Results 151 to 160 of about 65,024 (264)

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Progressive multifocal leukoencephalopathy in a young adult with DOCK8 deficiency: a case of JC virus reactivation in primary immunodeficiency. [PDF]

J Neurovirol
Naydovich L, Berger JR, Milutinovic PS.
europepmc   +1 more source

Database and Statistical Analyses of Transcription Factor Binding Sites in the Non-Coding Control Region of JC Virus. [PDF]

Viruses, 2021
Nakamichi K, Shimokawa T.
europepmc   +1 more source

Single Cell Multi‐Omics Revealing the Important Role of MR1 Mediated MAIT Cells in Maintaining Rejection for Liver Transplantation

Cell Proliferation, EarlyView.
This multi‐omics study reveals the significant role of MAIT cells in liver transplant rejection. MAIT cells drive rejection in liver transplantation via the MR1 axis. Their absence reshapes T cell responses and clonal expansion, attenuating allograft injury.
Hailun Cai, Xinqiang Li, Xin Zhou, Xueteng Wang, Zhuoyu Jia, Ruidong Ding, Yurong Luo, Ye Wang, Shipeng Li, Wenxing Sun, Dongxing Wu, Dahong Teng, Kai Zhao, Guanghui Pei, Jinzhen Cai, Bin Wu   +15 more
wiley   +1 more source

A comparison of JC virus assay performance provided with originator and biosimilar natalizumab. [PDF]

Mult Scler
Varley J, Beyrouti R, Nicholas R, Dorsey R, Brownlee W, Paling D, Mathews J, Dobson R.   +7 more
europepmc   +1 more source

MAVS oligomerization drives a faster and more efficient antiviral signaling activation at peroxisomes compared to mitochondria

The FEBS Journal, EarlyView.
Cells rely on mitochondria and peroxisomes to trigger antiviral defenses via the protein MAVS. This manuscript demonstrates that the robust production of antiviral effectors resulting from MAVS activation at peroxisomes is faster than at mitochondria due to a swifter oligomerization of this protein at peroxisomal membranes. These results underscore the
Bruno Ramos, Jéssica Sarabando, Mariana Marques, Jonathan C. Kagan, Daniela Ribeiro   +4 more
wiley   +1 more source

JC Virus Agnogene Regulates Histone-Modifying Enzymes via PML-NBs: Transcriptomics in VLP-Expressing Cells. [PDF]

Viruses
Shishido-Hara Y, Yaoi T.
europepmc   +1 more source

Human neurotropic polyomavirus, JC virus, agnoprotein targets mitochondrion and modulates its functions. [PDF]

Virology, 2021
Saxena R, Saribas S, Jadiya P, Tomar D, Kaminski R, Elrod JW, Safak M.   +6 more
europepmc   +1 more source

Perinatal and early infant outcomes after first‐versus second‐generation integrase strand transfer inhibitor use in pregnancy

HIV Medicine, EarlyView.
Abstract Introduction Integrase strand transfer inhibitors (INSTIs) are first‐line antiretroviral medications used in pregnancy. Pre‐clinical research suggests adverse effects in human stem cells associated with second‐ versus first‐generation INSTIs.
Rosa Balleny, Jeffrey Man Hay Wong, Terry Lee, Ari Bitnun, Isabelle Boucoiran, Jason Brophy, Jeannette Comeau, Fatima Kakkar, Athena McConnell, Laura Sauvé, Joel Singer, Alena Tse‐Chang, Deborah Money   +12 more
wiley   +1 more source

CRISPR-based assays for the detection of BK virus and JC virus infections post-kidney transplantation. [PDF]

Mil Med Res
Liu Y, Xu JS, Cao L, Yang S, Li TM, Huang HQ, Zhang JH, Zhao X, Liu Q, Li S, Li M, Wang H.   +11 more
europepmc   +1 more source