Results 81 to 90 of about 3,713 (190)

CCL3 correlates with ferroptosis in intervertebral disc degeneration and its prognostic significance

Scientific Reports
Intervertebral disc degeneration (IVDD) is a prevalent and debilitating condition associated with low back pain (LBP). Despite its significant impact, effective diagnostic markers for early-stage IVDD remain elusive.
He Chen, Peng Xu, Leijing Mao, Yicong Wang, Zian Feng, Zhongxin Wang, Cailiang Shen, Yuanhong Xu   +7 more
doaj   +1 more source

The protective up-regulation of metallothionein-2A in intervertebral disc degeneration inhibits nucleus pulposus cell ferroptosis through activation of the PI3K/AKT/mTOR pathway

Intervertebral disc degeneration (IVDD) is a major contributor to low back pain, influenced by various factors including cellular senescence, apoptosis, oxidative stress, and inflammation.
Sheng-dan Jiang, Hui Deng, Ze-yu Lu, Jiang, Lei-sheng, Huo-liang Zheng, Chen, Qi-zhu, Mardan, Muradi, Wang, Yong, Shao-kuan Song, Xin-feng Zheng, Qing-yin Xu, Zheng, Huo-liang, Muradi Mardan, Cai, Hao, Bo Li, Zheng, Xin-feng, Lu, Ze-yu, Li, Bo, Hao Cai, Yang, Bing-yi, Bing-yi Yang, Jiang, Sheng-dan, Song, Shao-kuan, Lei-sheng Jiang, Qi-zhu Chen, Peng-bo Chen, Chen, Peng-bo, Xu, Qing-yin, Yong Wang, Deng, Hui   +29 more
core   +1 more source

Gubi Decoction Ameliorates Porous Cartilage Endplate in an Intervertebral Disc Degeneration Model Mouse Through Inhibition of NF-κB Activity and Pyroptosis

Journal of Inflammation Research
Sai Yao,1– 4,* Yanan Li,1,3,* Hongfeng Ruan,3,4 Lianguo Wu,1 Hanbing Zeng1 1Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310005, People’s Republic of China; 2Frontier ...
Yao S, Li Y, Ruan H, Wu L, Zeng H
doaj  

Hydrogel-Based Biomaterials in Spinal Repair: Evaluating Mechanisms for IVDD, SCI, and Dural Regeneration

Journal of Multidisciplinary Healthcare
Spinal disorders, such as intervertebral disc degeneration (IVDD) and spinal cord injury (SCI), pose substantial challenges in modern healthcare, exacerbated by an aging population and the limited effectiveness of current treatments. IVDD, characterized by extracellular matrix (ECM) degradation, dehydration of the nucleus pulposus, and inflammation, is
Yibo Wang, Ya Guo, Dianyu Zhang
openaire   +4 more sources

Influence of duration of clinical signs on surgical treatment results of 16 dogs with intervertebral disc disease (IVDD)

Bulletin of the Veterinary Institute in Pulawy, 2014
Abstract The purpose of this study was to evaluate the outcome of surgical treatment in 16 dogs, depending on the animal’s age, body weight, deep pain perception, and time from the onset of neurological symptoms to the consultation with a veterinary neurologist and successive surgery.
Marcin Wrzosek, Zdzisław Kiełbowicz, Elżbieta Giza, Marta Płonek, Józef Nicpoń   +4 more
openaire   +2 more sources

SOD1 lactylation impair its enzymatic activity by conformational change to aggravate intervertebral disc degeneration

Nature Communications
Lactate accumulation is a hallmark and contributing factor of intervertebral disc degeneration (IVDD), while the role of protein lactylation caused by lactate accumulation in IVDD remains unclear.
Yuyao Zhang, Yu Zhai, Chao Liu, Minghang Chen, Yang Zhang, Zhiqun Bian, Xian Chang, Zhilei Hu, Jianmin Li, Chao Zhang, Zhenhong Ni, Yangli Xie, Lin Chen, Minghan Liu, Changqing Li   +14 more
doaj   +1 more source

Nucleus Pulposus Cell Senescence in IVDD: Mechanisms and Therapeutic Perspectives

International Journal of Biology and Life Sciences
Intervertebral disc degeneration (IVDD) is a common spinal pathological process that leads to the degeneration of the structure and function of the intervertebral disc, causing low back pain and nerve root compression. The molecular mechanism of intervertebral disc degeneration is not fully understood, but cellular senescence is an important factor ...
openaire   +1 more source

Mast Cells and Their Related Gene HK-1 are Closely Associated with Discogenic Low Back Pain: A Bioinformatics and Clinical Sample Study

Journal of Pain Research
Shouyu He,1,* Xiaowen Liu,2,* Shenchang Luo,1 Haidong Li,1 Jikang Min,1 Qian Shi3 1Department of Spine Surgery, First Affiliated Hospital, The First People’s Hospital of Huzhou, Huzhou University, Huzhou, 313000, People’s Republic of China ...
He S, Liu X, Luo S, Li H, Min J, Shi Q
doaj  

The role of micronutrients and serum metabolites in intervertebral disk degeneration: insights from a Mendelian randomization study and mediation analysis

Frontiers in Nutrition
BackgroundIntervertebral disk degeneration (IVDD) is a complex degenerative skeletal condition, potentially influenced by micronutrients and serum metabolites in its etiology.
Nizhou Jiang, Nizhou Jiang, Quanxiang Wang, Jian Jiang, Jian Jiang, Lei Li   +5 more
doaj   +1 more source

Machine learning-enabled identification of nucleus pulposus senescence-associated genes as potential biomarkers for intervertebral disc degeneration

European Journal of Medical Research
Background Intervertebral disc degeneration (IVDD) has risen to become a global health problem, and its mechanisms are not well understood. The aim of this study was to use machine learning methods to identify key medullary senescence genes associated ...
Min Xiang, Qingping Peng, Feifei Dai, Yanjiao Wu, Ling Liu, Huan Liu   +5 more
doaj   +1 more source