Results 101 to 110 of about 3,713 (190)

Construction of circ_0071922‐miR‐15a‐5p‐mRNA network in intervertebral disc degeneration by RNA‐sequencing

JOR Spine
Background Low back pain (LBP) is the main factor of global disease burden. Intervertebral disc degeneration (IVDD) has long been known as the leading reason of LBP.
Yongjin Li, Baobao Wang, Wenzhi Sun, Chao Kong, Junzhe Ding, Feng Hu, Jianhua Li, Xiaolong Chen, Shibao Lu   +8 more
doaj   +1 more source

Mesenchymal Stromal Cell Response to Degenerated Intervertebral Disc-Like PH [PDF]

Intervertebral disc degeneration (IVDD) has become increasingly prevalent and is a common contributing factor to low back pain. There are currently no clinical treatment options for IVDD that alleviate the symptoms of IVDD while simultaneously promoting ...
Cannon, Kyle
core  

Identifying Myeloid-Derived Suppressor Cells and Lipocalin-2 as Therapeutic Targets for Intervertebral Disc Degeneration

Inflammation is a hallmark of intervertebral disc degeneration (IVDD) characterized by immune cell infiltration and cytokine secretion. Stage-specific transcriptomic analyses of IVDD via single-cell RNA sequencing (scRNA-seq) have primarily focused on ...
Chan, Ying Shing, Wang, Yu, Shea, Graham Ka Hon, Wang, Hongfei, Shi, Liangyu, Zhang, Changmeng, Li, Haoyun   +6 more
core   +1 more source

Velutin Inhibits IL-1β-Induced Nucleus Pulposus Inflammatory and Extracellular Matrix Degradation Attenuating Mouse Intervertebral Disc Degeneration via the NF-κB and MAPK Pathways

Mediators of Inflammation
Intervertebral disk degeneration (IVDD) usually causes lower back pain (LBP). Mechanical stress, trauma, aseptic inflammation, infection, and genetic susceptibility can accelerate the development of IVDD.
Yufeng Zhang, Rongjian Xu, Kelei Wang, Xinyu Li, Yun Lou, Li Cao, Wanlei Yang, Yu Qian   +7 more
doaj   +1 more source

Causal associations between abdominal obesity, dietary patterns, and intervertebral disc degeneration: a bidirectional two-sample Mendelian randomization study with clinical validation

BackgroundThe relationship between abdominal obesity, dietary habits, and intervertebral disc degeneration (IVDD) remains incompletely understood, particularly from a causal perspective.
ZhongHao Dai, Ling, GuoYu, Wang, Xu, Pan, JiaoYi, ZiTong Zhang, Mao, XingYong, YiTing Wang, Xu, Bing, ZeZhong Liu, Dai, ZhongHao, Liu, ZeZhong, Xu Wang, JiaoYi Pan, XingYong Mao, BaiTong Zhao, Bing Xu, GuoYu Ling, Zhao, BaiTong, Zhang, ZiTong, Wang, YiTing   +19 more
core   +1 more source

Causal relationship between intervertebral disc degeneration and osteoporosis: a bidirectional two-sample Mendelian randomization study

Frontiers in Endocrinology
IntroductionThe relationship between intervertebral disc degeneration (IVDD) and osteoporosis (OP), diagnosed primarily using bone mineral density (BMD), remains unclear so far.
Gaohua Liu, Hanjing Zhang, Meichun Chen, Wenkang Chen   +3 more
doaj   +1 more source

Single-cell and spatial transcriptomics characterisation of RSPO2+ nucleus pulposus cells reveals a WNT/FN1–CD44 degenerative axis and therapeutic targets in IVDD

Journal of Orthopaedic Translation
Intervertebral disc degeneration (IVDD) is a common cause of chronic low back pain, imposing a significant economic and physiological burden on individuals and society worldwide. Although dysregulation of the WNT/β-catenin pathway is considered an important factor contributing to the dysfunction of nucleus pulposus (NP) cells and degradation of the ...
Li, Qiuwei, Liang, Guoyan, Bo, Kaida, Kang, Liang, Jin, Peilin, Zhao, Chenhao, Zhang, Renjie, Lyu, Fengjuan, Shen, Cailiang   +8 more
openaire   +3 more sources

Hypoxic-inflammatory preconditioning endows BMSC-derived appoptotic extracellular vesicles with potent efficacy against IVDD via cell activation and mitochondrial homeostasis regulation

Journal of Nanobiotechnology
Intervertebral disc degeneration (IVDD) is the primary cause of chronic low back pain, with the senescence of nucleus pulposus cells (NPCs) as its core driving mechanism. Mitochondrial homeostasis acts as a critical mediator linking cellular stress responses to the senescence program of nucleus pulposus cells.
Zhang, Weiqi, Guo, Tianhao, Miao, Dazhuang, Ma, Xiaowei, Chen, Wei, Hou, Zhiyong, Zhang, Yingze, Gao, Xianda, Zhang, Di   +8 more
openaire   +2 more sources

Assessment of degradation of proteoglycans and matrix proteins in intervertebral disc degeneration by diffusion weighted MRS

, 2013
This study investigated the capability of diffusion weighted magnetic resonance spectroscopy (DW-MRS) for assessing the changes in carbohydrates region (3.5-4.2ppm) during intervertebral disc degeneration (IVDD).
Wang, AM, Cao, P, Yang, J, Wu, EX
core  

Intervertebral Disc Disease (IVDD) – Anatomical Factors Contributing to Disc Herniation in Dogs

Introduction The spinal column is designed to provide both stability and flexibility. At its core, the intervertebral disc acts as a resilient cushion, allowing movement while protecting the delicate spinal cord. Each disc comprises two primary anatomical components: the central nucleus pulposus, a gelatinous core, and the surrounding annulus fibrosus,
openaire   +2 more sources