Results 51 to 60 of about 24,568 (261)

Synthesis and biological evaluation of (3-arylisoxazol-5-yl) methyl 6-fluoro-4-oxo-4H-chromene-2-carboxylates as antioxidant and antimicrobial agents [PDF]

Journal of the Serbian Chemical Society, 2017
A series of novel (3-aryl-1,2-oxazol-5-yl) methyl 6-fluoro-4-oxo-4H- -chromene-2-carboxylate derivatives (C1-C12) were synthesized by Cu (I) catalyzed reaction of in situ generated nitrile oxides with prop-2-yn-1-yl 6-fluoro-4-oxo-4H-chromene-2 ...
Battula Kumaraswamy, Narsimha Sirassu, Nagavelli Vasudeva Reddy, Srinivasa Rao Mutheneni   +3 more
doaj   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation [PDF]

, 2015
1,2,3-Triazole-based heterocycles have previously been shown to possess significant anticancer activity in various tumor models. In the present study, we attached a 1,2,3-triazole moiety to the third position of a 1,2-benzisoxazole heterocycle via copper(
Anusha, S., Ashwini, N., Basappa, ., Bender, A., Fuchs, J.E., Garg, M., Kanojia, D, Koeffler, H.P., Madan, V., Mohan, C.D., Rakesh, K.S., Rangappa, K.S., Rangappa, S., Swaroop, T.R.   +13 more
core   +1 more source

A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor

Molecules, 2021
A convenient synthetic approach to novel functionalized bis(isoxazoles), the promising bivalent ligands of the AMPA receptor, was elaborated.
Dmitry A. Vasilenko, Kirill S. Sadovnikov, Kseniya N. Sedenkova, Dmitry S. Karlov, Eugene V. Radchenko, Yuri K. Grishin, Victor B. Rybakov, Tamara S. Kuznetsova, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Vladimir A. Palyulin, Elena B. Averina   +11 more
doaj   +1 more source

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones [PDF]

, 2010
1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones is described. A series of novel isoxazolines are isolated from the nitrile oxide cycloadditions, whilst the isoxazolines generated from the nitrone cycloadditions ...
Kissane, Marie, Lawrence, Simon E., Maguire, Anita R.   +2 more
core   +1 more source

Supramolecular Aggregates of Amide‐ and Urea‐Functionalized Nanographene

ChemistryEurope, EarlyView.
The effects of amide and urea groups on the morphology, stability, and function of supramolecular NG aggregates are investigated. Amide‐functionalized NG forms stacked aggregates, whereas urea‐functionalized NG forms polymer networks, likely owing to the distinct strengths of the amide–amide and urea–urea NH/O hydrogen bonds.
Haruka Moriguchi, Ryo Sekiya, Takeharu Haino   +2 more
wiley   +1 more source

Synthesis, chemo-informatics, and anticancer evaluation of fluorophenyl-isoxazole derivatives

Open Chemistry, 2021
The current study aimed to design and synthesize a novel series of fluorophenyl-isoxazole-carboxamide derivatives and evaluate their antiproliferative activities.
Hawash Mohammed, Jaradat Nidal, Abualhasan Murad, Amer Johnny, Levent Serkan, Issa Shahd, Ibrahim Sameeha, Ayaseh Aseel, Shtayeh Tahrir, Mousa Ahmed   +9 more
doaj   +1 more source

Synthesis, Physicochemical Characteristics and Plausible Mechanism of Action of an Immunosuppressive Isoxazolo[5,4-e]-1,2,4-Triazepine Derivative (RM33)

Pharmaceuticals, 2021
Previous studies demonstrated strong anti-inflammatory properties of isoxazolo[5,4-e]-1,2,4-triazepine (RM33) in vivo. The aim of this investigation was to describe synthesis, determine physicochemical characteristics, evaluate biological activities in ...
Marcin Mączyński, Andrzej Regiec, Aleksandra Sochacka-Ćwikła, Iwona Kochanowska, Maja Kocięba, Ewa Zaczyńska, Jolanta Artym, Wojciech Kałas, Michał Zimecki   +8 more
doaj   +1 more source

Ligand‐Dependent Chemoselectivity in Gold‐Catalyzed Reactions between Anthranils and Diynamides. Formation of Spiro Azacyclic Compounds versus 1‐Imino‐1H‐Indene‐3‐Carboximidamides

ChemistryEurope, EarlyView.
Gold catalysts direct anthranil/diynamide reactions: PPh3AuCl/AgNTf2 forms spiro azacycles (indole intermediate confirmed), while P(t‐Bu)2(o‐biphenyl)AuCl/AgNTf2 yields indene carboximidamides via a proposed mechanism. Gold‐catalyzed reactions between anthranils and diynamides have been investigated, and their reaction chemoselectivity relies on the ...
Satish Bhausaheb Dawange, Rai‐Shung Liu   +1 more
wiley   +1 more source