Results 71 to 80 of about 3,713 (190)

Exoskeleton Assistive Device for Dachshunds with IVDD

Intervertebral disc disease (IVDD) causes instability and pain to the hind limbs of dogs and is especially prevalent in Dachshunds. Current treatment and rehabilitation methods like hydrotherapy and braces lack consistent support in everyday movements ...
McDonagh, Kylie, Yawata, Kai, King, Jonathan   +2 more
core   +2 more sources

BRD-K20733377 inhibits ferroptosis and alleviates intervertebral disc degeneration via the STAT3/NFKB1 axis: a multiapproach study

Stem Cell Research & Therapy
Introduction Intervertebral disc degeneration (IVDD) is one of the main causes of low back pain. Existing literature has confirmed the occurrence of ferroptosis in IVDD.
Hua Sun, Xuan You, Zhaoyu Li, Zhengguang Li, Benkui Hua, Chen Liu, Yongbo Zhang, Huofeng Wu, Shuangjia Zai, Liang Zhang   +9 more
doaj   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, Volume 13, Issue 62, 9 November 2026.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Targeting Ferroptosis Holds Potential for Intervertebral Disc Degeneration Therapy

, 2022
Intervertebral disc degeneration (IVDD) is a common pathological condition responsible for lower back pain, which can significantly increase economic and social burdens.
Qiaochu Li, Linbang Wang, Feng, Yi, Wang, Linbang, Li, Qiaochu, Quan, Zhengxue, Yang, Xinyu, Zhengxue Quan, Ma, Jingjin, Yi Feng, Jingjin Ma, Chen, Jiaxing, Jiaxing Chen, Xinyu Yang   +13 more
core   +1 more source

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang, Siwen Wu, Yusi Wang, Die Hu, Li Yang   +4 more
wiley   +1 more source

Table1_IGF Signaling in Intervertebral Disc Health and Disease.DOCX

, 2022
Low back pain (LBP) is a common musculoskeletal symptom, which brings a lot of pain and economic loss to patients. One of the most common causes of LBP is intervertebral disc degeneration (IVDD).
Ling Wu (151826), Xiangcheng Qing (4097737), Yizhong Peng (11434741), Shuo Tian (4516609), Yan Xiao (91196), Hui Lin (161703), Zengwu Shao (4097731)   +6 more
core   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

The Relationship between Diabetes Mellitus Type II and Intervertebral Disc Degeneration in Diabetic Rodent Models: A Systematic and Comprehensive Review

, 2020
The number of diabetic patients grows constantly worldwide. Many patients suffer simultaneously from diabetes mellitus type 2 (T2DM) and intervertebral disc disease (IVDD), suggesting a strong link between T2DM and IVDD.
Alexander Auffarth, Gundula Schulze-Tanzil, Mohamed Mahmoud, Maria Kokozidou   +3 more
core   +1 more source

Piezo1 promotes intervertebral disc degeneration through the Ca2+/F-actin/Yap signaling axis

Molecular Medicine
Background Piezo1 is a mechanically sensitive cation channel expressed in various tissues of the human body and has multiple roles in both physiological and pathological processes.
Fushuai Peng, Mingtong Sun, Xingzhi Jing, Fei Chen, Tong Cao, Zhenzhen Li, Tao Li   +6 more
doaj   +1 more source

Advanced hydrogel therapeutics for intervertebral disc degeneration: Engineering structural–functional properties in natural and synthetic biomaterials

Low back pain is a global health challenge, imposing substantial socioeconomic burdens. Intervertebral disc degeneration (IVDD) is a leading cause of low back pain and can lead to further spinal complications.
Tao Chen, Huiyi Yang, Rongrong Zhu, Zhaojie Wang, Zhihui Xiao, Dading Lu, Pooyan Makvandi, Liming Cheng, Wenyong Fan, Siqiao Wang   +9 more
core   +1 more source