Results 11 to 20 of about 24,568 (261)

Targeting KRAS in Cancer Therapy: Beyond Inhibitors. [PDF]

MedComm (2020)
MedComm, Volume 6, Issue 7, July 2025.
Chen C, Peng Z, Zhang L.
europepmc   +2 more sources

Co-crystalization and in vitro biological characterization of 5-Aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors [PDF]

, 2012
A potential therapeutic strategy for targeting cancer that has gained much interest is the inhibition of the ATP binding and ATPase activity of the molecular chaperone Hsp90.
Chrisostomos Prodromou, Daumantas Matulis, Egidijus Kazlauskas, Inga Čikotienė, Paul Workman, S. Mark Roe, Swee Y. Sharp, Wenqing Xu   +7 more
core   +5 more sources

Effect of building block transformation in covalent triazine‐based frameworks for enhanced CO2 uptake and metal‐free heterogeneous catalysis [PDF]

, 2020
Invited for the cover of this issue is the group of Pascal Van Der Voort at the University of Ghent and colleagues at Technische Universitat Berlin. The image depicts the covalent triazine frameworks reported in the manuscript for the sorption of CO2 and
Jena, Himanshu, Krishnaraj, Chidharth, Leus, Karen, Schmidt, Johannes, Van Der Voort, Pascal, Van Hecke, Kristof   +5 more
core   +2 more sources

New Approaches for the Synthesis of Heterocyclic Compounds Derived from Cyclohexan-1,3-dione with Anti-proliferative Activities

Acta Chimica Slovenica, 2021
In the present work a series of heterocyclization reactions were adopted using cyclohexan-1,3-dione through its reaction with either furan-2-carbaldehyde or thiophene-2-carbaldehyde to give the corresponding ylidene derivatives 3a,b. The latter compounds
Rafat Milad Mohareb, Yara Raafat Milad, Ayat Ali Masoud   +2 more
doaj   +1 more source

Methyl 4-amino-3-methoxyisoxazole-5-carboxylate

IUCrData, 2023
The title compound, C6H8N2O4, a new derivative of isoxazole, has been synthesized and structurally characterized. The crystal structure shows the molecule to be almost planar (r.m.s.
Mohd Abdul Fatah Abdul Manan, David B. Cordes, Alexandra M. Z. Slawin   +2 more
doaj   +1 more source

Büchwald-Hartwig reaction applied to synthesis of new luminescent liquid crystal triarylamines derived from isoxazoles [PDF]

, 2015
© 2015 Taylor & Francis Group, LLC. The present work describes the synthesis and characterization of novel series of triarylamines isoxazoles (TAA) addressed to the organic photovoltaic materials. Diarylisoxazoles were synthesized by sequential [3+2] 1,
Fernandes, T. H. M., Kelly, S. M., Merlo, A. A., Vilela, G. D.   +3 more
core   +2 more sources

Design, synthesis, and biological evaluation of phenyl-isoxazole-carboxamide derivatives as anticancer agents

Heterocyclic Communications, 2021
The present study aimed to design and synthesize a series of phenyl-isoxazole-carboxamide derivatives and investigate their antitumor and antioxidant activities. The in vitro cytotoxic evaluation was conducted using the MTS assay against four cancer cell
Hawash Mohammed, Jaradat Nidal, Bawwab Noor, Salem Kamilah, Arafat Hadeel, Hajyousef Yousef, Shtayeh Tahrir, Sobuh Shorooq   +7 more
doaj   +1 more source

Isoxazolyl-Derived 1,4-Dihydroazolo[5,1-c][1,2,4]Triazines: Synthesis and Photochemical Properties

Molecules, 2023
New fluorescent dyes containing an assembled 1,4-dihydroazolo[5,1-c][1,2,4]triazine (DAT) core and an isoxazole ring were synthesized through a reaction between diazopyrazole or diazoimidazoles and isoxazolyl-derived enamines in mild conditions.
Elena V. Sadchikova, Nikita E. Safronov, Nikolai A. Beliaev, Valentine G. Nenajdenko, Nataliya P. Belskaya   +4 more
doaj   +1 more source

(3-Methyl-3a,4,7,7a-tetrahydro-5H-4,7-methanoisoxazolo[4,5-d][1,2]oxazin-5-yl)(phenyl)methanone

Acta Crystallographica Section E, 2014
The title compound, C14H14N2O3, is the exo isomer with a syn arrangement of two O atoms in the isoxazole and oxazine rings. The dihedral angle between the isoxazole and phenyl rings is 60.38 (4)°.
Alan J. Lough, Jaipal R. Nagireddy, William Tam   +2 more
doaj   +1 more source

Molecular modeling, synthesis, and antiproliferative evaluation of new isoxazole ring linked by Schiff bases and azo bond

Journal of Advanced Pharmaceutical Technology & Research, 2023
Lung cancer is the most common malignancy worldwide, with approximately 1.8 million new cases yearly. Cytotoxic drugs are frequently used in cancer treatment.
Duha E Taha, Monther F Mahdi, Ayad M. R. Raauf   +2 more
doaj   +1 more source