Results 1 to 10 of about 709 (88)

Do passive range of motion exercises lead to quicker postsurgical recovery of canine IVDD?

Veterinary Evidence, 2023
PICO Question In canine patients recovering from surgery for intervertebral disc disease, do passive range of motion exercises, compared to no intervention, lead to a shorter or faster rate of recovery?
Alexander Wallace
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Necroptosis of nucleus pulposus cells involved in intervertebral disc degeneration through MyD88 signaling

Frontiers in Endocrinology, 2022
Background contextLow back pain, affecting nearly 40% of adults, mainly results from intervertebral disc degeneration (IVDD), while the pathogenesis of IVDD is still not fully elucidated.
Hong Fan, Hong Fan, Zhe Chen, Hai-Bin Tang, Le-Qun Shan, Zi-Yi Chen, Shi-Chang Liu, Yong-Yuan Zhang, Xin-Yu Guo, Hao Yang, Ding-Jun Hao   +10 more
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Visfatin promotes intervertebral disc degeneration by inducing IL-6 expression through the ERK/JNK/p38 signalling pathways

Adipocyte, 2021
Visfatin reportedly induces the expression of proinflammatory cytokines. Severe grades of intervertebral disc disease (IVDD) exhibit higher expression of visfatin than mild ones.
Haitao Cui, Xianfa Du, Caijun Liu, Shunlun Chen, Haowen Cui, Hui Liu, Jianru Wang, Zhaomin Zheng   +7 more
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Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects

Journal of Orthopaedic Translation, 2023
Background: The incidence of intervertebral disc degeneration (IVDD) is a common degenerative disease with inflammation, decreased autophagy, and progression of fibrosis as its possible pathogenesis.
Rui Lu, Haoran Xu, Xiaofeng Deng, Yingguang Wang, Zhiyi He, Shimeng Xu, Shuang Liang, Xiaojian Huang, Hongbo You, Fengjing Guo, Peng Cheng, An-min Chen   +11 more
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Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth

Scientific Reports, 2021
Aberrant mechanical factor is one of the etiologies of the intervertebral disc (IVD) degeneration (IVDD). However, the exact molecular mechanism of spinal mechanical loading stress-induced IVDD has yet to be elucidated due to a lack of an ideal and ...
Fangda Fu, Ronghua Bao, Sai Yao, Chengcong Zhou, Huan Luo, Zhiguo Zhang, Huihao Zhang, Yan Li, Shuxin Yan, Huan Yu, Weibin Du, Yanping Yang, Hongting Jin, Peijian Tong, Zhi-tao Sun, Ming Yue, Di Chen, Chengliang Wu, Hongfeng Ruan   +18 more
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Recurrence rate of intervertebral disc disease in surgically treated French Bulldogs: a retrospective study (2009–2019)

Acta Veterinaria Scandinavica, 2023
Background Intervertebral disc disease (IVDD) is a common diagnosis and well-investigated pathological condition in French Bulldogs with neurological deficiencies.
Dominique Leu, Beatriz Vidondo, Veronika Stein, Franck Forterre   +3 more
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Distinctive roles of tumor necrosis factor receptor type 1 and type 2 in a mouse disc degeneration model

Journal of Orthopaedic Translation, 2021
Background: Elevated tumor necrosis factor alpha (TNF-α) expression is correlated with the progression of intervertebral disc degeneration (IVDD). Progranulin binding to tumor necrosis factor receptor (TNFR) and its derivative Atsttrin are effective for ...
Shanzheng Wang, Guodong Sun, Pan Fan, Lei Huang, Yaofei Chen, Changhong Chen   +5 more
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Icariin regulates stem cell migration for endogenous repair of intervertebral disc degeneration by increasing the expression of chemotactic cytokines

BMC Complementary Medicine and Therapies, 2022
Background Icariin (ICA) can promote the migration and bone formation of bone marrow mesenchymal stem cells. This study explored a potential role of ICA in recruiting stem cell niches (SCNs) within the intervertebral disc region (ISN)-derived stem cells (
Zhaofei Zhang, Fengwei Qin, Yonghui Feng, Sineng Zhang, Chunliang Xie, He Huang, Chaohui Sang, Shaoyu Hu, Feng Jiao, Jie Jiang, Yi Qin   +10 more
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Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration

Frontiers in Bioengineering and Biotechnology, 2022
Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP ...
Yuhao Wu, Yuhao Wu, Shiwei Shen, Shiwei Shen, Yifeng Shi, Yifeng Shi, Yifeng Shi, Naifeng Tian, Naifeng Tian, Naifeng Tian, Yifei Zhou, Yifei Zhou, Yifei Zhou, Xiaolei Zhang, Xiaolei Zhang, Xiaolei Zhang, Xiaolei Zhang   +16 more
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The pathological mechanisms of circRNAs in mediating intervertebral disc degeneration

Non-coding RNA Research, 2023
Lower back pain (LBP) is a worldwide health problem associated with significant economic and social burden. Intervertebral disc degeneration (IVDD) is a leading cause of LBP.
Yongjin Li, Suzhe Zhou, Xinli Hu, Shibao Lu   +3 more
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