Results 21 to 30 of about 3,713 (190)

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk [PDF]

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +2 more sources

MicroRNA-199a-5p accelerates nucleus pulposus cell apoptosis and IVDD by inhibiting SIRT1-mediated deacetylation of p21 [PDF]

Molecular Therapy: Nucleic Acids, 2021
Intervertebral disc degeneration (IVDD) is a multifactorial pathological process associated with low back pain in which nucleus pulposus cell senescence is disrupted.
Yiqiang Sun, Xia Wang, Guoyong Fu, Xiaopeng Geng   +3 more
doaj   +3 more sources

Causal Relationship Between Cerebrospinal Fluid Metabolites and Intervertebral Disc Disease: A Bidirectional Mendelian Randomization Study

Diagnostics
Background: Intervertebral disc degeneration (IVDD) is caused by an imbalance between the catabolic and anabolic processes within intervertebral disc tissue.
Jiheng Xiao, Tianyi Xia, Xianglong Zhou, Xin Xing, Yanbin Zhu, Yingze Zhang, Liming Xiong   +6 more
doaj   +2 more sources

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration [PDF]

Advanced Science, Volume 13, Issue 62, 9 November 2026.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +2 more sources

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation [PDF]

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +2 more sources

Assessing the causal relationship between CRP, IL-1α, IL-1β, and IL-6 levels and intervertebral disc degeneration: a two-sample Mendelian randomization study

Scientific Reports
Growing research has suggested an association between chronic inflammation and Intervertebral disc degeneration (IVDD), but whether there is a causal effect remains unknown.
Xin-an Yan, Erdong Shen, Aiyong Cui, Fengjin Zhou, Yan Zhuang   +4 more
doaj   +2 more sources

Causal relationship of interferon-γ and interleukin-18 upstream of intervertebral disc degeneration pathogenesis: a two-sample Mendelian randomization study [PDF]

Frontiers in Neurology
IntroductionIntervertebral disc degeneration (IVDD) is a complex disease caused by genetic and environmental factors, but its pathogenesis is still unclear.
Fang Gao, Chen Deng, Zhiqiang Wang, Beiyang Wang, Junqiao Lv, Lin Sun   +5 more
doaj   +2 more sources

Classification of Intervertebral Disc Disease [PDF]

Frontiers in Veterinary Science, 2020
Intervertebral disc disease (IVDD) has been recognized in dogs since the 1800s, when the first descriptions of extruded disc material within the vertebral canal were published. In the intervening time our understanding of intervertebral disc pathology in
Joe Fenn, Natasha J. Olby, The Canine Spinal Cord Injury Consortium (CANSORT-SCI), Sarah A. Moore, Natasha J. Olby, Kady M. Gjessing, Rhanna M. Davidson, Jonathan M. Levine, Helen McWhorter, Melissa J. Lewis, Nick D. Jeffery, Maureen E. Mullins, Ronaldo Casimiro da Costa, Yvette S. Nout-Lomas, Joe Fenn, Nicolas Granger, Ingo Spitzbarth, Veronika M. Stein, Andrea Tipold, Ji-Hey Lim, Holger Volk   +20 more
doaj   +2 more sources

Integrated Multi-Omics Analysis and Experimental Validation Identify UBE2Q2 as a Candidate Molecule Target in Intervertebral Disc Degeneration. [PDF]

J Cell Mol Med
Intervertebral disc degeneration (IVDD) is a primary cause of low back pain, with its molecular mechanisms remaining incompletely understood. Ubiquitin‐conjugating enzymes (E2 enzymes) play critical roles in protein degradation and maintenance of ...
Cheng W, Yang J, Liu F, Chen M, Pan H, Wang D, Qi W, Hu J.   +7 more
europepmc   +2 more sources

ITGBL1 and RPN1 Mark a Fibrotic NP Subpopulation with Coupled Integrin Signaling and N-Glycosylation Programs in IVDD [PDF]

Journal of Inflammation Research
Shuo Qiang, Yunke Liu, Yonghui Dong, Cheng Cheng, Yifan Huang, Jia Zheng, Chao Tang, Siyu Zhao   +7 more
openaire   +2 more sources