Results 21 to 30 of about 20,504 (258)
Synthesis and Antiprotozoal Profile of 3,4,5‐Trisubstituted Isoxazoles
ChemistryOpen, 2021 A series of 60 4‐aminomethyl 5‐aryl‐3‐substituted isoxazoles were synthesized by an efficient method and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi, protozoa that cause the neglected tropical diseases leishmaniasis and Chagas
Prof. Fernanda Andreia Rosa +9 more
doaj +1 more source
Molecules, 2022 Amides, anhydrides, esters, and thioesters of 2H-azirine-2-carboxylic acids were prepared by a rapid procedure at room temperature involving FeCl2-catalyzed isomerization of 5-chloroisoxazoles to 2H-azirine-2-carbonyl chlorides, followed by reaction with
Anastasiya V. Agafonova +2 more
doaj +1 more source
Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors [PDF]
, 2016 This work was funded by the Leverhulme Trust (GJF), and the Wellcome Trust (TKS, WT 093228).Neglected tropical diseases caused by parasitic infections are an on-going and increasing concern and burden to human and animal health, having the most ...
Alali +28 more
core +2 more sources
Journal of Organic Chemistry, 2020 A continuous flow process is presented that directly converts isoxazoles into their oxazole counterparts via a photochemical transposition reaction.
Cormac Bracken, M. Baumann
semanticscholar +1 more source
Organics, 2021 Conjugated azapolyenes (azabuta-1,3-dienes, aza-/diaza-/oxaza-/oxadiazahexa-1,3,5-trienes) are highly reactive in electrocyclization reactions, which makes them convenient precursors for the synthesis of a wide range of four-, five-, and six-membered ...
Nikolai V. Rostovskii +2 more
doaj +1 more source
Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report [PDF]
, 2015 Mushroom poisonings occur when ingestion of wild mushrooms containing toxins takes place, placing the consumers at life-threatening risk. In the present case report, an unusual multiple poisoning with isoxazoles- and amatoxins-containing mushrooms in a ...
Andrade, Sérgio +10 more
core +1 more source
Isoxazole derivatives as new nitric oxide elicitors in plants
Beilstein Journal of Organic Chemistry, 2017 Several 3,5-disubstituted isoxazoles were obtained in good yields by regiospecific 1,3-dipolar cycloaddition reactions between aromatic nitrile oxides, generated in situ from the corresponding hydroxyimidoyl chlorides, with non-symmetrical activated ...
Anca Oancea +9 more
doaj +1 more source
Ruthenium-catalyzed asymmetric reduction of isoxazolium salts : access to optically active Δ4-isoxazolines [PDF]
, 2018 A tethered MsDPEN–ruthenium catalyst reduces a series of isoxazolium salts, affording optically active Δ4-isoxazolines in moderate to good yields and enantioenrichment. The redundancy of heating or high pressures allowed for chemoselective reduction with
Chew, Renta Jonathan, Wills, Martin
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One-step synthesis of differently bis-functionalized isoxazoles by cycloaddition of carbamoylnitrile oxide with β-keto esters [PDF]
, 2012 A new protocol for synthesizing different functionalized isoxazoles is provided. Carbamoylnitrile oxide generated from nitroisoxazolone underwent inverse electron-demand 1,3-dipolar cycloaddition with 1,3-dicarbonyl compounds in the presence of magnesium
975 +15 more
core +1 more source
, 2020 Isoxazoles and their derivatives represent privileged heteroaromatic motifs, which exhibit remarkable biological and pharmaceutical activities. Notably, metal catalyzed or mediated cyclization/functionalization of alkynes such as alkynone oxime ethers ...
Jianxiao Li +3 more
semanticscholar +1 more source