Results 111 to 120 of about 24,568 (261)

Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits [PDF]

, 2003
The subunits that compose eukaryotic glutamate ion channel receptors have three transmembrane domains (TMs) and terminate with intracellular tails that are important for controlling channel expression and localization.
Colquhoun, D., Schorge, S.
core   +1 more source

ISOXAZOLE – A POTENT PHARMACOPHORE

International Journal of Pharmacy and Pharmaceutical Sciences, 2017
Isoxazole is an azole with an oxygen atom next to the nitrogen. Isoxazole rings are found in some natural products, such as ibotenic acid and also found in a number of drugs, including COX-2 inhibitor valdecoxib. Furoxan, a nitric oxide donor is containing isoxazolyl group & found in many β-lactamase resistant antibiotics, such as cloxacillin ...
S. Raja, Krishna Veni Chikkula
openaire   +3 more sources

Hippocampal‐Specific Insulin Resistance Elicits Synaptic Effects on Glutamate Neurotransmission

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
In animals with hippocampal‐specific insulin resistance, reduced vGluT2 and synaptophysin expression resulted in lowered synaptic glutamate concentrations. These animals also exhibited reduced serine phosphorylation of GluA1 (green postsynaptic receptor) and reduced expression of GluN2B (purple postsynaptic receptor).
Jennifer M. Erichsen, Jennifer L. Woodruff, Claudia A. Grillo, Gerardo G. Piroli, Jim R. Fadel, Lawrence P. Reagan   +5 more
wiley   +1 more source

Benzo-fused Lactams from a Diversity-oriented Synthesis (DOS) Library as Inhibitors of Scavenger Receptor BI (SR-BI)-mediated Lipid Uptake [PDF]

, 2015
We report a new series of 8-membered benzo-fused lactams that inhibit cellular lipid uptake from HDL particles mediated by Scavenger Receptor, Class B, Type I (SR-BI).
Bennion, Melissa, Dandapani, Sivaraman, Dockendorff, Chris, Faloon, Patrick W., Johnston, Stephen, Krieger, Monty, Munoz, Benito, Nieland, Thomas J.F., Palmer, Michelle A., Penman, Marsha, Perez, José R., Pu, Jun, Schreiber, Stuart L., Yu, Miao   +13 more
core   +2 more sources

Acute Effects of Four Major Trace Amines on Zebrafish Behavioral, Neurochemical, and Neuroendocrine Responses

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
A trace amine beta‐phenylethylamine is anxiolytic and reduces brain acetylcholine at 12 μg/L, but elevates anxiety and cortisol levels at 1000 μg/L. Acute tryptamine at 7 mg/L is anxiogenic, reduces shoaling and social interaction, but elevates brain acetylcholine and cortisol levels. Acute tyramine at 15 μg/L, and octopamine at 125, 500, and 1500 μg/L,
Thalia M. Quintanilha, Pietra M. Costa, Ana L. S. Cardoso, Gabrieli S. Battú, Leonardo M. Bastos, Bruno P. dos Santos, Talise E. Müller, Tiago F. de Oliveira, Angelo Piato, Allan V. Kalueff, Murilo S. de Abreu   +10 more
wiley   +1 more source

Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocylces [PDF]

, 2014
Chalcones belong to the flavonoid family which constitutes one of the major classes of naturally occurring oxygen heterocyclic compounds. The alpha,beta-unsaturated carbonyl system of chalcones possesses two electrophilic reactive centers allowing them ...
Albuquerque, Hélio, Cavaleiro, José, Santos, Clementina M.M., Silva, Artur   +3 more
core   +1 more source

Synthetic isoxazole as antiplatelet agent

Platelets, 2013
Abstract Nine synthetic isoxazoles were evaluated as antiplatelet agents and studied the possible mechanism of more active compound. The initial screening was evaluating all compounds against platelet aggregation assays. The most active compound was isoxazole 8 showing an inhibition of platelet aggregation around 70%. In subsequent experiments, ADP and
Gutierrez, Margarita, Amigo, Jessica, Fuentes, Eduardo, Palomo, Ivan, Astudillo, Luis   +4 more
openaire   +5 more sources

Substituent effects in isoxazoles: identification of 4-substituted isoxazoles as Michael acceptors

Journal of the Chemical Society, Perkin Transactions 2, 2002
Crystallographic and theoretical studies have been used to investigate substituent effects, which are manifest in electrochemical and yeast-catalysed reactions of 4- and 5-acyl-, alkoxycarbonyl-, cyano- and phenyl-substituted isoxazoles. The results show that isoxazoles substituted at the 4-position with π-electron-withdrawing substituents have ...
Lee, Connie, Easton, Christopher, Gebara-Coghlan, Mariana, Radom, Leo, Scott, Anthony, Simpson, Gregory Wayne, Willis, Anthony   +6 more
openaire   +2 more sources

CXX.—Action of alkalis on the nitro-compounds of the paraffin series. Part II. Reactions and constitution of methazonic acid and the mode of formation of isoxazoles [PDF]

, 1900
Wyndham R. Dunstan, Ernest Goulding
openalex   +1 more source

Discrimination of Potent Inhibitors of Toxoplasma gondii Enoyl-Acyl Carrier Protein Reductase by a Thermal Shift Assay [PDF]

, 2013
Many microbial pathogens rely on a type II fatty acid synthesis (FASII) pathway that is distinct from the type I pathway found in humans. Enoyl-acyl carrier protein reductase (ENR) is an essential FASII pathway enzyme and the target of a number of ...
Afanador, G.A., Anderson, J.W., Cheng, G., Fidock, D.A., Fishwick, C.W., Fomovska, A., Freire, E., Freundlich, J.S., Jacobus, D.P., Kozikowski, A.P., McLeod, R., McPhillie, M., Muench, S.P., Prigge, S.T., Rice, D.W., Schoen, A., Shieh, H-M., Stec, J., Zhou, Y.   +18 more
core   +1 more source