Results 121 to 130 of about 191 (144)
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In silico prediction of drug solubility in water-dioxane mixtures using the Jouyban-Acree model.
Die Pharmazie, 2007A numerical method based on the Jouyban-Acree model was presented for prediction of drug solubility in water-dioxane mixtures at various temperatures. The method requires drug solubility in monosolvent systems, i.e. two data points for each temperature of interest. The mean percentage deviation (MPD) of predicted solubilities was calculated to show the
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Journal of Drug Delivery Science and Technology, 2007
A quantitative-structure property relationship (QSPR) was proposed for modeling deviations of solubilities of drugs in water-dioxane mixtures at various temperatures from the predicted solubilities by the Jouyban-Acree model. The QSPR employed the normalized values of the hydration energy, energy of the highest occupied molecular orbital, total energy,
A. Jouyban +3 more
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A quantitative-structure property relationship (QSPR) was proposed for modeling deviations of solubilities of drugs in water-dioxane mixtures at various temperatures from the predicted solubilities by the Jouyban-Acree model. The QSPR employed the normalized values of the hydration energy, energy of the highest occupied molecular orbital, total energy,
A. Jouyban +3 more
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Prediction of drug solubility in water-propylene glycol mixtures using Jouyban-Acree model.
Die Pharmazie, 2007A trained version of the Jouyban-Acree model was presented to predict drug solubility in water-propylene glycol mixtures at various temperatures. The model is able to predict the solubility in various solubility units and requires the experimental solubility of a solute in mono-solvent systems.
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Journal of Solution Chemistry, 2013
The solubility of piroxicam (PIR) in several ethanol + water mixtures was determined at five temperatures from 293.15 to 313.15 K. The thermodynamic functions; Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data and the drug properties of fusion by using the van’t Hoff and Gibbs equations. The greatest
Reinaldo G. Sotomayor +4 more
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The solubility of piroxicam (PIR) in several ethanol + water mixtures was determined at five temperatures from 293.15 to 313.15 K. The thermodynamic functions; Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data and the drug properties of fusion by using the van’t Hoff and Gibbs equations. The greatest
Reinaldo G. Sotomayor +4 more
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Solubility Prediction of Anthracene in Non-Aqueous Solvent Mixtures Using Jouyban-Acree Model
Iranian Journal of Pharmaceutical Sciences, 2006A quanitative structure property relationship was proposed to calculate the binary interaction terms of the Jouyban-Acree model using solubility parameter, boiling point, vapour pressure and density of solvents. The applicability of the proposed method for reproducing solubility data of anthracene in binary solvents has been evaluated using 116 ...
Jouyban, Abolghasem +3 more
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Die Pharmazie, 2008
Deviations of the predicted solubilities using the Jouyban-Acree model from experimental data were correlated to the structural descritptors of the drugs computed by HyperChem® software. The proposed models are able to predict the solubility in water-cosolvent mixtures and reduced the mean percentage deviations (MPD) of predicted solubilities from 24%,
A, Jouyban +4 more
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Deviations of the predicted solubilities using the Jouyban-Acree model from experimental data were correlated to the structural descritptors of the drugs computed by HyperChem® software. The proposed models are able to predict the solubility in water-cosolvent mixtures and reduced the mean percentage deviations (MPD) of predicted solubilities from 24%,
A, Jouyban +4 more
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AIP Conference Proceedings, 2016
The density of imidazolium-based ionic liquid, 1-ethyl-3-methylimidazolium diethylphosphate with sulfolane were measured at atmospheric pressure. The experiments were performed at T= (293 – 343) K over the complete mole fractions. Physical and thermodynamic properties such as molar volumes, V0, and excess molar volumes, VE for this binary mixtures were
Noraini Abd Ghani +4 more
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The density of imidazolium-based ionic liquid, 1-ethyl-3-methylimidazolium diethylphosphate with sulfolane were measured at atmospheric pressure. The experiments were performed at T= (293 – 343) K over the complete mole fractions. Physical and thermodynamic properties such as molar volumes, V0, and excess molar volumes, VE for this binary mixtures were
Noraini Abd Ghani +4 more
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The Journal of Chemical Thermodynamics, 2019
Abstract In recent years, the number of insoluble drug candidates has increased, with almost 70% of new drug candidates showing poor solubility. Cosolvent was used in this work to improve the solubility of poorly soluble temozolomide. The solubility data of temozolomide in four mixed solvents including (ethyl acetate + methanol), (ethyl acetate ...
Rongrong Li +8 more
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Abstract In recent years, the number of insoluble drug candidates has increased, with almost 70% of new drug candidates showing poor solubility. Cosolvent was used in this work to improve the solubility of poorly soluble temozolomide. The solubility data of temozolomide in four mixed solvents including (ethyl acetate + methanol), (ethyl acetate ...
Rongrong Li +8 more
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Analytical Methods, 2010
An extension to the Jouyban-Acree model was proposed to calculate the retention factor of analytes in RPLC with hydro-organic solvent mixtures as mobile phase by using the Abraham solvent coefficients and Abraham solute parameters. The accuracy of the proposed method was checked by computing the mean percentage deviation as a criterion.
Abolghasem Jouyban +3 more
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An extension to the Jouyban-Acree model was proposed to calculate the retention factor of analytes in RPLC with hydro-organic solvent mixtures as mobile phase by using the Abraham solvent coefficients and Abraham solute parameters. The accuracy of the proposed method was checked by computing the mean percentage deviation as a criterion.
Abolghasem Jouyban +3 more
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