Results 91 to 100 of about 20,504 (258)

Kupfer(II)‐photokatalysierte Radikalannellierung von Nitroalkanen mit Alkenen oder Alkinen zur Synthese von Isoxazolinen und Isoxazolen

Angewandte Chemie, Volume 137, Issue 37, September 8, 2025.
Wir stellen ein Cu(II)‐photokatalytisches Verfahren vor, bei dem handelsübliche Nitroalkane für die Synthese von Isoxazolinen und Isoxazolen aus Alkenen bzw. Alkinen verwendet werden. Detaillierte mechanistische Untersuchungen ergaben, dass der breite Substratbereich, der sowohl aktivierte als auch nicht aktivierte Alkene und Alkine umfasst, auf einen ...
Sunaina Sardana, Aryaman Pattanaik, Julia Rehbein, Oliver Reiser   +3 more
wiley   +1 more source

Sintesis de derivados isoxazolil quinolinicos y su actividad biologica [PDF]

, 2009
48 p.Sabidas, son las variadas propiedades que presentan tanto los isoxazoles, como las quinolinas en varios ámbitos hoy en día; Presentan grandes actividades a nivel de antiagregante plaquetario, antifúngicos, inhibidores de enzimas, etc.
Acuna Martinez, Sara, Astudillo Saavedra, Luis (Prof. Guía)   +1 more
core  

Aerosol assisted chemical vapour deposition of transparent conductive aluminum-doped zinc oxide thin films from a zinc triflate precursor [PDF]

, 2016
The use of zinc triflate (trifluoromethanesulfonate), [Zn(OTf)2] as a precursor in the aerosol assisted chemical vapour deposition of zinc oxide thin films is described.
Carmalt, CJ, Knapp, CE, Manzi, JA, Parkin, IP   +3 more
core   +1 more source

Sintesis de isoxazol utilizando ultrasonido, para su posterior cambio estructural en microondas y medicion de actividad biologica [PDF]

, 2010
63 p.Los isoxazoles son una clase de heterociclos, que presentan una gran diversidad de actividades biológicas, dependiendo del sustituyente utilizado, este heterociclo posee una actividad biológica determinada entre las que se puede destacar ...
Astudillo Saavedra, Luis (Prof. Guía), Benavides Bobadilla, Andrea   +1 more
core  

Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria [PDF]

, 2016
Growing evidence suggests persistent mitochondrial permeability transition pore (mPTP) opening is a key pathophysiological event in cell death underlying a variety of diseases.
Briston, T, Duchen, MR, Fukumoto, H, Hartopp, N, Katsumata, R, Koglin, M, Lewis, S, Mistry, K, Powney, B, Roberts, M, Shen, Y, Staddon, JM, Szabadkai, G   +12 more
core   +1 more source

Microtracer‐Based Assessment of the Mass Balance, Pharmacokinetics, and Excretion of [14C]Berzosertib, an Intravenous ATR Inhibitor, in Patients With Advanced Solid Tumors: A Phase 1 Study

Clinical Pharmacology in Drug Development, Volume 14, Issue 9, Page 700-709, September 2025.
Abstract Berzosertib is a small‐molecule ataxia telangiectasia and Rad3‐related protein inhibitor. To assess the clearance mechanism(s) of berzosertib, a Phase 1, 2‐period, open‐label study was conducted in adults with advanced solid tumors who were treated with a single intravenous dose of 210 mg/m2 berzosertib containing approximately 3 µCi of [14C ...
Jayaprakasam Bolleddula, Holger Scheible, Florian Huber, Annick Seithel‐Keuth, Hanno Schieferstein, Deepthi S. Vagge, Nadra Mammasse, Eva Jaks, Jordi Ferrer, Camilo Moulin, Jennifer Dong, Karthik Venkatakrishnan, Zsuzsanna Papai   +12 more
wiley   +1 more source

Palladium-Catalyzed Cascade Annulation/Allylation of Alkynyl Oxime Ethers with Allyl Halides: Rapid Access to Fully Substituted Isoxazoles.

Journal of Organic Chemistry, 2019
A novel and efficient approach for the synthesis of functionalized isoxazoles via palladium-catalyzed cascade annulation/allylation of alkynyl oxime ethers with allyl halides has been established.
Can Li, Jianxiao Li, F. Zhou, Chao-An Li, Wanqing Wu   +4 more
semanticscholar   +1 more source

1,4-addition of TMSCCl3to nitroalkenes: efficient reaction conditions and mechanistic understanding [PDF]

, 2014
Improved synthetic conditions allow preparation of TMSCCl3 in good yield (70 %) and excellent purity. Compounds of the type NBu4X [X=Ph3SiF2 (TBAT), F (tetrabutylammonium fluoride, TBAF), OAc, Cl and Br] act as catalytic promoters for 1,4-additions to a ...
Andrew, Arai, Bamford, Benoit Wahl, Berchadsky, Bujok, Clark, Cunico, Dauzonne, Dietmar, Dilman, Dunoguès, Engelhardt, Fujita, Fujita, Gao, Henegar, Hergott, Kharasch, Kharasch, Kister, Korotaev, Korotaev, Korotaev, Lehmann, Li, Lickiss, Lindup, Liu, Maity, Manna, Na Wu, Namboothiri, Okino, Olah, Pilcher, Pons, Prakash, Shibata, Simon Woodward, Speier, Sun, Takayama, Wakabayashi, William Lewis, Xu, Zhang   +46 more
core   +2 more sources

InCl3-​assisted synthesis and cytotoxic studies of some novel heteroaryl thiazoles [PDF]

, 2013
Heteroaryl thiazoles were synthesized by the Hantzsch reaction of various α-​bromoketones with aryl thioureas using InCl3 as a catalyst in a shorter reaction time. The synthesized compds.
Boggavarapu Chand, S.G., Boregowda Puttaraju, K., Kalegowda Shivashankar, ., Ramamohan Reddy, K., Rasal Vijaykumar, P., Venkata Vivek, P.N.   +5 more
core  

Trilostane in dogs [PDF]

, 2010
Over the last 10 years, trilostane, a competitive inhibitor of steroid synthesis, is being widely used for the treatment of canine hyperadrenocorticism.
Alenza, Angles, Baker, Barker, Bell, Benchekroun, Biller, Boag, Braddock, Cerundolo, Chapman, Clemente, Dewis, Dunn, Eastwood, Feldman, Galac, Galac, Golden, Goy-Thollot, Guptill, Hurley, Ian K. Ramsey, Kenefick, Kintzer, Komanicky, Leone, Lorenz, Machida, Mantis, McGee, McGowan, McGrotty, Neiger, Neiger, Neuman, Peterson, Potts, Puddefoot, Ramsey, Ramsey, Randolph, Reusch, Robinson, Ruckstuhl, Semple, Semple, Sieber-Ruckstuhl, Sieber-Ruckstuhl, Skelly, Tebb, Teshima, Tueni, Vaughan, Wenger, Wilbur, Williams, Winterberg, Witt, Zeugswetter   +59 more
core   +1 more source