Results 41 to 50 of about 3,713 (190)

Duhuo Jisheng Decoction ameliorates experimental intervertebral disc degeneration by modulating immune-inflammatory responses through regulation of macrophage polarization

Frontiers in Immunology
BackgroundThe predominant cause of lower back pain (LBP) is intervertebral disc degeneration (IVDD), which has a substantial financial cost to both individuals and society. In the pathophysiology of IVDD, the immune-inflammatory response is crucial.
Yongliang Mei, Liquan Wang, Chao Song, Rui Lv, Xianping Xie, Zongchao Liu, Zongchao Liu   +6 more
doaj   +1 more source

IGF Signaling in Intervertebral Disc Health and Disease

Frontiers in Cell and Developmental Biology, 2022
Low back pain (LBP) is a common musculoskeletal symptom, which brings a lot of pain and economic loss to patients. One of the most common causes of LBP is intervertebral disc degeneration (IVDD).
Hui Lin, Shuo Tian, Yizhong Peng, Ling Wu, Yan Xiao, Xiangcheng Qing, Zengwu Shao   +6 more
doaj   +1 more source

Biomimetic nanoplatforms modulating mitochondrial pathways in IVDD

Journal of Nanobiotechnology
To develop and evaluate a mitochondria-targeted biomimetic nanoplatform (nMitoQ-SNA-CMT) for the treatment of intervertebral disc degeneration (IVDD).A rat IVDD model and an H2O2-induced oxidative stress model in nucleus pulposus cells (NPCs) were established to investigate the effects of nMitoQ-SNA-CMT on mitochondrial function, oxidative stress ...
Jian-Bin, Guan, Shan-Xi, Wang, Ying-Guang, Wang, Kai-Yuan, Lin, Ren-Ji, Wang, Rui-Rui, Bu, Yuan-Ting, Zhao, Si-Bo, Wang, Ling-Jiang, Li, Xiao-Jun, Yu   +9 more
openaire   +2 more sources

Table2_IGF Signaling in Intervertebral Disc Health and Disease.DOCX

, 2022
Low back pain (LBP) is a common musculoskeletal symptom, which brings a lot of pain and economic loss to patients. One of the most common causes of LBP is intervertebral disc degeneration (IVDD).
Ling Wu (151826), Xiangcheng Qing (4097737), Yizhong Peng (11434741), Shuo Tian (4516609), Yan Xiao (91196), Hui Lin (161703), Zengwu Shao (4097731)   +6 more
core   +1 more source

Biomaterials delivery strategies to repair degenerated intervertebral discs by regulating the inflammatory microenvironment [PDF]

, 2023
Intervertebral disc degeneration (IVDD) is one of the leading causes of lower back pain. Although IVDD cannot directly cause death, it can cause pain, psychological burdens, and economic burdens to patients.
Xia, Yuanliang, Yuehong Li, Zhu, Jianshu, Wang, Hengyi, Li, Yuehong, Hengyi Wang, Changfeng Fu, Ruohan Yang, Yang, Ruohan, Jianshu Zhu, Hou, Yulin, Fu, Changfeng, Yulin Hou, Yuanliang Xia   +13 more
core   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Current Understanding of the Genetics of Intervertebral Disc Degeneration. [PDF]

, 2020
Premature degeneration of the intervertebral disc and its association with specific chondrodystrophic dog breeds has been recognized for over a century. Several lines of evidence including disease breed predisposition, studies suggesting heritability of ...
Bannasch, Danika L, Dickinson, Peter J
core   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Melatonin attenuates degenerative disc degression by downregulating DLX5 via the TGF/Smad2/3 pathway in nucleus pulposus cells

JOR Spine
Background Intervertebral disc degeneration (IVDD) is the leading cause of low back pain, and apoptosis plays a key role in its pathogenesis. Distal‐less homeobox 5 (Dlx5) has been reported to induce cell apoptosis. Melatonin, as a powerful antiapoptotic
Kuibo Zhang, Hua Wang, Ling Mo, Xiaohui Huang, Chao Yuan, Caijun Liu   +5 more
doaj   +1 more source

The role of ferroptosis in intervertebral disc degeneration

Frontiers in Cell and Developmental Biology, 2023
Nucleus pulposus, annulus fibrosus, and cartilage endplate constitute an avascular intervertebral disc (IVD), which is crucial for spinal and intervertebral joint mobility.
Chunyang Fan, Genglei Chu, Zilin Yu, Zhongwei Ji, Zhongwei Ji, Fanchen Kong, Lingye Yao, Jiale Wang, Dechun Geng, Xiexing Wu, Haiqing Mao   +10 more
doaj   +1 more source