Results 41 to 50 of about 32,281 (298)
5,8-Dimethoxy-3,9-dimethyl-3a,4,9,9a-tetrahydro-4,9-epoxynaphtho[2,3-d]isoxazole
Acta Crystallographica Section E, 2014 The title compound, C15H17NO4, is the exo isomer with a syn arrangement of the O atom in the isoxazole ring to the methyl group of the bicyclic alkene. The dihedral angle between the isoxazole ring and the benzene ring is 7.42 (9)°.
Alan J. Lough +2 more
doaj +1 more source
Molecules, 2022 Isoxazole derivatives are significant enough due to their wide range of pharmacological and therapeutic activities. The purpose of the current study is to use computational, in vitro, in vivo, and extensive molecular approaches to examine the possible ...
Sidra Razzaq +7 more
doaj +1 more source
Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]
, 2010 L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A. +4 more
core +1 more source
Discovery of Bisamide-heterocycles as Inhibitors of Scavenger Receptor BI (SR-BI)-mediated Lipid Uptake [PDF]
, 2015 A new series of potent inhibitors of cellular lipid uptake from HDL particles mediated by scavenger receptor, class B, type I (SR-BI) was identified. The series was identified via a high-throughput screen of the National Institutes of Health Molecular ...
Bennion, Melissa +14 more
core +2 more sources
Ethyl 5-methyl-3-phenylisoxazole-4-carboxylate
Acta Crystallographica Section E, 2013 In the title compound, C13H13NO3, the dihedral angle between the phenyl and isoxazole rings is 43.40 (13)°. The ethoxycarbonyl group is rotated out of the plane of the isoxazole ring by 16.2 (13)°.
Chandra +4 more
doaj +1 more source
Ligand-biased ensemble receptor docking (LigBEnD): a hybrid ligand/receptor structure-based approach. [PDF]
, 2017 Ligand docking to flexible protein molecules can be efficiently carried out through ensemble docking to multiple protein conformations, either from experimental X-ray structures or from in silico simulations.
Abagyan, Ruben +2 more
core +2 more sources
Scientific Reports, 2020 C-glycosides are important class of molecules exhibit diverse biological activities and present as structural motif in many natural products. Two series of new pyrazoline and isoxazole bridged indole C-glycoside molecular hybrids (n = 36) were ...
P. Kumari +5 more
semanticscholar +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2021 The title compound, C9H7NO2S crystallizes with two independent molecules (A and B) in the asymmetric unit with Z = 8. Both molecules are almost planar with a dihedral angle between the isoxazole and thiophen rings of 3.67 (2)° in molecule A and 10.00 (1)
Rima Laroum +5 more
doaj +1 more source
PAR2 modulators derived from GB88 [PDF]
, 2016 PAR2 antagonists have potential for treating inflammatory, respiratory, gastrointestinal, neurological, and metabolic disorders, but few antagonists are known.
Barry, Grant D. +11 more
core +2 more sources
Target Agnostic Photoaffinity Labelling by Sulfonylhydrazones
Angewandte Chemie, Volume 137, Issue 17, April 17, 2025.Sulfonyl hydrazones were identified as new photo‐crosslinkers exploiting their base catalyzed low‐energy photoactivation that leads to reactive carbenes. The amino acid promiscuity, their usefulness in proteomics application and the range of labelled targets including enzymes, a PPI target and a transcription factor suggests that sulfonyl hydrazones ...
Kristóf Garami +9 more
wiley +2 more sources