CNS Neuroscience &Therapeutics, Volume 31, Issue 5, May 2025.To summarize and analyze the general clinical manifestations, laboratory tests, electroencephalography and imaging characteristics, treatment and prognosis of 88 patients with anti‐leucine‐rich glioma inactivated protein 1 antibody encephalitis (LGI1‐AE) at baseline, discharge, and follow‐up in China, aiming to identify risk factors affecting disease ...
Yang Zhao +13 more
wiley +1 more source
Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors [PDF]
, 2016 This work was funded by the Leverhulme Trust (GJF), and the Wellcome Trust (TKS, WT 093228).Neglected tropical diseases caused by parasitic infections are an on-going and increasing concern and burden to human and animal health, having the most ...
Alali +28 more
core +2 more sources
Substituent effects in isoxazoles: identification of 4-substituted isoxazoles as Michael acceptors
Journal of the Chemical Society, Perkin Transactions 2, 2002 Crystallographic and theoretical studies have been used to investigate substituent effects, which are manifest in electrochemical and yeast-catalysed reactions of 4- and 5-acyl-, alkoxycarbonyl-, cyano- and phenyl-substituted isoxazoles. The results show that isoxazoles substituted at the 4-position with π-electron-withdrawing substituents have ...
Lee, Connie +6 more
openaire +2 more sources
Isoxazole-derived amino acids are bromodomain-binding acetyl-lysine mimics: incorporation into histone H4 peptides and histone H3 [PDF]
, 2016 A range of isoxazole-containing amino acids was synthesized, which displace acetyl-lysine-containing peptides from the BAZ2A, BRD4(1), and BRD9 bromodomains.
Conway, Stuart +8 more
core +3 more sources
3-(4-Methoxyphenyl)-5-methylisoxazole-4-carboxylic acid
Acta Crystallographica Section E, 2013 In the title compound, C12H11NO4, the dihedral angle between the benzene and isoxazole rings is 42.52 (8)°. The carboxylic acid group is close to being coplanar with the isoxazole ring [dihedral angle = 5.3 (2)°].
K. Palani +5 more
doaj +1 more source
Синтез та деякі перетворення 5-ізоксазолілсульфонілхлоридів [PDF]
, 2017 The effect of the structure of 5-(benzylthio)isoxazoles on selectivity of the synthesis of 5-(chlorosulfonyl)isoxazoles has been determined. The chemical behavior in relation to amines has been described.Aim. To develop the methods for the synthesis of 5-
Boyko, O. M. +4 more
core +2 more sources
CXX.—Action of alkalis on the nitro-compounds of the paraffin series. Part II. Reactions and constitution of methazonic acid and the mode of formation of isoxazoles [PDF]
, 1900 Wyndham R. Dunstan, Ernest Goulding
openalex +1 more source
Synthetic isoxazole as antiplatelet agent
Platelets, 2013 Abstract Nine synthetic isoxazoles were evaluated as antiplatelet agents and studied the possible mechanism of more active compound. The initial screening was evaluating all compounds against platelet aggregation assays. The most active compound was isoxazole 8 showing an inhibition of platelet aggregation around 70%. In subsequent experiments, ADP and
Gutierrez, Margarita +4 more
openaire +5 more sources
Chemistry Central Journal, 2018 BackgroundDesign and synthesis of new inhibitor agents to deal with pathogenic microorganisms is expanding. In this project, an efficient, environmentally friendly, economical, rapid and mild procedure was developed for the synthesis of novel ...
H. Beyzaei +5 more
semanticscholar +1 more source
Natural products-isoxazole hybrids: A review of developments in medicinal chemistry
Arabian Journal of ChemistryFive-membered heterocycles containing nitrogen, oxygen atoms, especially isoxazoles, are widely present in many natural products and drugs and have relevant medical and pharmaceutical applications.
Jin Wang +3 more
doaj