Mitochondrial tRNAGlu 14687A>G May Be A Novel Mutation for Type 2 Diabetes Mellitus
Journal of Clinical Laboratory Analysis, EarlyView.We identified a novel mitochondrial tRNAGlu 14687A>G mutation in a Han Chinese pedigree with diabetes; the m.14687A>G mutation occurred at a conserved nucleotide of tRNAGlu, which was important for tRNA structure and function. Using a cybrid cell model, we found that mutant cells exhibited much more severe mitochondrial dysfunctions than control cells,
Xiaojuan Rao +3 more
wiley +1 more source
Human neurotropic polyomavirus, JC virus, late coding region encodes a novel nuclear protein, ORF4, which targets the promyelocytic leukemia nuclear bodies (PML-NBs) and modulates their reorganization. [PDF]
Virology, 2023 Saribas AS +5 more
europepmc +1 more source
Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib
The Journal of Clinical Pharmacology, EarlyView.Abstract Fruquintinib (FRUZAQLATM) is a highly selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3). Two Phase 1, open‐label, single‐dose studies investigated the impact of hepatic or renal impairment on the pharmacokinetics and tolerability of fruquintinib.
Martha Gonzalez +8 more
wiley +1 more source
Database and Statistical Analyses of Transcription Factor Binding Sites in the Non-Coding Control Region of JC Virus. [PDF]
Viruses, 2021 Nakamichi K, Shimokawa T.
europepmc +1 more source
A Survey on Methotrexate Prescribing and Monitoring Practices in Ireland
JEADV Clinical Practice, EarlyView.ABSTRACT Background Methotrexate, originally an anti‐neoplastic agent, is now extensively used at lower doses in dermatology and rheumatology for chronic inflammatory conditions. While its safety is supported by routine blood monitoring, there remains variability in recommended monitoring frequency, folic acid supplementation, liver function testing ...
Ji Fung Yong +7 more
wiley +1 more source
Adoptive Transfer of JC Virus-Specific T Lymphocytes for the Treatment of Progressive Multifocal Leukoencephalopathy. [PDF]
Ann Neurol, 2021 Berzero G +21 more
europepmc +1 more source
Naval Research Logistics (NRL), EarlyView.ABSTRACT The COVID‐19 pandemic has reverberated across global industries, including the international container shipping industry, where freight rates have become highly volatile. However, shipping lines appeared to thrive, particularly during the pandemic's initial 2 years.
Shiyuan Zheng, Changmin Jiang
wiley +1 more source
Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease. [PDF]
Nat Rev Neurol, 2021 Cortese I, Reich DS, Nath A.
europepmc +1 more source
Beta cells to brain cells: The pivotal role of insulin and glucose metabolism in Alzheimer's disease
Neuroprotection, EarlyView.Common metabolic, histochemical, and molecular pathologies: Type 2 diabetes and dementia. Abstract The risk factors and neuropathologies of cognitive decline and the onset and progression of dementia‐related disorders were, until recently, obtuse. A critical predisposing factor to Alzheimer's disease (AD) that has emerged is glucose dysmetabolism.
Stanley S. Schwartz +3 more
wiley +1 more source
Central nervous system disease with JC virus infection in adults with congenital HIV. [PDF]
AIDS, 2021 McEntire CRS +7 more
europepmc +1 more source