Results 31 to 40 of about 2,910 (203)

Differential Impact of Ergosterol on Yeast Membranes Exposed to Membrane-Targeting Antimicrobial Compounds. [PDF]

Chembiochem
Biomimetic membranes (liposomes) were prepared from yeast phospholipids with variable concentrations of ergosterol and exposed to antimicrobial compounds. Dynamic and electrophoretic light scattering measured changes in size and ζ‐potential to study their interaction with the antimicrobial compounds.
Villacres JI, Shaikhet M, Avis TJ.
europepmc   +2 more sources

Characterization of iturin synthetase in the wild-typeBacillus subtilisstrain producing iturin and in an iturin deficient mutant [PDF]

FEMS Microbiology Letters, 1996
Françoise Besson, Georges Michel
exaly   +2 more sources

Synthesis of Trifluoromethylated Analogues of the Cyclic Lipopeptide Iturin A and Evaluation of their Antifungal Activity. [PDF]

Chempluschem
Iturin A is an antifungal lipopeptide with broad applications. Here, we present a novel synthesis and semisynthesis of trifluoromethylated iturin A analogues. Their antifungal activity was evaluated against Fusarium graminearum and Candida albicans.
Karamanis P, Kiernan M, Muldoon J, Evans P, Murphy CD, Rubini M.   +5 more
europepmc   +2 more sources

Enhanced production of iturin A by strengthening fatty acid synthesis modules in Bacillus amyloliquefaciens

Frontiers in Bioengineering and Biotechnology, 2022
Iturin A is a biosurfactant with various applications, and its low synthesis capability limits its production and application development. Fatty acids play a critical role in cellular metabolism and target product syntheses, and the relationship between ...
Lin Gao, Lin Gao, Menglin She, Jiao Shi, Dongbo Cai, Dong Wang, Min Xiong, Guoming Shen, Jiaming Gao, Min Zhang, Zhifan Yang, Shouwen Chen, Shouwen Chen   +12 more
doaj   +1 more source

Effects of Bacillus subtilis iturin A on HepG2 cells in vitro and vivo

AMB Express, 2021
Iturin A with cyclic peptide and fatty acid chain isolated from Bacillus subtilis fermentation shows a variety of biological activities. Among them, the anticancer activity attracted much attention.
Haobin Zhao, Lu Yan, Ling Guo, Hui Sun, Qingsheng Huang, Dongyan Shao, Chunmei Jiang, Junling Shi   +7 more
doaj   +1 more source

Phylogenetic Distribution of Secondary Metabolites in the Bacillus subtilis Species Complex

mSystems, 2021
Microbes produce a plethora of secondary (or specialized) metabolites that, although not essential for primary metabolism, benefit them to survive in the environment, communicate, and influence cell differentiation.
Kat Steinke, Omkar S. Mohite, Tilmann Weber, Ákos T. Kovács   +3 more
doaj   +3 more sources

Functional Implications of Marine Biosurfactants and Their Therapeutic Potential Against Alzheimer's Disease. [PDF]

Food Sci Nutr
Marine‐derived biosurfactants produced by microorganisms (including bacteria, fungi, and yeast) have amphiphilic properties that facilitate membrane interactions and transport across the blood–brain barrier (BBB). These biosurfactants exhibit neuroprotective activity by targeting mechanisms implicated in Alzheimer's disease, including reducing ...
Irfan Z, Prusty SK, Giri S, Nandi A, Gouda M.   +4 more
europepmc   +2 more sources

Characterization of iturin synthetase in the wild-typeBacillus subtilisstrain producing iturin and in an iturin deficient mutant [PDF]

FEMS Microbiology Letters, 1996
The multi-enzyme system responsible for the biosynthesis of iturin, an antifungal lipopeptide of Bacillus subtilis, was partially purified by chromatography on different affigels. In the wild-type strain, two subunits of the iturin synthetase (ITs and ITagp) were characterized: ITs activated only L-Ser, one of the iturin amino acid components, and ...
C, Feignier, F, Besson, G, Michel
openaire   +2 more sources

ACR3 as a Key Regulator Antimicrobial Lipopeptide Synthesis and Efflux in Bacillus velezensis HN-1. [PDF]

Mol Plant Pathol
Lipopeptides are natural antibiotics produced by Bacillus velezensis. Mutation of acr3 led to the complete loss of antimicrobial activity. Following the biological assays for validation, we found ACR3 protein may serve as a master switch of lipopeptides synthesis regulation, and control transmembrane transport of lipopeptides by the ABC pathway ...
Shen Y, Wang J, Zeng R, Wang H, Fang Y, Lin Z, Wang Y, Liu W, Xie Q, Jin P, Miao W.   +10 more
europepmc   +2 more sources

Cloning, Sequencing, and Characterization of the Iturin A Operon [PDF]

Journal of Bacteriology, 2001
ABSTRACT Bacillus subtilis RB14 is a producer of the antifungal lipopeptide iturin A. Using a transposon, we identified and cloned the iturin A synthetase operon of RB14, and the sequence of this operon was also determined.
K, Tsuge, T, Akiyama, M, Shoda
openaire   +5 more sources