Results 81 to 90 of about 20,875 (302)

Взаимодействие (2-фторфенил)- и (4фторфенил)-(2-нитрометилциклопентил)метанона с фенилацетиленом [PDF]

, 2015
В результате реакции 1,3-диполярного циклоприсоеднения фенилацетилена и нитрилоксидов, генерируемых из (2-фторфенил)или (4-фторфенил)-(2-нитрометилциклопентил)метанона под действием фенилизоцианата, осуществлен синтез соответствующих изоксазолов и ...
Антоневич, Инесса Петровна, Каток, Ядвига Марьяновна, Нестерова, Светлана Владимировна   +2 more
core  

Continuous flow chemistry: a discovery tool for new chemical reactivity patterns [PDF]

, 2014
Continuous flow chemistry as a process intensification tool is well known. However, its ability to enable chemists to perform reactions which are not possible in batch is less well studied or understood. Here we present an example, where a new reactivity
Hartwig, Jan, Kirschning, Andreas, Ley, Steven V., Metternich, Jan B., Nikbin, Nikzad   +4 more
core   +2 more sources

Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility

Autism Research, Volume 19, Issue 1, January 2026.
ABSTRACT Auditory hypersensitivity is a prominent symptom in Fragile X syndrome (FXS), the most prevalent monogenic cause of autism and intellectual disability. FXS arises through the loss of the protein encoded by the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene, FMRP, required for normal neural circuit excitability.
Dorit Möhrle, Demi Ma, Wenyue Xue, Jun Yan, Ning Cheng   +4 more
wiley   +1 more source

Acridine–Isoxazole and Acridine–Azirine Hybrids: Synthesis, Photochemical Transformations in the UV/Visible Radiation Boundary Region, and Anticancer Activity

Molecules
Easy-to-handle N-hydroxyacridinecarbimidoyl chloride hydrochlorides were synthesized as convenient nitrile oxide precursors in the preparation of 3-(acridin-9/2-yl)isoxazole derivatives via 1,3-dipolar cycloaddition with terminal alkynes, 1,1 ...
Ekaterina E. Galenko, Mikhail S. Novikov, Alexander S. Bunev, Alexander F. Khlebnikov   +3 more
doaj   +1 more source

Regioselective synthesis of heterocyclic N-sulfonyl amidines from heteroaromatic thioamides and sulfonyl azides

Beilstein Journal of Organic Chemistry, 2020
N-Sulfonyl amidines bearing 1,2,3-triazole, isoxazole, thiazole and pyridine substituents were successfully prepared for the first time by reactions of primary, secondary and tertiary heterocyclic thioamides with alkyl- and arylsulfonyl azides.
Vladimir Ilkin, Vera Berseneva, Tetyana Beryozkina, Tatiana Glukhareva, Lidia Dianova, Wim Dehaen, Eugenia Seliverstova, Vasiliy Bakulev   +7 more
doaj   +1 more source

Calixarene alpha-ketoacetylenes: versatile platforms for reaction with hydrazine nucleophile [PDF]

, 2018
Late stage diversification of calix[4]arenes and thiacalix[4]arenes with heterocycles remains a significant synthetic challenge and hampers further exploitation of the scaffolds.
Acharya, Bi, Bistri, Boersch, Bromidge, Burilov, Burilov, Cecioni, Chen, Creaven, Credi, Epifanova, Fasting, Gotzinger, Grandjean, Gutsche, Iwamoto, Karpov, Kim, Kumar, Kumar, Lamouchi, Lavendomme, Maher, Muravev, Muravev, Muravev, Muravev, Muravev, Muravev, Ovsyannikov, Rad, Roy, Savithri, Shen, Solovieva, Solovieva, Song, Takahashi, Thiabaud, Vasilevsky, Vicens, Wang, Wang, Wang, Wang, Yang, Yin   +47 more
core   +1 more source

Research Advances in the Synthesis of α‐ and β‐Damascone: From an Industrial Application Perspective

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Damascone, a precious natural fragrance primarily isolated from rose essential oil, is widely distributed in the flowers, leaves, or essential oils of various aromatic plants such as Rosa damascena, Osmanthus fragrans, Camellia sinensis, and Viola odorata.
Jian Huang, Hua-Chang Wu, Yuheng Yan, Rui Yin, Munmun Bardhan   +4 more
wiley   +1 more source

Isoxazole Derivatives as Regulators of Immune Functions

Molecules, 2018
In this review, we present reports on the immunoregulatory properties of isoxazole derivatives classified into several categories, such as immunosuppressive, anti-inflammatory, immunoregulatory, and immunostimulatory compounds.
Michał Zimecki, Urszula Bąchor, Marcin Mączyński   +2 more
doaj   +1 more source

Fluorescent Probes from Aromatic Polycyclic Nitrile Oxides: Isoxazoles versus Dihydro‐1λ3,3,2λ4‐Oxazaborinines

ChemistryOpen, 2019
Anthracenenitrile oxide undergoes 1,3‐dipolar cycloaddition reaction with propargyl bromide affording the expected isoxazole as single regioisomer, suitably synthetically elaborated and functionalized with a protected triple bond.
Dr. Mattia Moiola, Dr. Antonio Bova, Dr. Stefano Crespi, Dr. Misal G. Memeo, Prof. Mariella Mella, Prof. Herman S. Overkleeft, Dr. Bogdan I. Florea, Prof. Paolo Quadrelli   +7 more
doaj   +1 more source

Synthesis of Novel BINOL Analogs: 3,3′‐Dicarbonyl‐1,1′‐binaphthyl‐4,4′‐diols as Precursors to the Uncharted 5,5′‐Binaphtho[2,1‐d]isoxazole

European Journal of Organic Chemistry, Volume 28, Issue 45, December 10, 2025.
The parent 5,5′‐binaphtho[2,1‐d]isoxazole and its 3,3′‐dimethyl and 3,3′‐diphenyl derivatives are synthesized via condensation of the respective dicarbonyl compounds with hydroxylamine, followed by cyclodehydration of the resulting dioximes. The dicarbonyl precursors are obtained through 4‐ or 6‐step sequences from 1‐naphthol or 1‐naphthaldehyde ...
Marek Surowiec, Ioannis E. Gerontitis, Petros G. Tsoungas, Panteleimon G. Takis, Panagiotis Stathopoulos, Erietta Pouliou, George Varvounis   +6 more
wiley   +1 more source