Results 51 to 60 of about 3,713 (190)

Ventral Slot Surgery for Management of Ganglioneuroma and IVDD in a Cat

Acta Veterinaria
Abstract A Shorthair castrated 8-year-old tomcat was brought to a veterinary hospital for slowly progressive onset of tetraplegia developing within last 14 days. The clinical and blood examinations at admission showed no abnormalities, the neurological examination showed severe cervical pain and tetraplegia with lower motor neuron ...
Bishal Bhattarai, Mária Kuricová, Tomáš Lipták, Olga Murachova, Olga Chersakova, Nikolay Kozlov, Sergey Pozyabin   +6 more
openaire   +2 more sources

Microenvironment‐Responsive Biomimetic Hydrogels Delivering Cistanche Deserticola‐Derived Nanovesicles for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
An injectable, microenvironment‐responsive hydrogel (HAPOCS@CDNVs) is developed for sustained delivery of Cistanche deserticola‐derived nanovesicles (CDNVs). By scavenging ROS, restoring mitochondrial function, and attenuating SASP, this platform effectively suppresses nucleus pulposus cell senescence and facilitates extracellular matrix reconstruction,
Ning Xu, Xiaoyu Cai, Xiaofu Tang, Weidong Liang, Linsong Teng, Yudong Jing, Haifeng Hu, Yuhao Duan, Mingjie Kuang, Lei Zhang, Shijie Han, Weibin Sheng   +11 more
wiley   +1 more source

Crosstalk Between Ferroptosis and Cuproptosis in Intervertebral Disc Degeneration: Mechanisms, Therapeutic Targets, and Future Directions

JOR Spine
Background Intervertebral disc degeneration (IVDD) is a prevalent degenerative disease, with low back pain as its primary clinical symptom, imposing significant burdens on individuals and society. With the aging population, IVDD is becoming an inevitable
Zhongpan Li, Liangwei Wang, Xiaojun Wu, Rui Huang, Yi Yuan   +4 more
doaj   +1 more source

Differential proteomic analysis of fetal and geriatric lumbar nucleus pulposus: immunoinflammation and age-related intervertebral disc degeneration

BMC Musculoskeletal Disorders, 2020
Background Intervertebral disc degeneration (IVDD) is a major cause of low back pain. Although the mechanism of degeneration remains unclear, aging has been recognized as a key risk factor for IVDD.
Chensheng Qiu, Xiaolin Wu, Jiang Bian, Xuexiao Ma, Guoqing Zhang, Zhu Guo, Yan Wang, Yandong Ci, Qizun Wang, Hongfei Xiang, Bohua Chen   +10 more
doaj   +1 more source

Genetically predicted triglycerides mediate the relationship between type 2 diabetes Mellitus and intervertebral disc degeneration

Lipids in Health and Disease, 2023
Background To validate the causal relationship between type 2 diabetes mellitus (T2DM) and intervertebral disc degeneration (IVDD) and to identify and quantify the role of triglycerides (TGs) as potential mediators.
Ding-Qiang Chen, Wen-Bin Xu, Xin Chen, Ke-Yi Xiao, Zhi-Qiang Que, Nai-Kun Sun, Jin-Yi Feng, Gang Rui   +7 more
doaj   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

DataSheet4_Single-Cell RNA Sequencing of the Nucleus Pulposus Reveals Chondrocyte Differentiation and Regulation in Intervertebral Disc Degeneration.XLSX

, 2022
The nucleus pulposus (NP), a heterogeneous tissue, is an essential functional component of the intervertebral disc. However, NP cell development route and regulation mechanism in intervertebral disc degeneration (IVDD) remain unknown.
Xianjuan Zhang (11630062), Xiaojie Liu (290772), Xuexiao Ma (6841037), Yiran Zhang (1565161), Shuo Han (360375), Meng Kong (1287318), Shengwei Meng (12112032), Hao Zhang (15339)   +7 more
core   +1 more source

Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions

Portal Hypertension &Cirrhosis, EarlyView.
This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley   +1 more source

Single‐Cell Analysis Integrated With Machine Learning Elucidates the Mechanisms of Nucleus Pulposus Cells Apoptosis in Intervertebral Disc Degeneration and Therapeutic Interventions

JOR Spine
Background The molecular of intervertebral disc degeneration (IVDD) is still unclear. When it comes to treating decoction, traditional Chinese medicine is effective.
Chao Song, Xiaofei Wu, Chaoqi Chen, Baoxin Shen, Yongliang Mei, Qian Yan, Feng Jiang, Feng Chen, Fei Liu   +8 more
doaj   +1 more source

Zmpste24 deficiency contributes to intervertebral disc degeneration by undermining the stability of the nuclear membrane of nucleus pulposus cells [PDF]

PeerJ
Intervertebral disc degeneration (IVDD) is often accompanied by the senescence of nucleus pulposus (NP) cells and narrowed intervertebral disc space. Zinc metalloproteinase STE24 (Zmpste24), a common anti-aging gene, has been studied in several diseases ...
Chen Han, Shaotian Fu, Hanyi Wang, Kai Zhang, Jie Zhao   +4 more
doaj   +2 more sources