Results 11 to 20 of about 8,940 (287)

An unexpected transformation by reduction of isoxazolines [PDF]

Comptes Rendus. Chimie, 2012
Abstract Aromatic nitrile oxides undergo regio- and stereo-specific 1,3-dipolar cycloaddition reactions with racemic 5-hydroxy-4-methyl-1,5-dihydropyrrol-2-one derivatives 1 . In each case, a single product 3 results from an anti approach to the hydroxyl group, the oxygen of the 1,3-dipole being attached to C-5 of pyrrolidinones.
Naoufel Ben Hamadi, Moncef Msaddek
openalex   +3 more sources

Effective treatment with afoxolaner (NexGard) of Trixacarus caviae in a pet guinea pig [PDF]

Veterinary Medicine and Science
Trixacarus caviae is a sarcoptic mange mite infesting guinea pigs. Infestation in immunosuppressed animals produces severe dermatological problems, including alopecia, intense pruritus, hyperkeratosis and non‐dermatological issues (e.g., seizures ...
Georgiana Deak, Miruna‐Maria Matei, Anca‐Alexandra Doboși, Aura Livia Ursache, Andrada Negoescu, Marian Taulescu   +5 more
doaj   +2 more sources

Ruthenium-catalyzed asymmetric reduction of isoxazolium salts : access to optically active Δ4-isoxazolines [PDF]

Journal of Organic Chemistry, 2018
A tethered MsDPEN–ruthenium catalyst reduces a series of isoxazolium salts, affording optically active Δ4-isoxazolines in moderate to good yields and enantioenrichment. The redundancy of heating or high pressures allowed for chemoselective reduction with
Chew, Renta Jonathan, Wills, Martin
core   +2 more sources

The mosquitocidal activity of isoxazoline derivatives afoxolaner, lotilaner, and fluralaner are not affected by mosquito sugar or antibiotic treatment [PDF]

Scientific Reports
Long-lasting insecticidal nets and indoor residual sprays have played a major role in significantly reducing the burden of malaria. However, the management of mosquitoes resistant to current insecticides continues to be challenging.
Harouna Soré, Wamdaogo Moussa Guelbeogo, Soumanaba Zongo, Judith M. Bolscher, Nicolas Ouédraogo, Adama Gansané, Teun Bousema, Katharine A. Collins, Koen J. Dechering   +8 more
doaj   +3 more sources

A Comprehensive Study of the Synthesis, Spectral Characteristics, Quantum–Chemical Molecular Electron Density Theory, and In Silico Future Perspective of Novel CBr₃-Functionalyzed Nitro-2-Isoxazolines Obtained via (3 + 2) Cycloaddition of (E)-3,3,3-Tribromo-1-Nitroprop-1-ene [PDF]

Molecules
The search for new heterocyclic compounds with biological potential is one of the current challenges in modern chemistry. Therefore, the comprehensive study of (3 + 2) cycloaddition (32CA) reactions between a series of aryl-substituted nitrile N-oxides ...
Karolina Zawadzińska-Wrochniak, Karolina Kula, Mar Ríos-Gutiérrez, Bartłomiej Gostyński, Tomasz Krawczyk, Radomir Jasiński   +5 more
doaj   +2 more sources

Effectiveness of lotilaner on furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae) [PDF]

Revista Brasileira de Parasitologia Veterinária
An evaluation was made of the larvicidal efficacy of lotilaner (Credeli®) in the treatment of dogs naturally infested with Dermatobia hominis larvae. A total of 12 dogs presenting at least three live D. hominis larvae were medicated.
Rafaella Tortoriello, Luisa Xavier Christ, Victoria Caroline de Almeida Marques, Bruna Sampaio Martins, Julio Israel Fernandes   +4 more
doaj   +2 more sources

Energetic Aspects and Molecular Mechanism of 3-Nitro-substituted 2-Isoxazolines Formation via Nitrile N-Oxide [3+2] Cycloaddition: An MEDT Computational Study [PDF]

Molecules
Regioselectivity and the molecular mechanism of the [3+2] cycloaddition reaction between nitro-substituted formonitrile N-oxide 1 and electron-rich alkenes were explored on the basis of the wb97xd/6-311+G(d) (PCM) quantum chemical calculations.
Ewa Dresler, Aneta Wróblewska, Radomir Jasiński   +2 more
doaj   +2 more sources

Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents

RSC Advances, 2020
Electrophilic fluorine-mediated dearomative spirocyclization has been developed to synthesize a range of fluoro-substituted spiro-isoxazoline ethers and lactones. The in vitro biological assays of synthesized compounds were probed for anti-viral activity
Prasanta Das, Sarah Boone, Dipanwita Mitra, Lindsay Turner, Ritesh Tandon, Dražen Raucher, Ashton T. Hamme   +6 more
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Syntheses of Isoxazoline-Based Amino Acids by Cycloaddition of Nitrile Oxides and Their Conversion into Highly Functionalized Bioactive Amino Acid Derivatives [PDF]

, 2012
The present account illustrates the syntheses of isoxazoline- based amino acids by the cycloaddition of 1,3-dipolar nitrile oxides to the C–C double bond of unsaturated amino acid derivatives, with focus on the regio- and stereoselectivities of the ...
F. Fülöp, Lóránd Kiss, Melinda Nonn
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Copper(II)-Photocatalyzed Radical Anellation of Nitroalkanes with Alkenes or Alkynes for the Synthesis of Isoxazolines and Isoxazoles. [PDF]

Angew Chem Int Ed Engl
We present a Cu(II)‐photocatalyzed method that employs commercially available nitroalkanes for the synthesis of isoxazolines and isoxazoles from alkenes and alkynes, respectively. Detailed mechanistic investigations revealed that the broad substrate scope, encompassing both activated and unactivated alkenes and alkynes, is attributable to a radical ...
Sardana S, Pattanaik A, Rehbein J, Reiser O.   +3 more
europepmc   +2 more sources