Results 1 to 10 of about 6,466 (124)
A convenient research strategy for functional verification of epigenetic regulators during spermatogenesis [PDF]
Asian Journal of AndrologySpermatogenesis is a fundamental process that requires a tightly controlled epigenetic event in spermatogonial stem cells (SSCs). The mechanisms underlying the transition from SSCs to sperm are largely unknown.
Shan Li +11 more
doaj +2 more sources
Genome-wide identification and expression analysis of JmjC domain-containing family in Vitis vinifera L. [PDF]
BMC GenomicsBackground In eukaryotes, histone methylation is essential for controlling chromatin structure, gene transcription, and related chromatin processes. Jumonji C (JmjC) domain-containing demethylases (JMJs) regulate histone methylation levels.
Mengqi Wang +3 more
doaj +2 more sources
Biomolecules, 2021 Histone methylation tightly regulates chromatin accessibility, transcription, proliferation, and cell differentiation, and its perturbation contributes to oncogenic reprogramming of cells.
Hans Felix Staehle +2 more
doaj +1 more source
The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer
Frontiers in Immunology, 2022 Inflammation has emerged as a key player in regulating cancer initiation, progression, and therapeutics, acting as a double edged sword either facilitating cancer progression and therapeutic resistance or inducing anti-tumor immune responses ...
Jia Yang +4 more
doaj +1 more source
Frontiers in Plant Science, 2022 Vernalization is the promotion of flowering after prolonged exposure to cold. In Arabidopsis thaliana, vernalization induces epigenetic silencing of the floral repressor gene FLOWERING LOCUS C (FLC).
Takashi Maruoka +4 more
doaj +1 more source
Targeting epigenetic regulators to overcome drug resistance in cancers
Signal Transduction and Targeted Therapy, 2023 Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions independent of nucleotide sequence changes.
Nan Wang, Ting Ma, Bin Yu
doaj +1 more source
JMJD family proteins in cancer and inflammation
Signal Transduction and Targeted Therapy, 2022 The occurrence of cancer entails a series of genetic mutations that favor uncontrollable tumor growth. It is believed that various factors collectively contribute to cancer, and there is no one single explanation for tumorigenesis.
Wang Manni +4 more
doaj +1 more source
Biomolecules, 2021 Exposure to moderately high temperature enables plants to acquire thermotolerance to high temperatures that might otherwise be lethal. In Arabidopsis thaliana, histone H3 lysine 27 trimethylation (H3K27me3) at the heat shock protein 17.6C (HSP17.6C) and ...
Nobutoshi Yamaguchi, Toshiro Ito
doaj +1 more source
The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain [PDF]
, 2020 Chromatin remodelling and transcription factors play important roles in lineage commitment and development through control of gene expression. Activation of selected lineage-specific genes and repression of alternative lineage-affiliated genes results in
Biasutto, Antonio J +4 more
core +1 more source
Frontiers in Plant Science, 2020 Abscisic acid (ABA) interacts antagonistically with brassinosteroids (BRs) to control plant growth and development in response to stress. The response to environmental cues includes hormonal control via epigenetic regulation of gene expression.
Jinfeng Wu +11 more
doaj +1 more source