Results 31 to 40 of about 3,713 (190)

Pretreatment of NPMSCs with Appropriate Concentration of H2O2 Enhances its Ability to Treat IVDD [PDF]

, 2022
Abstract Background: Nucleus pulposus mesenchymal stem cells (NPMSCs) transplantation is a promising treatment for intervertebral disc degeneration (IVDD). However, the transplanted NPMSCs exhibited weak cell proliferation, high cell apoptosis, and low ability to resist the harsh microenvironment of the degenerated intervertebral disc. There is
Yuyao Zhang, Zhilei Hu, Yuhan Qi, Haiyin Li, Xian Chang, Xiaoxin Gao, Chenhao Liu, Yueyang Li, Jinhui Lou, Yu Zhai, Changqing Li   +10 more
openaire   +1 more source

Additional file 1 of Psoralen synergizes with exosome-loaded SPC25 to alleviate senescence of nucleus pulposus cells in intervertebral disc degeneration

, 2023
Additional file 1: Fig. S1. Bioinformatics analysis. Notes: A the key genes were analysed through database GSE34095 in IVDD. B the STRING website analysed protein interactions.
Zhaoyong Li (4685686), Shaofeng Yang (1297038), Lei Yang (102719), Shuofu Li (17273219), Long Chen (315739), Chao Zhang (51048), Yantao Guo (17273222)   +6 more
core   +1 more source

Ex vivo intervertebral disc cultures: degeneration-induction methods and their implications for clinical translation [PDF]

European Cells & Materials, 2023
Because low back pain is frequently a result of intervertebral disc degeneration (IVDD), strategies to regenerate or repair the IVD are currently being investigated.
E Salzer, TC Schmitz, VHM Mouser, A Vernengo, B Gantenbein, JU Jansen, C Neidlinger-Wilke, H-J Wilke, S Grad, CL Le Maitre, MA Tryfonidou, K Ito   +11 more
doaj   +1 more source

DataSheet6_Single-Cell RNA Sequencing of the Nucleus Pulposus Reveals Chondrocyte Differentiation and Regulation in Intervertebral Disc Degeneration.XLSX

, 2022
The nucleus pulposus (NP), a heterogeneous tissue, is an essential functional component of the intervertebral disc. However, NP cell development route and regulation mechanism in intervertebral disc degeneration (IVDD) remain unknown.
Xianjuan Zhang (11630062), Xiaojie Liu (290772), Xuexiao Ma (6841037), Yiran Zhang (1565161), Shuo Han (360375), Meng Kong (1287318), Shengwei Meng (12112032), Hao Zhang (15339)   +7 more
core   +1 more source

FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs [PDF]

, 2017
Significance Chondrodystrophy, characterized by short limbs and intervertebral disc disease (IVDD), is a common phenotype in many of the most popular dog breeds, including the dachshund, beagle, and French bulldog.
Aguilar, Miriam, Sturges, Beverly K, Rachel Pollard, Varon, Samuel, Samuel Varon, Courtney Korff, Tamer Mansour, Miriam Aguilar, Cassandra L. Ettinger, Terje Raudsepp, Bannasch, Danika L, Beverly K. Sturges, Young, Amy E, Brown, Emily A, Dickinson, Peter J, Pollard, Rachel, Jenna Lind, Emily A. Brown, Raudsepp, Terje, Ettinger, Cassandra L, Mansour, Tamer, Lind, Jenna, Amy E. Young, Danika L. Bannasch, Peter J. Dickinson, Brown, C Titus, C. Titus Brown, Korff, Courtney   +27 more
core   +1 more source

Role of Caspase Family in Intervertebral Disc Degeneration and Its Therapeutic Prospects

, 2022
Intervertebral disc degeneration (IVDD) is a common musculoskeletal degenerative disease worldwide, of which the main clinical manifestation is low back pain (LBP); approximately, 80% of people suffer from it in their lifetime.
Deng, Bo, Lei Li, Chen, Haiwei, Bo Deng, Jiale He, Kang, Xuewen, Haiwei Chen, He, Jiale, Zhou, Yuan, Guangzhi Zhang, Zhang, Guangzhi, Luo, Zhangbin, Yuan Zhou, Li, Lei, Xuewen Kang, Zhangbin Luo   +15 more
core   +1 more source

DataSheet1_Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells.PDF

, 2022
Oxidative stress–induced apoptosis and senescence of nucleus pulposus (NP) cells play a crucial role in the progression of intervertebral disc degeneration (IVDD).
Chenglong Xie (8583264), Xiangyang Wang (1857739), Yan Lin (285018), Aimin Wu (311661), Yifeng Shi (1420915), Yaosen Wu (8931335), Peng Luo (488595), Yifei Zhou (5286179), Naifeng Tian (7133387), Zuoxi Chen (11946500), Qishan Huang (11507407), Xin Zhou (54275), Chenxuan Hong (11946503), Xiaolei Zhang (316541), Haicheng Dou (11946506)   +14 more
core   +1 more source

3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease

Bone Research, 2021
Back pain is a common condition with a high social impact and represents a global health burden. Intervertebral disc disease (IVDD) is one of the major causes of back pain; no therapeutics are currently available to reverse this disease.
Erika Kague, Francesco Turci, Elis Newman, Yushi Yang, Kate Robson Brown, Mona S. Aglan, Ghada A. Otaify, Samia A. Temtamy, Victor L. Ruiz-Perez, Stephen Cross, C. Patrick Royall, P. Eckhard Witten, Chrissy L. Hammond   +12 more
doaj   +1 more source

Local Delivery of Senolytic Drug Inhibits Intervertebral Disc Degeneration and Restores Intervertebral Disc Structure

, 2022
Intervertebral disc (IVD) degeneration (IVDD) is a leading cause of chronic low back pain. There is a strong clinical demand for more effective treatments for IVDD as conventional treatments provide only symptomatic relief rather than arresting IVDD ...
Kim, Byung-Soo, Han, Inbo, Song, Seuk Young, Lim, Songhyun, Jung, Mungyo, Kumar, Hemant, Kim, Cheesue, Kang, Mikyung, Lee, Ju-Ro, An, Seong Bae, Joshi, Hari Prasad   +10 more
core   +1 more source

DataSheet1_PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells.PDF

, 2022
Intervertebral disc degeneration (IVDD) is the primary cause of low back pain; however, the molecular mechanisms involved in the pathogenesis of IVDD are not fully understood. Polo-like kinase 1 (PLK1) plays numerous roles in the cell cycle, including in
Zhenlei Zhang (2585365), Di Qiao (3409781), Jianjun Ma (158111), Yizhen Huang (9989915), Shuying Shen (6050849), Nizhen Xu (12238433), Jun Gao (203098), Teng Yao (7550792), Yining Xu (2746033), Jianle Wang (687509)   +9 more
core   +1 more source