Results 111 to 120 of about 19,561 (308)
Synthetic isoxazole as antiplatelet agent
Platelets, 2013 Abstract Nine synthetic isoxazoles were evaluated as antiplatelet agents and studied the possible mechanism of more active compound. The initial screening was evaluating all compounds against platelet aggregation assays. The most active compound was isoxazole 8 showing an inhibition of platelet aggregation around 70%. In subsequent experiments, ADP and
Gutierrez, Margarita +4 more
openaire +5 more sources
Acta Poloniae Pharmaceutica - Drug Research, 2019 : Some new isoxazole derivatives 3a-d were synthesized via the reaction of 3-(dimethylamino)-1-(5- methyl-1-(3-nitrophenyl)-1 H -1,2,3-triazol-4-yl)prop-2-en-1-one ( 1 ) with different hydroximoyl chloride derivatives 2a-d .
Anhar Hassan +3 more
semanticscholar +1 more source
(E)-4-(3-Phenylisoxazol-5-yl)but-3-en-2-one [PDF]
, 2019 (E)-4-(3-Phenylisoxazol-5-yl)but-3-en-2-one was synthesized via the oxidative ring opening reaction of 2-(5-methylfuran-2-yl)-1-phenylethanone oxime, followed by the iodine mediated ...
Kolodina, Alexandra A. +2 more
core +2 more sources
Journal of Computational Chemistry, Volume 46, Issue 14, May 30, 2025.A molecular interaction rules (MIR) workflow for generating potential energy scans of non‐covalent interactions between molecules in well‐defined orientations is presented. This approach allows for systematic investigation of intermolecular interactions across a wide range of functional groups and model chemistries, facilitating the optimization of ...
Suliman Sharif +2 more
wiley +1 more source
SynOpen, 2018 Reaction of enantiopure 3,4-dialkoxy-pyrroline N-oxides with benzyne affords the expected tetrahydrobenzo[d]pyrrolo[1,2-b]isoxazoles along with an unexpected 2,3-disubstitued-N-phenyl-pyrrole derived from an unprecedented rearrangement of the adduct of ...
Franca M. Cordero +3 more
doaj +1 more source
Substituent effects in isoxazoles: identification of 4-substituted isoxazoles as Michael acceptors
Journal of the Chemical Society, Perkin Transactions 2, 2002 Crystallographic and theoretical studies have been used to investigate substituent effects, which are manifest in electrochemical and yeast-catalysed reactions of 4- and 5-acyl-, alkoxycarbonyl-, cyano- and phenyl-substituted isoxazoles. The results show that isoxazoles substituted at the 4-position with π-electron-withdrawing substituents have ...
Lee, Connie +6 more
openaire +2 more sources
CXX.—Action of alkalis on the nitro-compounds of the paraffin series. Part II. Reactions and constitution of methazonic acid and the mode of formation of isoxazoles [PDF]
, 1900 Wyndham R. Dunstan, Ernest Goulding
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Organic Letters, 2018 A novel iminoxyl radical-promoted dichotomous regioselective 5-exo-trig cyclization onto vinylic halogen/1,2-halogen radical shift sequence is developed for the synthesis of halomethyl isoxazoles/cyclic nitrones using β-halo-β,γ- and γ-halo-γ,δ ...
Hong-Lei Chen +5 more
semanticscholar +1 more source
Journal of the Brazilian Chemical Society, 2001 A multilinear-regression analysis using the Kamlet-Abboud-Taft (KAT) solvatochromic parameters in order to elucidate and quantify the solvent effects on the 17O chemical shifts of three 5-trichloromethylisoxazoles [(1a) non-, (1b) 3-methyl- and (1c) 4 ...
Martins Marcos A. P. +7 more
doaj
Chemical Communications, 2018 A new fluorosulfonylation reagent 1-bromoethene-1-sulfonyl fluoride was developed (1-Br-ESF). This unique reagent possesses three addressable handles (vinyl, bromide, and sulfonyl fluoride) and has great potential to function as a tris-electrophile and ...
Jing Leng, Hua-Li Qin
semanticscholar +1 more source