Results 11 to 20 of about 5,382 (243)

A Comprehensive Study of the Synthesis, Spectral Characteristics, Quantum–Chemical Molecular Electron Density Theory, and In Silico Future Perspective of Novel CBr₃-Functionalyzed Nitro-2-Isoxazolines Obtained via (3 + 2) Cycloaddition of (E)-3,3,3-Tribromo-1-Nitroprop-1-ene [PDF]

Molecules
The search for new heterocyclic compounds with biological potential is one of the current challenges in modern chemistry. Therefore, the comprehensive study of (3 + 2) cycloaddition (32CA) reactions between a series of aryl-substituted nitrile N-oxides ...
Karolina Zawadzińska-Wrochniak, Karolina Kula, Mar Ríos-Gutiérrez, Bartłomiej Gostyński, Tomasz Krawczyk, Radomir Jasiński   +5 more
doaj   +2 more sources

The mosquitocidal activity of isoxazoline derivatives afoxolaner, lotilaner, and fluralaner are not affected by mosquito sugar or antibiotic treatment [PDF]

Scientific Reports
Long-lasting insecticidal nets and indoor residual sprays have played a major role in significantly reducing the burden of malaria. However, the management of mosquitoes resistant to current insecticides continues to be challenging.
Harouna Soré, Wamdaogo Moussa Guelbeogo, Soumanaba Zongo, Judith M. Bolscher, Nicolas Ouédraogo, Adama Gansané, Teun Bousema, Katharine A. Collins, Koen J. Dechering   +8 more
doaj   +3 more sources

Effectiveness of lotilaner on furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae) [PDF]

Revista Brasileira de Parasitologia Veterinária
An evaluation was made of the larvicidal efficacy of lotilaner (Credeli®) in the treatment of dogs naturally infested with Dermatobia hominis larvae. A total of 12 dogs presenting at least three live D. hominis larvae were medicated.
Rafaella Tortoriello, Luisa Xavier Christ, Victoria Caroline de Almeida Marques, Bruna Sampaio Martins, Julio Israel Fernandes   +4 more
doaj   +2 more sources

Energetic Aspects and Molecular Mechanism of 3-Nitro-substituted 2-Isoxazolines Formation via Nitrile N-Oxide [3+2] Cycloaddition: An MEDT Computational Study [PDF]

Molecules
Regioselectivity and the molecular mechanism of the [3+2] cycloaddition reaction between nitro-substituted formonitrile N-oxide 1 and electron-rich alkenes were explored on the basis of the wb97xd/6-311+G(d) (PCM) quantum chemical calculations.
Ewa Dresler, Aneta Wróblewska, Radomir Jasiński   +2 more
doaj   +2 more sources

Copper(II)-Photocatalyzed Radical Anellation of Nitroalkanes with Alkenes or Alkynes for the Synthesis of Isoxazolines and Isoxazoles. [PDF]

Angew Chem Int Ed Engl
We present a Cu(II)‐photocatalyzed method that employs commercially available nitroalkanes for the synthesis of isoxazolines and isoxazoles from alkenes and alkynes, respectively. Detailed mechanistic investigations revealed that the broad substrate scope, encompassing both activated and unactivated alkenes and alkynes, is attributable to a radical ...
Sardana S, Pattanaik A, Rehbein J, Reiser O.   +3 more
europepmc   +2 more sources

Synthesis and Application of Bioactive N-Functionalized Aziridines. [PDF]

Angew Chem Int Ed Engl
This review discusses modern synthetic methods for the preparation of aziridine‐containing small molecules, including biocatalytic, electrocatalytic, and photocatalytic strategies. We highlight the compatibility of various synthetic methods with control of the exocyclic N‐substituent.
Tan H, Samanta S, Qiu N, Adibekian A, Powers DC.   +4 more
europepmc   +3 more sources

in silico Study Reveals Potential Docking Sites of δ 2-isoxazolines derivates for Inhibiting Russell’s Viper PLA2 Toxin [PDF]

Journal of Tropical Life Science, 2021
Snake venom phospholipase A2s (svPLA2s) has been known as the most abundant component and predominant cause of Russell’s viper envenomation. Limitation to serum therapy and considerable pharmacological interest led the researcher to syn-thesized multi ...
Tsaniyah Nur Kholilah, Widodo, Nia Kurniawan   +2 more
doaj   +1 more source

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Pharmaceuticals, 2023
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates.
Xiyue Wang, Qingyun Hu, Hui Tang, Xinhui Pan   +3 more
doaj   +1 more source

Efficacy of Oral Sarolaner for the Treatment of Feline Otodectic Mange

Pathogens, 2021
Otodectes cynotis is a mite with a cosmopolitan distribution that is the primary agent for the development of otitis externa in feline species. The aim of this study was to evaluate the efficacy of the oral administration of sarolaner for the treatment ...
Diefrey Ribeiro Campos, Jéssica Karoline de Oliveira Chaves, Brena Gava Guimarães, So Yin Nak, Gabriela Pereira Salça de Almeida, Isabela Scalioni Gijsen, Juliana de Moraes Intrieri, Fabio Barbour Scott   +7 more
doaj   +1 more source

3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles

Molecules, 2021
In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various α-nitroketones using chloramine-T as the base. The scope of α-nitroketones and alkenes is extensive, including different alkenes and alkynes to form various ...
Xinhui Pan, Xiaobing Xin, Ying Mao, Xin Li, Yanan Zhao, Yidi Liu, Ke Zhang, Xiaoda Yang, Jinhui Wang   +8 more
doaj   +1 more source