Results 81 to 90 of about 20,504 (258)
Angewandte Chemie, Volume 137, Issue 41, October 6, 2025.Dieser Review diskutiert mechanochemische Strategien zur späten Modifizierung bioaktiver Wirkstoffe und bietet zugleich eine wertvolle Übersicht zur Auswahl geeigneter Substrate, um das pharmazeutische Potenzial neuer und bestehender (mechano)chemischer Verfahren zu evaluieren.
Johanna Templ, Lars Borchardt
wiley +1 more source
Взаимодействие (2-фторфенил)- и (4фторфенил)-(2-нитрометилциклопентил)метанона с фенилацетиленом [PDF]
, 2015 В результате реакции 1,3-диполярного циклоприсоеднения фенилацетилена и нитрилоксидов, генерируемых из (2-фторфенил)или (4-фторфенил)-(2-нитрометилциклопентил)метанона под действием фенилизоцианата, осуществлен синтез соответствующих изоксазолов и ...
Антоневич, Инесса Петровна +2 more
core
Isoxazole Derivatives as Regulators of Immune Functions
Molecules, 2018 In this review, we present reports on the immunoregulatory properties of isoxazole derivatives classified into several categories, such as immunosuppressive, anti-inflammatory, immunoregulatory, and immunostimulatory compounds.
Michał Zimecki +2 more
doaj +1 more source
Continuous flow chemistry: a discovery tool for new chemical reactivity patterns [PDF]
, 2014 Continuous flow chemistry as a process intensification tool is well known. However, its ability to enable chemists to perform reactions which are not possible in batch is less well studied or understood. Here we present an example, where a new reactivity
Hartwig, Jan +4 more
core +2 more sources
ChemistryOpen, 2019 Anthracenenitrile oxide undergoes 1,3‐dipolar cycloaddition reaction with propargyl bromide affording the expected isoxazole as single regioisomer, suitably synthetically elaborated and functionalized with a protected triple bond.
Dr. Mattia Moiola +7 more
doaj +1 more source
Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity
Advanced Science, Volume 12, Issue 38, October 13, 2025.This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu +8 more
wiley +1 more source
Journal of Organic Chemistry, 2019 A facile synthetic route towards either 3- or 5-fluoroalkyl-substituted isoxazoles or pyrazoles containing an additional functionalization site was developed and applied on a multigram scale.
B. Chalyk +9 more
semanticscholar +1 more source
Calixarene alpha-ketoacetylenes: versatile platforms for reaction with hydrazine nucleophile [PDF]
, 2018 Late stage diversification of calix[4]arenes and thiacalix[4]arenes with heterocycles remains a significant synthetic challenge and hampers further exploitation of the scaffolds.
Acharya +47 more
core +1 more source
Epilepsia Open, Volume 10, Issue 5, Page 1489-1504, October 2025.Abstract Objective The PERPRISE study (Study 509; NCT04202159) was a prospective, observational, non‐interventional study in a real‐world setting in Germany. This study was conducted to evaluate the effectiveness of perampanel as the only adjunctive treatment for 12 months in patients aged ≥18 years with focal to bilateral tonic–clonic seizures (FBTCS)
Bernhard J. Steinhoff +3 more
wiley +1 more source
Synthesis and Antimicrobial Evaluation of Some Heterocyclic Chalcone Derivatives
Molecules, 2011 Some new heterocyclic compounds containing isoxazole, pyrazole and oxadiazole ring systems were prepared from various chalcones. The synthesized compounds have been characterized by elemental analysis and spectral methods.
Essam Mohamed Sharshira +1 more
doaj +1 more source