrically stimulated by a long lead. Potential mechanisms of action are presented below. The right side highlights the key summary of the article. ABSTRACT Purpose The purpose of this review is to evaluate the current state and potential future directions ...
Jianyang Dong, Mengying Dai, Zinan Guo, Ting Xu, Fangming Li, Jianjun Li   +5 more
wiley   +1 more source

Combined experimental and theoretical studies of regio- and stereoselectivity in reactions of β-isoxazolyl- and β-imidazolyl enamines with nitrile oxides

Beilstein Journal of Organic Chemistry, 2016
Reactions of β-azolyl enamines and nitrile oxides were studied by both experimental and theoretical methods. (E)-β-(4-Nitroimidazol-5-yl), (5-nitroimidazol-4-yl) and isoxazol-5-yl enamines smoothly react regioselectively at room temperature in dioxane ...
Ilya V. Efimov, Marsel Z. Shafikov, Nikolai A. Beliaev, Natalia N. Volkova, Tetyana V. Beryozkina, Wim Dehaen, Zhijin Fan, Viktoria V. Grishko, Gert Lubec, Pavel A. Slepukhin, Vasiliy A. Bakulev   +10 more
doaj   +1 more source

Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity

Molecules, 2018
In this study, a series of novel pyrazole-hydrazone derivatives containing an isoxazole moiety were synthesized. Antiviral bioassays indicated that some of the title compounds exhibited better in vivo antiviral activities against tobacco mosaic virus ...
Zaibo Yang, Pei Li, Xiuhai Gan
semanticscholar   +1 more source

Deficiency of the Synaptic Adhesion Protein Leucine‐Rich Repeat Transmembrane Protein 4 Like 1 Affects Anxiety and Aggression in Zebrafish

Acta Physiologica, Volume 241, Issue 5, May 2025.
ABSTRACT Aim Leucine‐rich repeat transmembrane proteins (LRRTMs) are synaptic adhesion proteins that regulate synapse development and function. They interact transsynaptically with presynaptic binding partners to promote presynaptic differentiation. Polymorphisms of LRRTM4, one of the four members of this protein family, have been linked to multiple ...
Eva Tatzl, Giulia Petracco, Isabella Faimann, Marco Balasso, Agnes Anna Mooslechner, Thomas Bärnthaler, Giovanny Rodriguez‐Blanco, Florian Reichmann   +7 more
wiley   +1 more source

Development of the novel isoxazolo[3,4-d]pyridazinone scaffold, which positively modulates the metabotropic glutamate receptor subtypes 2 and 4 [PDF]

, 2022
The seven transmembrane (7TM) superfamily, also known as G-protein coupled receptors (GPCR), are one of the largest superfamilies in the human genome.
Gates, Christina Ann
core   +1 more source