Results 121 to 130 of about 20,657 (229)
Scientific ReportsJQ1, a small cell-permeable molecule is known for its potent inhibitory action on bromodomain and extraterminal (BET) proteins. Although earlier studies have shown its inhibitory effect on male gametogenesis, limited information is available about its ...
Keerthana Karunakar Poojary +12 more
doaj +1 more source
Advanced Science, Volume 13, Issue 11, 23 February 2026.In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong +11 more
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2018 Background Glioblastoma (GBM) is the most common and most malignant primary brain cancer in adults. Despite multimodality treatment, the prognosis is still poor.
Wei Meng +8 more
doaj +1 more source
Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication
Advanced Science, Volume 13, Issue 8, 9 February 2026.EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu +12 more
wiley +1 more source
Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters.
, 2019 Many physiological processes exhibit circadian rhythms driven by cellular clocks composed of interlinked activating and repressing elements. To investigate temporal regulation in this molecular oscillator, we combined mouse genetic approaches and ...
Budak, H. +4 more
core +1 more source
Nano letters (Print), 2019 Remodeling tumor immune microenvironment (TIME) is an important strategy to lift the immunosuppression and achieve immune normalization. In this work, a mannosylated lactoferrin nanoparticulate system (Man-LF NPs) is developed for dual-targeting ...
Hairui Wang +8 more
semanticscholar +1 more source
Advanced Science, Volume 13, Issue 10, 18 February 2026.By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang +27 more
wiley +1 more source
BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells
Haematologica, 2018 Although inhibitors of bromodomain and extra terminal domain (BET) proteins show promising clinical activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET inhibition on healthy hematopoietic (stem)
Mark Wroblewski +20 more
doaj +1 more source
JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer
Oncotarget, 2016 Overexpression of c-Myc is associated with worse outcomes in endometrial cancer, indicating that c-Myc may be a promising target for endometrial cancer therapy. A novel small molecule, JQ1, has been shown to block BRD4 resulting in inhibition of c-Myc expression and tumor growth.
Qiu, Haifeng +9 more
openaire +3 more sources
Computing the Mertens and Meissel-Mertens constants for sums over arithmetic progressions
, 2009 We give explicit numerical values with 100 decimal digits for the Mertens constant involved in the asymptotic formula for $\sum\limits_{\substack{p\leq x p\equiv a \bmod{q}}}1/p$ and, as a by-product, for the Meissel-Mertens constant defined as $\sum_{p ...
Cohen H. +5 more
core +1 more source