Upregulation of the NKG2D Ligand ULBP2 by JC Polyomavirus Infection Promotes Immune Recognition by Natural Killer Cells. [PDF]
J Infect DisJost S +11 more
europepmc +1 more source
Human polyomaviruses JCPyV and MCPyV in urothelial cell carcinoma: a single institution experience
Frontiers in Oncology, 2023 ObjectiveUrothelial cell carcinoma (UCC) is the most common type of urinary bladder. JCPyV and BKPyV have been detected in the urine and tissue of urothelial cell carcinomas (UCC) in immunocompetent patients. Here, we investigated the presence of several HPyVs in UCC samples using diverse molecular techniques to study the prevalence of HPyVs in UCC ...
Faisal Klufah +2 more
exaly +4 more sources
JCPyV microRNA in plasma inversely correlates with JCPyV seropositivity among long-term natalizumab-treated relapsing-remitting multiple sclerosis patients [PDF]
Journal of NeuroVirology, 2017 Sensitive biomarkers are needed to better manage multiple sclerosis (MS) patients for natalizumab (NTZ)-associated risk of progressive multifocal leukoencephalopathy (PML). A currently used risk stratification algorithm, mainly based on JC polyomavirus (JCPyV) serology, has not led to a reduction of PML incidence.
Elina Virtanen +2 more
exaly +5 more sources
Detection of human neurotropic JCPyV DNA sequence in pediatric anaplastic xanthoastrocytoma
Journal of NeuroVirology, 2023 AbstractDue to its peculiar histopathological findings, pleomorphic xanthoastrocytoma (PXA), a rare cerebral tumor of young adults with a slow growth and a good prognosis, resembles to the lytic phase of progressive multifocal leukoencephalopathy, a fatal neurodegenerative disease caused by JC polyomavirus (JCPyV).
Valeria Pietropaolo +2 more
exaly +4 more sources
JCPyV VP1 Mutations in Progressive Multifocal Leukoencephalopathy: Altering Tropism or Mediating Immune Evasion? [PDF]
Viruses, 2020 Polyomaviruses are ubiquitous human pathogens that cause lifelong, asymptomatic infections in healthy individuals. Although these viruses are restrained by an intact immune system, immunocompromised individuals are at risk for developing severe diseases driven by resurgent viral replication.
Matthew Lauver +2 more
exaly +4 more sources
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Infection by human polyomaviruses
AbstractBackground and ObjectivesA spectrum of blood‐borne infectious agents may be transmitted through transfusion of blood components from asymptomatic donors. Despite the persistence of polyomaviruses in blood cells, no studies have been conducted in Argentina to assess the risk of transfusion infection.Materials and MethodsWe investigated BKPyV and
María C. Frutos +5 more
openaire +3 more sources
Polyomavirus JC (JCPyV) reactivation and development of progressive multifocal leukoencephalopathy is a health concern in multiple sclerosis patients under natalizumab therapy. Here, the JCPyV microRNA-J1-3p and microRNA-J1-5p expressions and genomic variability were investigated in blood and urine samples of multiple sclerosis patients before and ...
, Simone Giannecchini, Massacesi Luca
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Adipocyte Plasma Membrane Protein (APMAP) promotes JC Virus (JCPyV) infection in human glial cells
Virology, 2020 The demyelinating disease progressive multifocal leukoencephalopathy (PML) is caused by the human polyomavirus, JCPyV, under conditions of prolonged immunosuppression. Initial infection is asymptomatic, and the virus establishes lifelong persistence in the host.
Walter Atwood +2 more
exaly +3 more sources
JCPyV T-Antigen Activation of the Anti-Apoptotic Survivin Promoter—Its Role in the Development of Progressive Multifocal Leukoencephalopathy [PDF]
Viruses, 2020 Progressive Multifocal Leukoencephalopathy (PML) is a fatal demyelinating disease of the CNS, resulting from the lytic infection of oligodendrocytes by the human neurotropic polyomavirus JC (JCPyV), typically associated with severe immunocompromised states and, in recent years, with the use of immunotherapies.
Sérgio Pina Oviedo +2 more
exaly +4 more sources
Detection of human JCPyV and BKPyV in diffuse large B-cell lymphoma of the GI tract
European Journal of Clinical Microbiology & Infectious Diseases, 2013Previous studies have demonstrated that infection with human polyomavirus, such as JCPyV and BKPyV, might be associated with various human tumors. However, an association between human JCPyV and BKPyV infection and diffuse large B-cell lymphoma (DLBCL) has not been reported.
C E, Tseng +7 more
openaire +2 more sources