Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]
, 1998 The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
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Journal of Immunology, 1996 B cell antigen receptor (BCR)-induced apoptosis in the WEHI-231 B lymphoma cell line can be prevented by engaging CD40. We have used this cell line to investigate the role of mitogen-activated protein (MAP) kinases in integrating BCR and CD40 signaling ...
Claire L. Sutherland +4 more
semanticscholar +1 more source
Virus Research, 2016 The mitogen-activated protein kinase (MAPK) pathways, which are central building blocks in the intracellular signaling network, are often manipulated by viruses of diverse families to favor their replication. Among the MAPK family, the extracellular signal-regulated kinase (ERK) pathway is known to be modulated during the infection with porcine ...
Lee, Changhee +2 more
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Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module [PDF]
, 2013 Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation.
Aberg +57 more
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Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. [PDF]
, 2007 c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (MMP) gene expression and joint destruction in inflammatory arthritis. It is phosphorylated by at least two upstream kinases, the mitogen-activated protein kinase kinases (MEK) MKK4 and MKK7,
Boyle, David L +3 more
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Journal of Pharmacological Sciences, 2003 Atherosclerosis preferentially occurs in areas of turbulent blood flow and low fluid shear stress, whereas laminar blood flow and high shear stress are atheroprotective.
Masanori Yoshizumi +4 more
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Activation of the cellular mitogen-activated protein kinase pathways ERK, P38 and JNK duringToxoplasma gondiiinvasion [PDF]
Parasite, 2003 Host cell invasion is essential for the pathogenicity of the obligate intracellular protozoan parasite Toxoplasma gondii. In the present study, we evaluated the ability of T. gondii tachyzoites to trigger phosphorylation of the different mitogen-activated protein kinases (MAPK) in human monocytic cells THP1.
Valère A. +5 more
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A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury [PDF]
, 2014 Background Many diseases and pathological conditions are characterized by transient or constitutive overproduction of reactive oxygen species (ROS).
Ashraf, Muhammad Imtiaz +17 more
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High mobility group box 1 induced human lung myofibroblasts differentiation and enhanced migration by activation of MMP-9. [PDF]
PLoS ONE, 2015 High mobility group box 1 (HMGB1) is a nuclear protein that involves the binding with DNA and influences chromatin regulation and transcription. HMGB1 is also a cytokine that can activate monocytes and neutrophils involved in inflammation. In this study,
Chen-Chen Lee +4 more
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Immunolocalization of dually phosphorylated MAPKs in dividing root meristem cells of Vicia faba, Pisum sativum, Lupinus luteus and Lycopersicon esculentum [PDF]
, 2015 Key message In plants, phosphorylated MAPKs display constitutive nuclear localization; however, not all studied plant species show co-localization of activated MAPKs to mitotic microtubules.
A Bessard +42 more
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