Results 61 to 70 of about 3,713 (190)

Progress in understanding the role of cGAS-STING pathway associated with programmed cell death in intervertebral disc degeneration

Cell Death Discovery, 2023
Nucleus pulposus (NP) inflammatory response can induce intervertebral disc degeneration (IVDD) by causing anabolic and catabolic disequilibrium of the extracellular matrix (ECM).
Zheng Wang, Xinli Hu, Peng Cui, Chao Kong, Xiaolong Chen, Wei Wang, Shibao Lu   +6 more
doaj   +1 more source

Inter‐rater agreement of the canine modified Ashworth scale for assessment of limb tone in dogs presenting with acute myelopathic signs

Veterinary Record, EarlyView.
Abstract Background This study aimed to assess the inter‐rater reliability of a canine adaptation of the modified Ashworth scale (CaMAS) for the assessment of muscle tone in dogs. Methods Dogs presented to the neurology service of a single referral centre between November 2023 and October 2024 underwent a muscle tone evaluation by two independent ...
Albert Aguilera‐Padros, Joao M. De Frias, Megan Madden, Ana Oliveira, Callum Atkins, Ivona Orgonikova, Aran Nagendran   +6 more
wiley   +1 more source

Sirtuins in intervertebral disc degeneration: current understanding

Molecular Medicine
Background Intervertebral disc degeneration (IVDD) is one of the etiologic factors of degenerative spinal diseases, which can lead to a variety of pathological spinal conditions such as disc herniation, spinal stenosis, and scoliosis.
Jianlin Shen, Yujian Lan, Ziyu Ji, Huan Liu   +3 more
doaj   +1 more source

DataSheet1_Single-Cell RNA Sequencing of the Nucleus Pulposus Reveals Chondrocyte Differentiation and Regulation in Intervertebral Disc Degeneration.DOCX

, 2022
The nucleus pulposus (NP), a heterogeneous tissue, is an essential functional component of the intervertebral disc. However, NP cell development route and regulation mechanism in intervertebral disc degeneration (IVDD) remain unknown.
Xianjuan Zhang (11630062), Xiaojie Liu (290772), Xuexiao Ma (6841037), Yiran Zhang (1565161), Shuo Han (360375), Meng Kong (1287318), Shengwei Meng (12112032), Hao Zhang (15339)   +7 more
core   +1 more source

Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review

, 2022
Intervertebral disc degeneration (IVDD) is a pathological condition that can lead to intractable back pain or secondary neurological deficits. There is no fundamental cure for this condition, and current treatments focus on alleviating symptoms ...
Hideki Sudo, Iwasaki, Norimasa, Sudo, Hideki, Takashi Ohnishi, Norimasa Iwasaki, Ohnishi, Takashi   +5 more
core   +1 more source

Bone mesenchymal stem cells based on matric hydrogels attenuate intervertebral disc degeneration by suppressing oxidative stress-induced ferroptosis

Scientific Reports
Intervertebral disc degeneration (IVDD) and its attendant lower back pain are a major medical challenge. Ferroptosis has become a new target for the treatment of IVDD. Mesenchymal stem cells (MSCs) are a promising regenerative therapy for IVDD.
Song Fu, Renhua Lv, Longqiang Wang, Zhenyu Wang, Fengming Wang, Hao Gao, Wei Zhao, Xiaoling Huang, Xiaojun Li, Yanan Wang   +9 more
doaj   +1 more source

Intervertebral disc degeneration and stroke: A bidirectional two-sample Mendelian randomization study

World Neurosurgery: X
Background: Although previous studies suggest a possible association between intervertebral disc degeneration (IVDD) and stroke, the causal relationship between them remains unclear. Methods: Genetic instrumental variables for IVDD were obtained from the
Yifan Wang, Rong Zhou, Shaoting Nan, Yanlong Duan, Lei Cao, Shenglong Guo   +5 more
doaj   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Image1_Morroniside attenuates nucleus pulposus cell senescence to alleviate intervertebral disc degeneration via inhibiting ROS-Hippo-p53 pathway.jpg

, 2022
Intervertebral disc (IVD) degeneration (IVDD) which is highly prevalent within the elderly population, is a leading cause of chronic low back pain and disability.
Yishan Bian (13809297), Ming Yue (115776), Fangda Fu (9772874), Chengliang Wu (5497649), Sai Yao (6648137), Hongting Jin (8498691), Yuying Ge (13809301), Zhiguo Zhang (147197), Huihao Zhang (13809299), Weifeng Ji (13809303), Hongfeng Ruan (9772880), Chengcong Zhou (9772871), Kun Tian (454216), Yuying Chen (1795294), Huan Luo (244018), Peijian Tong (2549536)   +15 more
core   +1 more source

The role of fenestration in acute canine thoracolumbar intervertebral disc extrusion: Part 2—The biological and biomechanical effects of fenestration

Veterinary Surgery, EarlyView.
Abstract Background Prophylactic fenestration is widely performed to prevent recurrence of canine acute thoracolumbar intervertebral disc extrusion (IVDE); however, there is a paucity of specific data regarding the biological and biomechanical effect of this procedure on the intervertebral disc and vertebral column.
James D. Crowley, Paul Freeman, William R. Walsh   +2 more
wiley   +1 more source