Results 51 to 60 of about 17,156 (211)

Methyl 3-phenylisoxazole-5-carboxylate

Acta Crystallographica Section E, 2014
In the title compound, C11H9NO3, the dihedral angle between the isoxazole and phenyl rings is 19.79 (12), while the ester group is inclined to the isoxazole group by 12.14 (6)°.
Li Wang, Ya-jun Li, Yao-dong Li, Wei Zhang, Rui Xu   +4 more
doaj   +1 more source

Synthesis and biological evaluation of (3-arylisoxazol-5-yl) methyl 6-fluoro-4-oxo-4H-chromene-2-carboxylates as antioxidant and antimicrobial agents [PDF]

Journal of the Serbian Chemical Society, 2017
A series of novel (3-aryl-1,2-oxazol-5-yl) methyl 6-fluoro-4-oxo-4H- -chromene-2-carboxylate derivatives (C1-C12) were synthesized by Cu (I) catalyzed reaction of in situ generated nitrile oxides with prop-2-yn-1-yl 6-fluoro-4-oxo-4H-chromene-2 ...
Battula Kumaraswamy, Narsimha Sirassu, Nagavelli Vasudeva Reddy, Srinivasa Rao Mutheneni   +3 more
doaj   +1 more source

Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu, Weiguang Wang, Jian Zhang, Lei Liu, Minpeng Huang, Lei Diao, Shuang Feng, Qiong Yang, Hao Qiu, Bing Pan, Renee A Reijo Pera, Ji Liu, Ninuo Xia, Fang Fang   +13 more
wiley   +1 more source

4-(4-Methoxyphenyl)-3-methyl-1,6-dioxa-2,8-diaza-s-indacen-5(7H)-one

Acta Crystallographica Section E, 2009
In the molecule of the title compound, C16H12N2O4, the pyridine ring is oriented at the same dihedral angle of 2.92 (3)° with respect to the furan and isoxazole rings, while the dihedral angle between furan and isoxazole rings is 1.34 ...
Shu Yan, Xiao-Hong Zhang, Li-Xin Zhang
doaj   +1 more source

Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility

Autism Research, Volume 19, Issue 1, January 2026.
ABSTRACT Auditory hypersensitivity is a prominent symptom in Fragile X syndrome (FXS), the most prevalent monogenic cause of autism and intellectual disability. FXS arises through the loss of the protein encoded by the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene, FMRP, required for normal neural circuit excitability.
Dorit Möhrle, Demi Ma, Wenyue Xue, Jun Yan, Ning Cheng   +4 more
wiley   +1 more source

Research Advances in the Synthesis of α‐ and β‐Damascone: From an Industrial Application Perspective

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Damascone, a precious natural fragrance primarily isolated from rose essential oil, is widely distributed in the flowers, leaves, or essential oils of various aromatic plants such as Rosa damascena, Osmanthus fragrans, Camellia sinensis, and Viola odorata.
Jian Huang, Hua-Chang Wu, Yuheng Yan, Rui Yin, Munmun Bardhan   +4 more
wiley   +1 more source

Synthetic Strategies to Access Fluorinated Azoles

European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber, Mario Djugovski, Tzu‐Yu Huang, Sweta Adhikari, Sudeshna Roy   +4 more
wiley   +1 more source

Synthesis of Novel BINOL Analogs: 3,3′‐Dicarbonyl‐1,1′‐binaphthyl‐4,4′‐diols as Precursors to the Uncharted 5,5′‐Binaphtho[2,1‐d]isoxazole

European Journal of Organic Chemistry, Volume 28, Issue 45, December 10, 2025.
The parent 5,5′‐binaphtho[2,1‐d]isoxazole and its 3,3′‐dimethyl and 3,3′‐diphenyl derivatives are synthesized via condensation of the respective dicarbonyl compounds with hydroxylamine, followed by cyclodehydration of the resulting dioximes. The dicarbonyl precursors are obtained through 4‐ or 6‐step sequences from 1‐naphthol or 1‐naphthaldehyde ...
Marek Surowiec, Ioannis E. Gerontitis, Petros G. Tsoungas, Panteleimon G. Takis, Panagiotis Stathopoulos, Erietta Pouliou, George Varvounis   +6 more
wiley   +1 more source

Crystal structure of (5-chloro-2-hydroxyphenyl)(3-methylisoxazolo[5,4-b]pyridin-5-yl)methanone

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C14H9ClN2O3, the fused pyridine and isoxazole rings are approximately planar, making a dihedral angle of 1.14 (16)°. The molecule is twisted with the benzene ring and the mean plane through the fused pyridine-isoxazole ring system ...
Rajamani Raja, Nataraj Poomathi, Paramasivam T. Perumal, A. SubbiahPandi   +3 more
doaj   +1 more source

Precision Diagnostics in Sports‐Related Traumatic Brain Injury: Pathophysiology, Biomarker Development and Emerging Technologies

Advanced Sensor Research, Volume 4, Issue 12, December 2025.
Sports‐related traumatic brain injuries (TBIs) remain underdiagnosed, within amateur athletic cohorts. This review critically synthesises recent advancements in AI‐assisted neuroimaging, blood‐based biomarker profiling, wearable biosensing platforms for early detection, injury stratification, and longitudinal surveillance of TBIs.
Daniel Nicol, Mohamed T. Patel, Debarati Bhowmik, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source