Results 91 to 100 of about 3,713 (190)

Magnetic resonance imaging findings in dogs with thoracolumbar intervertebral disk disease: 69 cases (1997-2005)

, 2006
Besalti, Omer/0000-0002-7819-9094;Objective-To determine magnetic resonance imaging (MRI) abnormalities in dogs with intervertebral disk disease (IVDD) and develop a classification scheme for IVDD in dogs based on MRI findings.
Erbaş, Gonca, Şirin, Y. Sinan, Beşaltı, Ömer, Pekcan, Zeynep, Pekcan, Z, Besalti, O, Sirin, YS   +6 more
core   +1 more source

RBX1 mitigates ferroptosis by inhibiting NCOA4-mediated ferritinophagy and contributes to the attenuation of intervertebral disc degeneration

Journal of Translational Medicine
Loss of nucleus pulposus (NP) cells is as one of the primary factors initiating intervertebral disc (IVD) degeneration (IVDD); however, the intrinsic physiological mechanisms of endogenous NP-derived stem cell (NPSC)-based therapy in IVDD remain poorly ...
Lu-Ping Zhou, Liang Kang, Zhi-Gang Zhang, Chong-Yu Jia, Chen-Hao Zhao, Xian-Liang Zhang, Hua-Qing Zhang, Ren-Jie Zhang, Cai-Liang Shen   +8 more
doaj   +1 more source

RETRACTED: SR9009 attenuates inflammation-related NPMSC pyroptosis and IVDD through NR1D1/NLRP3/IL-1β pathway

iScience
Intervertebral disc is a highly rhythmical tissue. As a key factor linking biorhythm and inflammatory response, the shielding effect of NR1D1 in the process of intervertebral disc degeneration remains unclear. Here, we first confirmed that NR1D1 in the nucleus pulposus tissue presents periodic rhythmic changes and decreases in expression with ...
Ze-Nan Huang, Jing Wang, Ze-yu Wang, Ling-yuan Min, Hai-Ling Ni, Yan-Ling Han, You-yue Tian, Ya-Zhou Cui, Jing-Xiang Han, Xiao-Fei Cheng   +9 more
openaire   +3 more sources

Intervertebral Disk Disease in Dogs (IVDD) in Dogs

Canine intervertebral disc disease (IVDD) is a painful spinal condition that requires veterinary management for the best chance of improvement.  The health of your dog’s spine is important for walking, sending signals between the body and the brain, elimination of feces and urine, and more.
openaire   +2 more sources

Methylmalonic Acid, an Aging\u2010Associated Metabolite, Accelerates Intervertebral Disc Degeneration by Inducing Disc Vascularization via the CCL7/JAK2\u2010STAT3/VEGF Signaling Axis

Intervertebral disc degeneration (IVDD) is an age\u2010related degenerative spinal disorder, with age as the primary independent risk factor. To investigate the key pathogenic mechanisms of IVDD, we conducted biochemical analyses on IVD specimens from ...
Zhao, Xiaofeng, Wang, Xiaonan, Jin, Yuanzhang, Jing, Doudou, Zhao, Bin, Zhou, Runtian, Liu, Haifeng   +6 more
core   +1 more source

Targeted modulation of phosphate and lipid metabolism reduces ligament mineralization in col9a1b deficient zebrafish

Intervertebral disc degeneration (IVDD) is a major global cause of back pain and disability in the elderly, characterized by matrix breakdown, ligament mineralization, and pain. Effective pharmacological treatments for IVDD are currently unavailable.
Joanna Moss, Bianca Ventura Fernandes, Renata A. Raele, Chrissy L. Hammond, Erika Kague, Beatriz Larraz Prieto   +5 more
core   +1 more source

The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration

Bone Research
Intervertebral disc degeneration (IVDD) is the primary contributor to a range of spinal diseases. Dynamin-related protein 1 (Drp1)-mediated mitochondrial fission has recently been identified as a new cause of nucleus pulposus cell (NPC) death and IVDD ...
Zhidi Lin, Xiao Lu, Guangyu Xu, Jian Song, Hongli Wang, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Wei Zhu, Zuochong Yu, Xiaosheng Ma, Fei Zou   +11 more
doaj   +1 more source

Nucleotide polymorphism-based study utilizes human plasma liposomes to discover potential therapeutic targets for intervertebral disc disease

Frontiers in Endocrinology
BackgroundWhile intervertebral disc degeneration (IVDD) is crucial in numerous spinally related illnesses and is common among the elderly, the complete understanding of its pathogenic mechanisms is still an area of ongoing study.
Ding-Qiang Chen, Ding-Qiang Chen, Zhi-Qiang Que, Wen-Bin Xu, Ke-Yi Xiao, Ke-Yi Xiao, Nai-Kun Sun, Hong-Yu Song, Jin-Yi Feng, Guang-Xun Lin, Guang-Xun Lin, Gang Rui, Gang Rui   +12 more
doaj   +1 more source

Rescuing ACE2‐Deficiency‐Mediated Nucleus Pulposus Senescence and Intervertebral Disc Degeneration by a Nanotopology‐Enhanced RNAi System

Advanced Science
Nucleus pulposus cell (NPC) senescence contributes to intervertebral disc degeneration (IVDD). However, the underlying molecular mechanisms are not fully understood.
Kaiqiang Sun, Zijian Kang, Chen Yan, Yan Yu, Linhui Han, Yangyang Shi, Liang Chen, Jiangang Shi, Yu Chen, Jingchuan Sun   +9 more
doaj   +1 more source

Mechanobiology of intervertebral disc degeneration: From pathological mechanisms to therapeutic approaches

Intervertebral disc degeneration (IVDD) is a complex mechanobiological process driven by abnormal mechanical loading, resulting in structural failure, inflammatory activation, and cellular dysfunction.
Kai Zhang, Jie Zhao, Han Qiao
core   +1 more source