Results 151 to 160 of about 1,462 (171)

Detection of human neurotropic JCPyV DNA sequence in pediatric anaplastic xanthoastrocytoma [PDF]

Journal of NeuroVirology, 2023
AbstractDue to its peculiar histopathological findings, pleomorphic xanthoastrocytoma (PXA), a rare cerebral tumor of young adults with a slow growth and a good prognosis, resembles to the lytic phase of progressive multifocal leukoencephalopathy, a fatal neurodegenerative disease caused by JC polyomavirus (JCPyV).
Valeria Pietropaolo, Ugo Moens, Carla Prezioso   +2 more
exaly   +5 more sources

JCPyV T-Antigen Activation of the Anti-Apoptotic Survivin Promoter—Its Role in the Development of Progressive Multifocal Leukoencephalopathy [PDF]

Viruses, 2020
Progressive Multifocal Leukoencephalopathy (PML) is a fatal demyelinating disease of the CNS, resulting from the lytic infection of oligodendrocytes by the human neurotropic polyomavirus JC (JCPyV), typically associated with severe immunocompromised states and, in recent years, with the use of immunotherapies.
Sergio Pina-Oviedo, Luis Del Valle, Georgina Perez-Liz   +2 more
exaly   +5 more sources

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Infection by human polyomaviruses JCPyV and BKPyV in blood donors of Argentina

Vox Sanguinis, 2023
AbstractBackground and ObjectivesA spectrum of blood‐borne infectious agents may be transmitted through transfusion of blood components from asymptomatic donors. Despite the persistence of polyomaviruses in blood cells, no studies have been conducted in Argentina to assess the risk of transfusion infection.Materials and MethodsWe investigated BKPyV and
María C. Frutos, Sebastián Blanco, Nubia Yandar Barahona, Arnaldo Mangeaud, Luis Horacio Carrizo, Sandra Gallego   +5 more
openaire   +3 more sources

Cloning of the first human anti-JCPyV/VP1 neutralizing monoclonal antibody: Epitope definition and implications in risk stratification of patients under natalizumab therapy

Antiviral Research, 2014
International audienceJC virus (JCPyV) has gained novel clinical importance as cause of progressive multifocal leukoencephalopathy (PML), a rare demyelinating disease recently associated to immunomodulatory drugs, such as natalizumab used in multiple ...
Giuseppe A. Sautto, Petr Man, Nicola Clementi   +2 more
exaly   +3 more sources

Detection of JCPyV microRNA in blood and urine samples of multiple sclerosis patients under natalizumab therapy

Journal of NeuroVirology, 2015
Polyomavirus JC (JCPyV) reactivation and development of progressive multifocal leukoencephalopathy is a health concern in multiple sclerosis patients under natalizumab therapy. Here, the JCPyV microRNA-J1-3p and microRNA-J1-5p expressions and genomic variability were investigated in blood and urine samples of multiple sclerosis patients before and ...
Simone Giannecchini, Alberta Azzi
exaly   +4 more sources

Adipocyte Plasma Membrane Protein (APMAP) promotes JC Virus (JCPyV) infection in human glial cells

Virology, 2020
The demyelinating disease progressive multifocal leukoencephalopathy (PML) is caused by the human polyomavirus, JCPyV, under conditions of prolonged immunosuppression. Initial infection is asymptomatic, and the virus establishes lifelong persistence in the host.
Walter Atwood, Bethany A O'Hara, Sheila A Haley   +2 more
exaly   +3 more sources

Detection of human JCPyV and BKPyV in diffuse large B-cell lymphoma of the GI tract

European Journal of Clinical Microbiology & Infectious Diseases, 2013
Previous studies have demonstrated that infection with human polyomavirus, such as JCPyV and BKPyV, might be associated with various human tumors. However, an association between human JCPyV and BKPyV infection and diffuse large B-cell lymphoma (DLBCL) has not been reported.
C E, Tseng, C M, Yeh, C Y, Fang, J, Shay, P L, Chen, M C, Lin, D, Chang, M, Wang   +7 more
openaire   +2 more sources

The JCPYV DNA load inversely correlates with the viral microrna expression in blood and cerebrospinal fluid of patients at risk of PML

Journal of Clinical Virology, 2015
In light of their regulatory role, changes in the expression of Polyomavirus JC (JCPyV) microRNAs may be relevant for virus reactivation and the development of progressive multifocal leukoencephalopathy (PML).To investigate the presence of JCPyV-DNA and JCPyV microRNA expression in clinical specimens of patients at risk for PML.The JCPyV-DNA and ...
Rocca, Arianna, Martelli, Francesco, Delbue, Serena, Ferrante, Pasquale, BARTOLOZZI, DARIO, AZZI, ALBERTA, GIANNECCHINI, SIMONE   +6 more
openaire   +4 more sources

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Frontiers in Oncology, 2023
Faisal Klufah, Mousa Mobarki, Axel Zur Hausen   +2 more
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