Results 31 to 40 of about 11,418,388 (249)

The Effect of Job Demands on Burnout Among Employees of PT PLN on Madura Island with Job Resources as an Intervening Variable

Indonesian Interdisciplinary Journal of Sharia Economics
This study addresses the significant challenge of employee burnout, exacerbated by excessive job demands in the post-pandemic era, particularly within essential public service sectors like energy.
Angger Yulia Putra, Endang Suswati, Sugeng Mulyono   +2 more
doaj   +1 more source

AN EXPERIMENTAL VALIDATION OF THE JOB DEMANDS-RESOURCES THEORY

, 2023
In this work, we tested basic propositions of the job demands-resources (JD-R) theory. The vignette technique was applied. A 2 × 2 experimental design was used, defined by the following between-partic-ipants factors: resources (high vs. low) and demands (
Capozza D., DE CARLO A., Falvo R., De Carlo Alessandro, Capozza Dora, Falvo Rossella   +5 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Job tenure: A shield against the health impairment process of job demands-resources theory

Ψυχολογία: το Περιοδικό της Ελληνικής Ψυχολογικής Εταιρείας
According to the health impairment process of job demands-resources (JD-R) theory, job demands deplete employees’ energy, leading to high exhaustion.
Despoina Xanthopoulou, Evangelia Demerouti, Ioannis Nikolaou , Maria Vakola   +3 more
doaj   +1 more source

Understanding the Contribution of HRM Bundles for Employee Outcomes Across the Life-Span

Frontiers in Psychology, 2019
Using the Job Demands-Resources model literature and the life-span theory as scholarly frameworks, we examined the effects of job demands and job resources as mediators in the relationship between bundles of used HRM practices and employee outcomes.
Klaske N. Veth, Klaske N. Veth, Hubert P. L. M. Korzilius, Beatrice I. J. M. Van der Heijden, Beatrice I. J. M. Van der Heijden, Beatrice I. J. M. Van der Heijden, Beatrice I. J. M. Van der Heijden, Beatrice I. J. M. Van der Heijden, Ben J. M. Emans, Annet H. De Lange, Annet H. De Lange   +10 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Service-oriented job crafting for employee well-being in hotel industry: a job demands-resources perspective

Cogent Business & Management
The hotel industry, recognizing the critical need to understand the dynamics between job demands, job resources, service-oriented job crafting and employee well-being, investigates this interplay utilizing the Job-Demands-Resources (JD-R) theory as its ...
Yustisia Kristiana, Rosdiana Sijabat, Niko Sudibjo, Innocentius Bernarto   +3 more
doaj   +1 more source

Not all job demands are equal: differentiating job hindrances and job challenges in the Job Demands-Resources model [PDF]

, 2010
This study aimed to integrate the differentiation between two types of job demands, as made in previous studies, in the Job-Demands Resources (JD-R) model.
De Witte, Hans, Vansteenkiste, Maarten, Van den Broeck, Anja, De Cuyper, Nele, Decuyper, Nele   +4 more
core   +1 more source